Development of drug carrier for bone regeneration

• Project/Area Number: 23650282
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: ANADA Takahisa 東北大学, 大学院・歯学研究科, 准教授 (30398466)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Osamu 東北大学, 大学院・歯学研究科, 教授 (60374948)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 再生医工学材料 / 骨再生 / ドラッグデリバリー

Research Abstract

Novel calcium phosphate-binding lipids were synthesized. The polymer modified lipids were incorporated efficiently into liposomes. We found that the calcium phosphate binding and drug encapsulation efficiencies of the polymer modified liposomes were higher than those of the unmodified liposomes.

Research Products

• [Journal Article] Labile Zn ions on octacalcium phosphate-derived Zn-containing hydroxyapatite (2013)
  • Author(s): Y Honda, T Anada, S Morimoto, O Suzuki
  • Journal Title: Appl Sur Sci Volume: 273 Pages: 343-348
  • URL: http://dx.doi.org/10.1016/j.apsusc.2013.02.040
  • Peer Reviewed
• [Journal Article] Comparative study on in vitro biocompatibility of synthetic octacalcium phosphate and calcium phosphate ceramics used clinically (2012)
  • Author(s): S Morimoto, T Anada, Y Honda, O Suzuki
  • Journal Title: Biomed Mater Volume: 7 Issue: 4 Pages: 45020-45020
  • DOI: 10.1088/1748-6041/7/4/045020
  • Peer Reviewed
• [Journal Article] Structural, morphological and surface characteristics of two types of octacalcium phosphate-derived fluoride-containing apatitic calcium phosphates (2012)
  • Author(s): Yukari Shiwaku, Takahisa Anada, Hajime Yamazaki, Yoshitomo Honda, Shinji Morimoto, Keiichi Sasaki, Osamu Suzuki
  • Journal Title: Acta Biomaterialia Volume: 8 Issue: 12 Pages: 4417-4425
  • DOI: 10.1016/j.actbio.2012.07.041
  • Peer Reviewed
• [Journal Article] he effect of an octacalcium phosphate co-precipitated gelatin composite on the repair of critical-sized rat calvarial defects. (2012)
  • Author(s): Handa T, Anada T, Honda Y, Yamazaki H, Kobayashi K, Kanda N, Kamakura S, Echigo S, and Suzuki O.
  • Journal Title: Acta Biomater Volume: 8 Pages: 1190-1120
  • Peer Reviewed
• [Journal Article] Granule size-dependent bone regenerative capacity of octacalcium phosphate in collagen matrix. (2012)
  • Author(s): Tanuma Y, Anada T, Honda Y, Kawai T, Kamakura S, Echigo S, Suzuki O.
  • Journal Title: Tissue Eng Part A Volume: 18 Pages: 546-57
  • Peer Reviewed
• [Journal Article] The effect of synthetic octacalcium phosphate in a collagen scaffold on the osteogenicity of MSCs. (2011)
  • Author(s): Kawai T, Anada T, Masuda T, Honda Y, Sakai Y, Kato Y, Kamakura S, Echigo S, Suzuki O.
  • Journal Title: Eur Cell Mater Volume: 22 Pages: 124-36
  • Peer Reviewed
• [Presentation] リン酸オクタカルシウム/ゼラチン複合体のキャラクタリゼーションと細胞親和性 (2011)
  • Author(s): 穴田貴久、半田拓人、山崎元、本田義知、神田直典、越後成志、鈴木治
  • Organizer: 第58回日本歯科理工学会学術講演会
  • Place of Presentation: 郡山市
• [Presentation] Functional evaluation of bisphosphonate-lipid conjugates with polyethylene glycol linker. (2011)
  • Author(s): Anada T., Takeda T., Sakurai K., Suzuki O.
  • Organizer: The 3rd International Symposium on Surface and Interface of Biomaterials
  • Place of Presentation: 札幌市
• [Remarks]
  • URL: http://www.cfe.dent.tohoku.ac.jp/
• [Remarks] 東北大学大学院歯学研究科顎口腔機能創建学分野
  • URL: http://www.cfe.dent.tohoku.ac.jp/