Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
In this research, we attempted to improve cell specificity of gene delivery system with multiple securities. Thus, cationic polyethyleneimine and hydrophobic chain were introduced into our previously developed intracellular signal-responsive gene carrier. The carrier improved cancer cell specificity dramatically. Then, PEG chains were also incorporated into the carrier with pH-labile manner to stabilize the polyplex with DNA in blood circulation. Obtained carrier realized 1300 times activation in cancer cell against normal cell condition.
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