Biomechanics of restenosis formation with stent

• Project/Area Number: 23650270
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Keio University
• Principal Investigator: TANISHITA Kazuo 慶應義塾大学, 理工学部, 名誉教授 (10101776)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: バイオメカニクス / 再狭窄 / 動脈病変 / 血流 / 応力分布 / 血管内治療

Research Abstract

The causes of restenosis may include the destruction of vessel wall by applying the excessive load and intimal thickening induced by shear stress of blood flow. This study focused on the mechanical analysis to reveal the role of mechanical factors causing

Research Products

• [Journal Article] Load-dispersing Design with Twined-spring Geometry of a Distensible Intracranial Stent for Cerebral Sneurysms (2013)
  • Author(s): Y. Shobayashi, K. Tanishita
  • Journal Title: Journal of Biorheology Volume: vol. 26 Pages: 29-37
  • Peer Reviewed
• [Journal Article] Intra-aneurysmal hemodynamic alterations by a self-expandable intracranial stent and flow diversionStent (2012)
  • Author(s): Y. Shobayashi, K. Tanishita
  • Journal Title: J Neurointervent Surg Volume: vol. 0 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Intra-aneurysmal hemodynamic alterations by a self-expandable intracranial stent and flow diversion stent (2012)
  • Author(s): Shobayashi, Y
  • Journal Title: J NeruroIntervent Surg Volume: 0 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Load-dispersing Design with Twined-spring Geometry of a Distensible Intracranial Stent for Cerebral Sneurysms (2012)
  • Author(s): Shobayashi, Y., Tateshima, S. and Tanishita, K.,
  • Journal Title: Journal of Biorheology (to appear) Volume: 26
  • Peer Reviewed
• [Presentation] ボクセル法を用いた脳動脈瘤内血行動態解析の妥当性検証 (2013)
  • Author(s): 筒井ひろみ、谷下一夫
  • Organizer: 第25回バイオエンジニアリング講演会
  • Place of Presentation: 筑波
• [Presentation] マクロからミクロに至る血流バイオメカニクスの意義 (2012)
  • Author(s): 谷下一夫
  • Organizer: 放射線医学総合研究所セミナー
  • Place of Presentation: 千葉
  • Year and Date: 2012-04-16
• [Presentation] Effect of wall shear stress on the arterial wall structure and enzyme expression in the inducedcerebral aneurysm with rabbits (2012)
  • Author(s): Tanishita, K.
  • Organizer: IUTAM Symposium
  • Place of Presentation: Russia, Izhevsk
• [Presentation] Effect of wall shear stress on the arterial wall structure and enzyme expression in the induced cerebral aneurysm with rabbits (2012)
  • Author(s): Tanishita, K
  • Organizer: IUTAM Symposium
  • Place of Presentation: Russia, Izhevsk
  • Invited
• [Presentation] ステント留置による脳動脈瘤内の血液流速変化 (2011)
  • Author(s): 竹中傑、谷下一夫
  • Organizer: 第20回日本コンピュータ外科学会大会
  • Place of Presentation: 横浜
• [Presentation] 高柔軟性脳血管ステントによる血管壁への応力負荷の軽減 (2011)
  • Author(s): 正林康宏,谷下一夫
  • Organizer: 第34回日本バイオレオロジー学会年会
  • Place of Presentation: 大阪
• [Presentation] ステント留置による血管壁への応答と再狭窄のメカニズム (2011)
  • Author(s): 奥田聡、正林康宏、立嶋智、谷下一夫
  • Organizer: 第34回日本バイオレオロジー学会年会
  • Place of Presentation: 大阪
• [Presentation] 高柔軟性脳血管ステントによる血管壁への応力負荷の軽減 (2011)
  • Author(s): 正林康宏、立嶋智、谷下一夫
  • Organizer: 日本バイオレオロジー学会
  • Place of Presentation: 大阪
• [Presentation] ステント留置によける血管壁への応答と再狭窄のメカニズム (2011)
  • Author(s): 奥田聡、正林康宏、立嶋智、谷下一夫
  • Organizer: 日本バイオレオロジー学会
  • Place of Presentation: 大阪
• [Presentation] マクロからミクロに至る血流バイオメカニクスの意義
  • Author(s): 谷下一夫
  • Organizer: 放射線医学総合研究所セミナー
  • Place of Presentation: 千葉県
  • Invited
• [Book] 生物流体力学 (2012)
  • Author(s): 谷下一夫
  • Publisher: 朝倉書店