| Project/Area Number |
23650292
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
HARADA Atsushi 大阪府立大学, 工学研究科, 准教授 (50302774)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノカプセル / フェニルボロン酸 / グルコース / 自己組織化高分子 / 糖尿病治療 |
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| Research Abstract |
Monodisperse polymer vesicles were obtained from head-tail type polycations composed of polyamidoamine (PAMAM) dendron and poly(L-lysine) tail (PAMAM dendron-PLL) in the mixing solvent ofmethanol and water. The introduction of cross-linkages between PLL tails using cross-linker bearing glycidyl groups at both ends provided the stabilization of vesicular structure of PAMAM dendron-PLL vesicles. Also, 4-carboxy-phenylboronic acid were introduced to the remained Lys residues using condensation reagent. For thus obtained nanocapsules with and without phenylboronic acid moieties, the change in average diameter with pH was evaluated by dynamic light scattering measurement. The prepared nanocapsules could show the size change through the change of ionization state of phenylboronic acid moieties, and this expected that the nanocpasules could exhibit the size change synchronizing with the change in glucose concentration.
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