Three dimensional measurements of collagen structure in a vascular tissue subject to abnormal mechanical remodeling
| Project/Area Number |
23650261
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
WADA Shigeo 大阪大学, 大学院・基礎工学研究科, 教授 (70240546)
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| Co-Investigator(Kenkyū-buntansha) |
中村 匡徳 埼玉大学, 理工学研究科, 准教授 (20448046)
福島 修一郎 大阪大学, 基礎工学研究科, 助教 (40362644)
越山 顕一朗 大阪大学, 基礎工学研究科, 助教 (80467513)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | バイオメカニクス / 生体光計測 / SHG / 血管組織 / コラーゲン / リモデリング / 計算力学解析 / 血管 |
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| Research Abstract |
This study experimental showed that the optical measurements using second harmonic generation (SHG) enable to observe the three dimensional distribution and orientation of collagen fibers in a vascular tissue. It was speculated from pathological analysis of the tissue specimen and the computational hemodynamic analysis of cerebral aneurysms that the complex stress field applied to the vascular tissue involves the 3D collagen structure measured with the SHG.
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Report
(3 results)
Research Products
(35 results)
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[Presentation] Computational studies on the strain transmission from a biological tissue to a cell and cytoskeletons2011
Author(s)
Wada, S., Soga, M., Ujihara, Y., Nakamura, M., Koshiyama, K., Miyazaki, H.
Organizer
ASME 2011 Summer Bioengineering Conference
Place of Presentation
ペンシルベニア州ファーミントン，USA
Related Report
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