Super cell-specific gene delivery system using triple securities

• Project/Area Number: 23650290
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyushu University
• Principal Investigator: KATAYAMA Yoshiki 九州大学, 工学研究院, 教授 (70284528)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子送達 / DDS / 遺伝子治療 / がん / プロテインキナーゼ / ナノ粒子 / ナノメディスン

Research Abstract

In this research, we attempted to improve cell specificity of gene delivery system with multiple securities. Thus, cationic polyethyleneimine and hydrophobic chain were introduced into our previously developed intracellular signal-responsive gene carrier. The carrier improved cancer cell specificity dramatically. Then, PEG chains were also incorporated into the carrier with pH-labile manner to stabilize the polyplex with DNA in blood circulation. Obtained carrier realized 1300 times activation in cancer cell against normal cell condition.

Research Products

• [Journal Article] Gene carrier showing all-or-none response to cancer cell signaling (2012)
  • Author(s): R. Toita R, J-H. Kang, T . T omiyama, C-W . Kim, S. Shiosaki, T. Niidome, T. Mori, Y. Katayama
  • Journal Title: J. Am. Chem. Soc Volume: 134 Pages: 15410-15417
  • Peer Reviewed
• [Journal Article] Fluorometric detection of protein kinase Calpha activity based on phosphorylation-induced dissociation of a polyion complex (2012)
  • Author(s): R. Toita, T. Mori, Y. Naritomi, J-H Kang, S. Shiosaki, T. Niidome, Y. Katayama
  • Journal Title: Anal. Biochem Volume: 424 Pages: 130-136
  • Peer Reviewed
• [Journal Article] Improvement in the colloidal stability of protein kinase-responsive polyplexes by PEG modification (2012)
  • Author(s): A. Tsuchiya, Y . Naritomi, S. Kushio, J-H.Kang, M. Murata, M. Hashizume, T. Mori, T .Niidome, Y . Katayama
  • Journal Title: J. Biomed. Mater. Res. Part A Volume: 100 Pages: 1136-1141
  • Peer Reviewed
• [Journal Article] Creating a unique environment for selecting reactive enzymes with DNA: "Sticky" binding of oligocation-grafted polymers to DNA (2012)
  • Author(s): H. Tanaka, T. Mori, T. Niidome, Y. Katayama
  • Journal Title: Bioorg. Med. Chem Volume: 20 Pages: 1346-1353
  • Peer Reviewed
• [Journal Article] Correlation between phosphorylation ratios by MALDI-TOF MS analysis and radioactivities by radioactive assay (2012)
  • Author(s): A. Tsuchiya, D. Asai, J-H. Kang, T . Mori, T .Niidome, Y . Katayama
  • Journal Title: Anal. Biochem Volume: 421(2) Pages: 773-5
  • Peer Reviewed
• [Journal Article] Development of Human Hepatocellular Carcinoma Cell-Targeted Protein Cages (2012)
  • Author(s): R. Toita, M. Murata, S . Tabata, K. Abe, S.Narahara, J. Piao, J-H. Kang, M. Hashizume
  • Journal Title: Bioconjugate Chemistry Volume: 23 Pages: 1494-1501
  • Peer Reviewed
• [Journal Article] Gene Carrier Showing All-or-None Response to Cancer Cell Signaling (2012)
  • Author(s): Riki Toita, et al.
  • Journal Title: Journal of the American Chemical Society Volume: 134 Issue: 37 Pages: 15410-15417
  • DOI: 10.1021/ja305437n
  • Peer Reviewed
• [Journal Article] Fluorometric detection of protein kinase Calpha activity based on phosphorylation-induced dissociation of a polyion complex (2012)
  • Author(s): Riki Toita
  • Journal Title: Anal. Biochem. Volume: 424 Issue: 2 Pages: 130-136
  • DOI: 10.1016/j.ab.2012.01.036
  • Peer Reviewed
• [Journal Article] Correlation between phosphorylation ratios by MALDI-TOF MS analysis and radioactivities by radioactive assay (2012)
  • Author(s): Akira Tsuchiya, et al
  • Journal Title: Analytical Biochemistry Volume: 421 Issue: 2 Pages: 773-775
  • DOI: 10.1016/j.ab.2011.08.035
  • Peer Reviewed
• [Journal Article] Fluorescent nanoparticles consisting of lipopeptides and fluorescein-modified polyanions for monitoring of protein kinase activity (2011)
  • Author(s): H. Koga, R. Toita, T. Mori, T . Tomiyama, J-H.Kang, T . Niidome, Y . Katayama
  • Journal Title: Bioconjugate Chem Volume: 22 Pages: 1526-1534
  • Peer Reviewed
• [Journal Article] Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2) (2011)
  • Author(s): J-H. Kang, D. Asai, A. Tsuchiya, T. Mori, T. Niidome, Y. Katayama
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Effect of the introduction of condroitin sulfate into polymer-peptide conjugate responding to intracellular signals (2011)
  • Author(s): T. Tomiyama, R. Toita, J-H. Kang, H. Koga, S. Shiosaki, T. Mori, T . Niidome, Y . Katayama
  • Journal Title: Nanoscale Res. Lett Volume: 6 Pages: 532-532
  • Peer Reviewed
• [Journal Article] A hydrophilic polymer grafted with a histone tail peptide represents an artificial gene regulator activated by a histone acetyltransferase (2011)
  • Author(s): S. Shiosaki, M. Kuramoto, R. Toita, T. Mori, T. Niidome, Y. Katayama
  • Journal Title: Bioorg. Med. Chem Volume: 19 Pages: 4101-41405
  • Peer Reviewed
• [Journal Article] Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation (2011)
  • Author(s): A. Tsuchiya, J-H. Kang, D. Asai, T . Mori, T .Niidome, Y . Katayama
  • Journal Title: J. Controlled Release Volume: 155 Pages: 40-46
  • Peer Reviewed
• [Journal Article] A simple set-and-mix assay for screening of protein kinase inhibitors in cell lysates (2011)
  • Author(s): Asami, Y., Oishi, J., Kitazaki, H., Kamimoto, J., Kang, J.-H., Niidome, T., Mori, T., Katayama, Y.
  • Journal Title: Analytical Biochemistry Volume: 418 Issue: 1 Pages: 44-49
  • DOI: 10.1016/j.ab.2011.06.041
  • Peer Reviewed
• [Journal Article] Transgene regulation system responding to Rho associated coiled-coil kinase (ROCK) activation (2011)
  • Author(s): Akira Tsuchiya, et al
  • Journal Title: Journal of Controlled Release Volume: 155 Issue: 1 Pages: 40-46
  • DOI: 10.1016/j.jconrel.2011.05.002
  • Peer Reviewed
• [Journal Article] Fluorescent nanoparticles consisting of lipopeptides and fluorescein-modified polyanions for monitoring of protein kinase activity (2011)
  • Author(s): Koga, H., Toita, R., Mori, T., Tomiyama, T., Kang, J.-H., Niidome, T., Katayama, Y.
  • Journal Title: Bioconjugate Chemistry Volume: 22 Issue: 8 Pages: 1526-1534
  • DOI: 10.1021/bc200066w
  • Peer Reviewed
• [Journal Article] Peptide substrates for Rho-associated kinase 2 (Rho-kinase 2/ROCK2) (2011)
  • Author(s): Jeong-Hun Kang, et al
  • Journal Title: PLOS One Volume: 6 Issue: 7 Pages: e22699-e22699
  • DOI: 10.1371/journal.pone.0022699
  • Peer Reviewed
• [Journal Article] A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator (2011)
  • Author(s): Shiosaki, S., Kuramoto, M., Toita, R., Mori, T.,Niidome, T., Katayama, Y.
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 19 Issue: 13 Pages: 4101-4105
  • DOI: 10.1016/j.bmc.2011.05.011
  • Peer Reviewed
• [Journal Article] Controlled-release system of single-stranded DNA triggered by the photothermal effect of gold nanorods and its in vivo application (2011)
  • Author(s): Yamashita, S., Fukushima, H., Akiyama, Y., Niidome, Y., Mori, T., Katayama, Y., Niidome, T.
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 19 Issue: 7 Pages: 2130-2135
  • DOI: 10.1016/j.bmc.2011.02.042
  • Peer Reviewed
• [Journal Article] A solid-in-oil dispersion of gold nanorods can enhance transdermal protein delivery and skin vaccination (2011)
  • Author(s): Pissuwan, D., Nose, K., Kurihara, R., Kaneko, K., Tahara, Y., Kamiya, N., Goto, M., Katayama, Y., Niidome, T.
  • Journal Title: Small Volume: 7 Issue: 2 Pages: 215-220
  • DOI: 10.1002/smll.201001394
  • Peer Reviewed
• [Journal Article] Optimization of Peptide Density on Microarray Surface for Quantitative Phosphoproteomics (2011)
  • Author(s): Shimomura, T., Han, X., Hata, A., Niidome, T., Mori, T., Katayama, Y.
  • Journal Title: Analytical Sciences Volume: 27 Issue: 1 Pages: 13-17
  • DOI: 10.2116/analsci.27.13
  • NAID: 10027739412
  • ISSN: 0910-6340, 1348-2246
  • Peer Reviewed
• [Journal Article] Cancer-specific gene carriers responding to cancer microenvironment: acidosis and hyper-activated protein kinases
  • Author(s): S. Kushio, A. Tsuchiya, Y. Nakamura, T. Nobori, C. W. Kim, G. Zhao, D. Funamoto, E. K. Lee, K. Lee, T. Niidome, T. Mor, Y. Katayama
  • Journal Title: Biomed. Eng Volume: (in press)
  • Peer Reviewed
• [Journal Article] A protein kinase assay based on FRET between quantum dots and fluorescently labeled peptides
  • Author(s): S. Shiosaki, T. Nobori, T. Mori, C. W. KIm, T. Yamamoto, T. Niidome, Y. Katayama
  • Journal Title: Chem. Commun Volume: (in press)
  • Peer Reviewed
• [Journal Article] Serum protein kinase C-alpha as a diagnostic biomarker of cancers
  • Author(s): J-H. Kang, T . Mori, H. Kitazaki, T . Niidome, Y .Nakanishi, Y . Katayama
  • Journal Title: Cancer Biomarkers Volume: (in press)
  • Peer Reviewed
• [Journal Article] A polyion complex nanogel
  • Author(s): M. Takeo, T . Mori, T. Niidome, S. Sawada, K.Akiyoshi, Y . Katayama
  • Journal Title: J. Collod. Interf. Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells
  • Author(s): Y . Tahara, T . Kaneko, R. Toita, C. Yoshiyama, T. Kitaoka, T. Niidome, Y . Katayama, N. Kamiya, M. Goto
  • Journal Title: J. Controlled Release Volume: (in press)
  • Peer Reviewed
• [Presentation] ペプチド/高分子材料を用いる疾患特異的医療システムの創製 (2012)
  • Author(s): 片山佳樹
  • Organizer: 日本学術振興会・分子ナノテクノロジー第174 委員会 研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-12-14
• [Presentation] 創薬・診断・リスク評価のための細胞機能評価用バイオチップ (2012)
  • Author(s): 片山佳樹
  • Organizer: 福岡新テクノロジー創成シンポジウム
  • Place of Presentation: 福岡市
  • Year and Date: 2012-11-27
• [Presentation] Novel Cell Signal-responsive Polyplexes for Improved Colloidal Stability and Cell Specificity in Gene Delivery (2012)
  • Author(s): Yoshiki Katayama
  • Organizer: The 1st International Symposium on Application of Biomolecular Devices for Sustainable Functional Materials
  • Place of Presentation: 仙台市
  • Year and Date: 2012-10-19
• [Presentation] 細胞内シグナルに応答する分岐状ポリエチレンイミンによる遺伝子デリバリー (2012)
  • Author(s): 中村雄大、土谷享、森健、新留琢郎、片山佳樹
  • Organizer: 第49回化学関連支部合同九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2012-06-30
• [Presentation] 腫瘍特異的デリバリーを指向したナノキャリアの設計 (2012)
  • Author(s): 尚山堅士郎、渡部和人、千々岩信勝、森健、片山佳樹、新留琢郎
  • Organizer: 第49回化学関連支部合同九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2012-06-30
• [Presentation] MALDI-TOF-MS を用いる迅速なプロテインキナーゼ活性測定法の開発 (2012)
  • Author(s): 大坪裕紀、森健、新留琢郎、片山佳樹
  • Organizer: 第49回化学関連支部合同九州大会
  • Place of Presentation: 北九州市
  • Year and Date: 2012-06-30
• [Presentation] 創薬及び診断のためのキノーム解析用ペプチド・プロテインアレイ (2012)
  • Author(s): 片山佳樹
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡市
• [Presentation] Co-endocytosis and Co-receptor: Controling cell functions via modification of cell surface (2012)
  • Author(s): T. Mori, K. Tobinaga, M. Matsuda, M.Takeo, T. Niidome, Y. Katayama
  • Organizer: The 2nd International Symposium of Materials on Regenerative Medicine
  • Place of Presentation: Taiwan
• [Presentation] Intracellular signal-responding materials for new strategy of cell-specific gene delivery and in vivo imaging of disease functions (2012)
  • Author(s): Y. Katayama
  • Organizer: The 2nd International Symposium of Materials on Regenerative Medicine
  • Place of Presentation: Taiwan
• [Presentation] Intracellular signal-responding materials for new strategy of cell-specific gene delivery and in vivo imaging of disease functions (2012)
  • Author(s): Y. Katayama
  • Organizer: The 1st International Symposium on Polymer Ecomaterials
  • Place of Presentation: Changchun
• [Presentation] 金ナノロッドからの核酸のコントロールドリリースシステム (2012)
  • Author(s): 新留琢郎、福島寛満、山下秀治、森健、片山佳樹
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] 標的細胞内シグナルを検知し細胞を識別する遺伝子キャリヤー (2012)
  • Author(s): 片山佳樹
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Enhanced stability of cancer signal-responsive nanocarrier to improve the specificity of gene therapy (2012)
  • Author(s): 金燦宇、森健、新留琢郎、片山佳樹
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] プロテインキナーゼ応答型ポリマーの分子修飾とポリマー/DNA 複合体の安定性 (2012)
  • Author(s): 土谷享、森健、新留琢郎、片山佳樹
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] 腫瘍の低 pH 及び細胞内シグナル異常に応答する二重ターゲティング遺伝子キャリアの開発 (2012)
  • Author(s): 串尾聡之、土谷享、森健、新留琢郎、片山佳樹
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Disease signal-responsive siRNA: Silenced siRNA awakened by cellular protease (2012)
  • Author(s): 李恩卿、森健、新留琢郎、片山佳樹
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] 金ナノロッドのフォトサーマル効果による HSP70の誘導 (2012)
  • Author(s): 吉浦萌笑、森健、片山佳樹、新留琢郎
  • Organizer: 第28回日本 DDS 学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Protease imaging system by using polyion-complex and its application to prostate cancer (2012)
  • Author(s): S. Shisaki, M. Kuramoto, T. Mori, T.Niidome, Y. Katayama
  • Organizer: 39th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: Quebec, Canada
• [Presentation] 新規ペプチドのアフィニティー精製および細胞内プロテインキナーゼ活性の MALDI-TOF-MS によるディファレンシャル計測 (2012)
  • Author(s): 大坪裕紀、森健、新留琢郎、片山佳樹
  • Organizer: 第72回分析化学討論会
  • Place of Presentation: 鹿児島市
• [Presentation] ペプチド／高分子材料を用いる疾患特異的医療システムの創製 (2012)
  • Author(s): 片山佳樹
  • Organizer: 日本学術振興会・分子ナノテクノロジー第174委員会 研究会
  • Place of Presentation: 京都大学東京オフィス
  • Invited
• [Presentation] Novel Cell Signal-responsive Polyplexes for Improved Colloidal Stability and Cell Specificity in Gene Delivery (2012)
  • Author(s): Yohsiki Katayama
  • Organizer: The 1st International Symposium on Application of Biomolecular Devices for Sustainable Functional Materials
  • Place of Presentation: 東北大学
  • Invited
• [Presentation] 診断・創薬のための新しい細胞シグナルセンシング (2012)
  • Author(s): 片山佳樹
  • Organizer: 日本分析化学会第61年会
  • Place of Presentation: 金沢大学
  • Invited
• [Presentation] Cellular signal-responsive molecular system for disease cell-specific gene delivery and imaging. (2012)
  • Author(s): Yohsiki Katayama
  • Organizer: The 2nd International Symposium of Materials on Regenerative Medicine
  • Place of Presentation: Taipei Medical University
  • Invited
• [Presentation] Intracellular signal-responding materials for new strategy of cell-specific gene delivery and in vivo imaging of disease functions (2012)
  • Author(s): Yohsiki Katayama
  • Organizer: The 1st International Symposium on Polymer Ecomaterials
  • Place of Presentation: Changchun Institute of Applied Chemistry
  • Invited
• [Presentation] Protease imaging system by using polyion-complex and its application to prostate cancer (2012)
  • Author(s): Shujuro Shisaki, Masanori Kuramoto, Takeshi Mori, Takuro Niidome, Yoshiki Katayama
  • Organizer: 39th Annual Meeting & Exposition of the Controlled Release Society
  • Place of Presentation: The Centre des Congres de Quebec City
• [Presentation] 標的細胞内シグナルを検知し細胞を識別する遺伝子キャリヤー (2012)
  • Author(s): 片山佳樹
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
  • Invited
• [Presentation] Enhanced stability of cancer signal-responsive nanocarrier to improve the specificity of gene therapy (2012)
  • Author(s): 金燦宇、森健、新留琢郎、片山佳樹
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 腫瘍の低pH及び細胞内シグナル異常に応答する二重ターゲティング遺伝子キャリアの開発 (2012)
  • Author(s): 串尾聡之、土谷享、森健、新留琢郎、片山佳樹
  • Organizer: 第28回日本DDS学会学術集会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 細胞内シグナルを用いる新しい診断・治療・創薬のためのツール (2011)
  • Author(s): 片山佳樹
  • Organizer: 幹細胞治療研究フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2011-11-24
• [Presentation] 細胞内プロテインキナーゼプロファイリングのためのペプチドアレイ (2011)
  • Author(s): 片山佳樹
  • Organizer: Sysmex プロテインカンファレンス
  • Place of Presentation: 神戸市
  • Year and Date: 2011-10-12
• [Presentation] 高分子-ペプチド複合体により遺伝子の転写制御 (2011)
  • Author(s): 片山佳樹、塩崎秀二郎、佐藤祐子、森健、新留琢郎
  • Organizer: 高分子討論会
  • Place of Presentation: 岡山市
  • Year and Date: 2011-09-28
• [Presentation] ポリマー/ペプチドコンジュゲートを用いるがんイメージング剤 (2011)
  • Author(s): 片山佳樹、倉本政則、戸井田力、塩崎秀二郎、森健、新留琢郎
  • Organizer: 高分子討論会
  • Place of Presentation: 岡山市
  • Year and Date: 2011-09-28
• [Presentation] 生体分析への挑戦 (2011)
  • Author(s): 片山佳樹
  • Organizer: 日本分析化学会年会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-09-14
• [Presentation] Intracellular signal responsive gene regulation system for disease cell specific therapy and imaging (2011)
  • Author(s): Y. Katayama
  • Organizer: 17th Annual Meeting of Japan Society of Gene Therapy
  • Place of Presentation: 福岡市
  • Year and Date: 2011-07-15
• [Presentation] New gene regulation delivery system using peptide-pendant polyethyleneimine for cancer cell-specific therapy and imaging (2011)
  • Author(s): Y. Katayama, R. Toita, J-H. Kang, T. Mori, T. Niidome
  • Organizer: American Society of Gene & Cell Therapy 14th Annual Meeting
  • Place of Presentation: 米国
  • Year and Date: 2011-05-19
• [Presentation] 細胞内シグナルを用いる新しい診断・治療・創薬のためのツール (2011)
  • Author(s): 片山佳樹
  • Organizer: 幹細胞治療研究フォーラム(招待講演)
  • Place of Presentation: 東京大学医科学研究所
• [Presentation] 細胞シグナルに応答したsiRNAデリバリーシステムの開発 (2011)
  • Author(s): 川並寛幸、イウンキョン、李翠翠、戸井田力、森健、新留琢郎、片山佳樹
  • Organizer: 2011年日本化学会西日本大会
  • Place of Presentation: 徳島大学工学部
• [Presentation] 細胞内タンパク質デリバリーの高効率化を目指した新規ポリイオンコンプレックス型ナノゲルの創製 (2011)
  • Author(s): 竹尾将史、森健、新留琢郎、片山佳樹
  • Organizer: 第33回バイオマテリアル学会大会
  • Place of Presentation: 京都テルサ
• [Presentation] プロテインキナーゼCαに応答して送達遺伝子を放出するポリマー (2011)
  • Author(s): 田中洋行、森健、新留琢郎、片山佳樹
  • Organizer: 第33回バイオマテリアル学会大会
  • Place of Presentation: 京都テルサ
• [Presentation] 細胞内プロテインキナーゼプロファイリングのためのペプチドアレイ (2011)
  • Author(s): 片山佳樹
  • Organizer: Sysmexプロテインカンファレンス(招待講演)
  • Place of Presentation: Sysmex本社・神戸市
• [Presentation] 高分子－ペプチド複合体により遺伝子の転写制御 (2011)
  • Author(s): 片山佳樹、塩崎秀二郎、佐藤祐子、森健、新留琢郎
  • Organizer: 第60回高分子討論会(招待講演)
  • Place of Presentation: 岡山大学
• [Presentation] ポリマー／ペプチドコンジュゲートを用いるがんイメージング剤 (2011)
  • Author(s): 片山佳樹、倉本政則、戸井田力、塩崎秀二郎、森健、新留琢郎
  • Organizer: 第60回高分子討論会(招待講演)
  • Place of Presentation: 岡山大学
• [Presentation] 生体分析への挑戦 (2011)
  • Author(s): 片山佳樹
  • Organizer: 日本分析化学会第60年会(招待講演)
  • Place of Presentation: 名古屋大学東山キャンパス
• [Presentation] コレステロール修飾によるキナーゼ応答性ポリマー／DNA複合体の安定化 (2011)
  • Author(s): 土谷享、串尾聡之、森健、新留琢郎、片山佳樹
  • Organizer: 第11回アンチセンス・遺伝子・デリバリーシンポジウム
  • Place of Presentation: 大阪大学コンベンションセンター
• [Presentation] 細胞内シグナル応答型遺伝子キャリアの安定性向上に向けた検討 (2011)
  • Author(s): 土谷享、森健、新留琢郎、片山佳樹
  • Organizer: 第27回DDS学会学術集会
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] PEG切断能を有する細胞内シグナル応答型遺伝子キャリアの開発 (2011)
  • Author(s): 串尾聡之、土谷享、森健、新留琢郎、片山佳樹
  • Organizer: 第27回DDS学会学術集会
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] Intracellular signal responsive ・・・ (2011)
  • Author(s): Yoshiki Katayama
  • Organizer: 17th Annual Meeting of JSGT(招待講演)
  • Place of Presentation: 九州大学百年記念ホール
• [Presentation] Linear poly(ethyleneimine)-peptide ・・・ (2011)
  • Author(s): キムチャンウー、戸井田力、森健、新留琢郎、片山佳樹
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] New gene regulation delivery ・・・ (2011)
  • Author(s): Yoshiki Katayama, et al
  • Organizer: ASGCT 14th Annual Meeting
  • Place of Presentation: ワシントン州コンベンションセンター、アメリカ
• [Book] Nanotechnological strategies for tumor-targeting delivery of drugs or genes (2012)
  • Author(s): Riki Toita, Yoshiki Katayama, Jeong-Hun Kang
  • Publisher: Nova Science Publishers
• [Book] 細胞内シグナル応答型遺伝子キャリア(ドラッグデリバリーシステムの新展開) (2012)
  • Author(s): 片山佳樹
  • Publisher: シーエムシー出版
• [Book] アレイチップでのセンシング(バイオセンシング・バイオイメージングのニュートレンド) (2012)
  • Author(s): 片山佳樹
  • Publisher: 化学同人
• [Book] Protein Kinases(Technologies for the use of ・・・ (2012)
  • Author(s): Yoshiki Katayama
  • Total Pages: 19
  • Publisher: InTech
• [Book] Technologies for the use of protein kinases into medical applications(Protein Kinases) (2011)
  • Author(s): Yoshiki Katayama
• [Remarks]
  • URL: http://www.chem.kyushu-u.ac.jp/~katayama/
• [Patent(Industrial Property Rights)] 金ナノロッドを含有する S/O 製剤 (2012)
  • Inventor(s): 新留琢郎、新留康郎、神谷典穂、後藤雅宏、片山佳樹、ダークロンピスワン、野瀬圭介、栗原亮介
  • Industrial Property Rights Holder: 九州大学
  • Industrial Property Number: 2010-136286
  • Filing Date: 2012-06-15
• [Patent(Industrial Property Rights)] アドレッサブルポジショナルスキャニング法によるペプチド基質スクリーニング方法 (2011)
  • Inventor(s): 片山佳樹、秦彬斗、矢山由洋、森健、新留琢郎
  • Industrial Property Rights Holder: 九州大学
  • Acquisition Date: 2011-08-29
  • Overseas
• [Patent(Industrial Property Rights)] タンパク質キナーゼの新規基質ペプチド (2011)
  • Inventor(s): 片山佳樹、秦彬斗、矢山由洋、韓暁明、下村隆、森健、新留琢郎
  • Industrial Property Rights Holder: 九州大学
  • Acquisition Date: 2011
  • Overseas
• [Patent(Industrial Property Rights)] タンパク質キナーゼの新規基質ペプチド (2011)
  • Inventor(s): 片山佳樹、秦彬斗、矢山由洋、韓暁明、下村隆、森健、新留琢郎
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2011
  • Overseas
• [Patent(Industrial Property Rights)] アドレッサブルポジショナルスキャニング法によるペプチド基質スクリーニング方法 (2011)
  • Inventor(s): 片山佳樹、秦彬斗、矢山由洋、森健、新留琢郎
  • Industrial Property Rights Holder: 九州大学
  • Filing Date: 2011
  • Overseas