Development of visualization of soft tissue morphology and protein concentration by X-ray phase-contrast computed tomography.
| Project/Area Number |
23650277
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MOHRI Satoshi 川崎医科大学, 医学部, 教授 (00294413)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Ken 川崎医科大学, 医学部, 講師 (80341080)
UJIHARA Yoshihiro 川崎医科大学, 医学部, 助教 (80610021)
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| Co-Investigator(Renkei-kenkyūsha) |
UESUGI Kentaro (財)高輝度光科学研究センター, 研究員 (80344399)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 位相差 CT / X 線 / タンパク濃度 / X線位相差CT / 濃度勾配 / 水晶体 / 心臓 / 可視化 / 国際情報交流（英国） |
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| Research Abstract |
Clinical X-ray computed tomography (CT) is based on the absorption of X-rays as they pass through the different parts of a patient's body. In this study, we developed phase-contrast X-ray CT that enables to visualize the fine texture of soft tissues that include similar X-ray absorbance materials. Moreover, we could firstly evaluate the concentration gradient of lens protein that enables to correct for spherical aberration. This method may provide new information about vital function.
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Report
(3 results)
Research Products
(2 results)
