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Development of visualization of soft tissue morphology and protein concentration by X-ray phase-contrast computed tomography.

Research Project

Project/Area Number 23650277
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionKawasaki Medical School

Principal Investigator

MOHRI Satoshi  川崎医科大学, 医学部, 教授 (00294413)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Ken  川崎医科大学, 医学部, 講師 (80341080)
UJIHARA Yoshihiro  川崎医科大学, 医学部, 助教 (80610021)
Co-Investigator(Renkei-kenkyūsha) UESUGI Kentaro  (財)高輝度光科学研究センター, 研究員 (80344399)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords位相差 CT / X 線 / タンパク濃度 / X線位相差CT / 濃度勾配 / 水晶体 / 心臓 / 可視化 / 国際情報交流(英国)
Research Abstract

Clinical X-ray computed tomography (CT) is based on the absorption of X-rays as they pass through the different parts of a patient's body. In this study, we developed phase-contrast X-ray CT that enables to visualize the fine texture of soft tissues that include similar X-ray absorbance materials. Moreover, we could firstly evaluate the concentration gradient of lens protein that enables to correct for spherical aberration. This method may provide new information about vital function.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Optical properties of in situ eye lenses measured with X-ray Talbot interferometry: a novel measure of growth processes.2011

    • Author(s)
      Hoshino M, Uesugi K, Yagi N, Mohri S, Regini J, Pierscionek B
    • Journal Title

      PLoS One

      Volume: 6(9)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical properties of in situ eye lenses measured with X-ray Talbot interferometry: a novel measure of growth processes.2011

    • Author(s)
      Hoshino M, Uesugi K, Yagi N, Mohri S, Regini J, Pierscionek B.
    • Journal Title

      PLoS One

      Volume: 6(9)

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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