Measurement of platelet activation process on shear blood flows and modeling of thrombus formation process
| Project/Area Number |
23650268
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
TAMAGAWA Masaaki 九州工業大学, 大学院・生命体工学研究科, 教授 (80227264)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | バイオメカニクス / 医用流体機械 / 血栓 / せん断流れ / 可視化 / 血液流れ / 血小板活性化 / 医用流体機器 |
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| Research Abstract |
In this investigation, thrombus formation process is modeled as three step process, which are activation of platelet, transport of activated platelet and adhesion of platlet to the wall and polymerization. Especially, the dependency of shear rate on the platelet activation was focused in this project. From this project, it is concluded that
(1) By working averaged shear rate from 100 to 200 (1/s), thrombus can be found at the wall, and the higher the shear rate becomes, the more thrombus formation rate increases
(2) By observation of luminescence with aequorin for detecting platelet-activation, the amplitude of luminescence is too low level comparing with background (SIN ratio) even if changing optical settina up.
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Report
(3 results)
Research Products
(15 results)
