| Project/Area Number |
23650266
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University (2012-2013)
Kyushu University (2011) |
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Principal Investigator |
NIIDOME Takuro 熊本大学, 自然科学研究科, 教授 (20264210)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 医用・生体画像 / バイオイメージング / MRI / オーバーハウザー効果 / 腫瘍 / プロテアーゼ / オーバーハウザー効果MRI / 電子スピン共鳴 / デンドリマー / ニトロキシラジカル / ペプチド / オーバーハウザー効果ＭＲＩ / ＥＳＲ |
|---|
| Research Abstract |
Overhauser-enhanced MRI (OMRI) is a double resonance technique that uses the presence of paramagnetic agents such as nitroxyl radicals to enhance the signal intensity from nuclear spins by a process known as the Overhauser effect. In this study, dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the OMRI signal from the radicals. This system could be the basis of a functional tumor imaging technique by OMRI.
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