• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on visualization of defect of internal elastic lamina of arterial wall for diagnosis of very early-stage atherosclerosis

Research Project

Project/Area Number 23650298
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionTohoku University

Principal Investigator

KANAI Hiroshi  東北大学, 大学院・工学研究科, 教授 (10185895)

Co-Investigator(Kenkyū-buntansha) SAIJO Yoshifumi  東北大学, 大学院・医工学研究科, 教授 (00292277)
Co-Investigator(Renkei-kenkyūsha) HASEGAWA Hideyuki  東北大学, 大学院・医工学研究科, 准教授 (00344698)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords動脈硬化症 / 医用超音波工学 / 内弾性板欠損 / 位相差トラッキング法 / 表面粗さ推定 / 位相差トラッキング法 / 非侵襲計測
Research Abstract

It would be useful to measure the minute surface roughness of the carotid arterial wall to detect the endothelial damage in the early-stage of atherosclerosis. In conventional ultrasonography, the axial resolution of a B-mode image depends on the ultrasonic wavelength of 150 μm at 10 MHz. Therefore, the surface roughness caused by atherosclerosis in an early stage cannot be measured using a conventional B-mode image obtained by ultrasonography because the roughness is10-20 μm. We have realized accurate transcutaneous estimation of such a minute surface profile using the lateral motion of the carotid arterial wall, which is estimated by block matching of received ultrasonic signals. The proposed method was proved to be able to measure minute surface profile of about 10 μm by measuring a phantom, which had a saw tooth profile on its surface. Furthermore, the surface roughness of the carotid arterial walls of 10-50 μm were measured reproducibly for three healthy subjects (24-, 23-, and 23-year-old males).

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (51 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (29 results) Book (4 results) Remarks (1 results)

  • [Journal Article] High Frame Rate Echocardiography With Reduced Sidelobe Level2012

    • Author(s)
      Hideyuki Hasegawa and Hiroshi Kanai
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

      Volume: 59 Issue: 11 Pages: 2569-2575

    • DOI

      10.1109/tuffc.2012.2490

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accurate Estimation of Carotid Luminal Surface Roughness Using Ultrasonic Radio-Frequency Echo2012

    • Author(s)
      Kosuke Kitamura, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 51 Issue: 7S Pages: 07GF08-07GF08

    • DOI

      10.1143/jjap.51.07gf08

    • NAID

      210000140980

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Rate of Change in Thickness of Heart Wall by Measuring Time Variation2012

    • Author(s)
      Hiro Shida, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 51 Issue: 7S Pages: 07GF05-07GF05

    • DOI

      10.1143/jjap.51.07gf05

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Boundaries of Carotid Arterial Wall by Analyzing Ultrasonic RF Signals2012

    • Author(s)
      Nabilah Ibrahim, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 51 Issue: 7S Pages: 07GF07-07GF07

    • DOI

      10.1143/jjap.51.07gf07

    • NAID

      210000140979

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in Accuracy of Ultrasonic Measurement of Transient Change in Viscoelasticity of Radial Arterial Wall Due to Flow-Mediated Dilation by Adaptive Low-Pass Filtering2012

    • Author(s)
      Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 51 Issue: 7S Pages: 07GF14-07GF14

    • DOI

      10.1143/jjap.51.07gf14

    • NAID

      210000140986

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimization of Correlation Kernel Size for Accurate Estimation of Myocardial Contraction and Relaxation2012

    • Author(s)
      Yasunori Honjo, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Vol. 51, No.7 Issue: 7S Pages: 129-140

    • DOI

      10.1143/jjap.51.07gf06

    • NAID

      210000140978

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of Displacement and Strain in Biological Tissue Generated by Ultrasound Dual Acoustic Radiation Force2012

    • Author(s)
      Jun Yamaguchi, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 39 Issue: 4 Pages: 279-281

    • DOI

      10.1007/s10396-012-0372-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minute Mechanical-Excitation Wave-Front Propagation in Human Myocardial Tissue2011

    • Author(s)
      Hiroshi Kanai and Motonao Tanaka
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol. 50

    • NAID

      210000070876

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 二次元収縮弛緩特性計測を目指した心筋運動の高フレームレート計測2011

    • Author(s)
      本庄泰徳,長谷川英之,金井浩
    • Journal Title

      電子情報通信学会論文誌A

      Volume: vol.J94-A Pages: 826-835

    • NAID

      110008762178

    • URL

      http://search.ieice.org/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 二次元収縮弛緩特性計測を目指した心筋運動の高フレームレート計測2011

    • Author(s)
      本庄泰徳,長谷川英之,金井 浩
    • Journal Title

      電子情報通信学会論文誌A

      Volume: J94-A Pages: 826-835

    • NAID

      110008762178

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Automated Identification of the Heart Wall Throughout the Entire Cardiac Cycle Using Optimal Cardiac Phase for Extracted Features2011

    • Author(s)
      Hiroki Takahashi, Hideyuki Hasegawa, and Hiroshi kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Vol. 50, No.7 Issue: 7S Pages: 07HF16-07HF16

    • DOI

      10.1143/jjap.50.07hf16

    • NAID

      210000070965

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of the Elevational Distance between Image Planes by Analysis of Ultrasonic Echoes from Point Scatterers2011

    • Author(s)
      Atsuhiro Suzuki, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 50 Issue: 7S Pages: 07HF09-07HF09

    • DOI

      10.1143/jjap.50.07hf09

    • NAID

      210000070958

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Measurement of Transient Change in Viscoelasticity Due to Flow-Mediated Dilation Using Automated Detection of Arterial Wall Boundaries2011

    • Author(s)
      Kazuki Ikeshita, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 50 Issue: 7S Pages: 07HF08-07HF08

    • DOI

      10.1143/jjap.50.07hf08

    • NAID

      210000070957

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi Element Diverging Beam from a Linear Array Transducer for Transverse Cross Sectional Imaging of Carotid Artery : Simulations and Phantom Vessel Validation2011

    • Author(s)
      Akinlolu Ponnle, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Vol. 50, No.7 Issue: 7S Pages: 07HF05-07HF05

    • DOI

      10.1143/jjap.50.07hf05

    • NAID

      210000070954

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of Scatterer Diameter by Normalized Power Spectrum of High-Frequency Ultrasonic RF Echo for Assessment of Red Blood Cell Aggregation2011

    • Author(s)
      Taku Fukushima, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 50 Issue: 7S Pages: 07HF02-07HF02

    • DOI

      10.1143/jjap.50.07hf02

    • NAID

      210000070951

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-frame-rate echocardiography using diverging transmit beams and parallel receive beamforming2011

    • Author(s)
      Hideyuki Hasegawa and Hiroshi Kanai
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 38 Pages: 129-140

    • NAID

      130004496918

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Initial Phantom Validation of Minute Roughness Measurement Using Phase Tracking for Arterial Wall Diagnosis Non-Invasively In Vivo2011

    • Author(s)
      Magnus Cinthio, Hideyuki Hasegawa, and Hiroshi Kanai
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Contro

      Volume: 58 Issue: 4 Pages: 853-857

    • DOI

      10.1109/tuffc.2011.1879

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Measurement andAnalysis of Propagation of Myocardial Contraction Caused by Electrical Stimulation Using Myocardium of Rat2013

    • Author(s)
      Yuta Fujita, Hideaki Tagashira, Hideyuki Hasegawa, Kohji Fukunaga, and Hiroshi Kanai
    • Organizer
      7th International Symposium on Medical, Bio- and Nano-Electronics
    • Place of Presentation
      Sendai
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement and Analysis of Propagation of Myocardial Contraction Caused by Electrical Stimulation Using Myocardium of Rat2013

    • Author(s)
      Yuta Fujita, Hideaki Tagashira, Hideyuki Hasegawa, Kohji Fukunaga, and Hiroshi Kanai
    • Organizer
      7th International Symposium on Medical, Bio- and Nano-Electronics
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] Measurement of Shear Modulus of Phantom Mimicking Soft Tissue Using Acoustic Radiation Pressure Generated by Continuous Wave Ultrasound2013

    • Author(s)
      Kaori Tachi, Hideyuki Hasegawa, and Hiroshi Kanai
    • Organizer
      7th International Symposium on Medical, Bio- and Nano-Electronics
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ultrasound Elasticity Imaging of the Arterial Wall2012

    • Author(s)
      Hideyuki Hasegawa and Hiroshi Kanai
    • Organizer
      Euromech 534 Colloquium
    • Place of Presentation
      Saint Etienne, France
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] High Frame Rate Ultrasonography for Detailed Analysis of cardiovascular Dynamics2012

    • Author(s)
      Hideyuki Hasegawa, Hiroshi Kanai
    • Organizer
      18th International Symposium of Tohoku University Global COE ProgramGlobal Nano-Biomedical Engineering Education and Research Network Centre
    • Place of Presentation
      Sendai
    • Related Report
      2012 Final Research Report
  • [Presentation] Ultrasonic Actuation of Biological Tissues Using Dual Acoustic Radiation Force for Assessment of Elastic Properties2012

    • Author(s)
      Hideyuki Hasegawa, Jun Yamaguchi, and Hiroshi Kanai
    • Organizer
      Proceedings of International Symposium on Nolinear Acoustics
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Accurate Ultrasonic Measurement of Luminal Surface Roughness of Carotid Artery Using Arterial Longitudinal Motion2012

    • Author(s)
      Yoshifumi Nagai, Hideyuki Hasegawa, and Hiroshi Kanai
    • Organizer
      Euromech 534 Colloquium
    • Place of Presentation
      Saint Etienne, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] Automated Identification of the Heart Wall on Echocardiogram Throughout a Cardiac Cycle2012

    • Author(s)
      Hiroki Takahashi, Hideyuki Hasegawa, and Hiroshi Kanai
    • Organizer
      Medicinteknikdagarna
    • Place of Presentation
      Lund, Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] Suppression of Sidelobe in High Frame Rate Echocardiography Using Diverging Beams2012

    • Author(s)
      Hideyuki Hasegawa and Hiroshi Kanai
    • Organizer
      Medicinteknikdagarna
    • Place of Presentation
      Lund, Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increasing Bandwidth of Ultrasound RF Echoes Using Wiener Filter for Speckle Suppression2012

    • Author(s)
      影山 奨,長谷川英之,金井 浩
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Improvement of Automated Identification of the Heart wall by Reducing Stationary Clutter in Ultrasonic Echoes2012

    • Author(s)
      高橋広樹,長谷川英之,金井 浩
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detection of Arterial Wall Boundaries Using an Echo Model Composed of Multiple Ultrasonic Pulses2012

    • Author(s)
      Nabilah Ibrahim,長谷川英之,金井 浩
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Estimation of Radial Distribution of Ultrasound Scatterer Diameter for Assessment of Red Blood Cell Aggregation2012

    • Author(s)
      関 竜太郎,長谷川英之,金井 浩
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of a Method for Strain Imaging in Arterial Wall by Synthesizing Ultrasonic Echo Based on Strain Distribution Obtained by Finite Element Analysis2012

    • Author(s)
      白鳥和紀,長谷川英之,金井 浩
    • Organizer
      第33回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] High Frame Rate Ultrasonography for Detailed Analysis of Cardiovascular Dynamics2012

    • Author(s)
      Hideyuki Hasegawa, Hiroshi Kanai
    • Organizer
      18th International Symposium of Tohoku University Global COE Program Global Nano-Biomedical Engineering Education and Research Network Centre
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] Estimation of Scatterer Diameter Using Characteristic of Ultrasonic Backscattering for Quantitative Assessment of Red Blood Cell Aggregation2012

    • Author(s)
      Ryutaro Seki, Hideyuki Hasegawa, Hiroshi Kanai
    • Organizer
      6th International Symposium on Medical, Bio- and Nano-Electronics in Sendai
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] Accurate Boundary Detection of Posterior Carotid Arterial Wall Using the Template Matching Method for Measurement of Intima-Media Thickness2012

    • Author(s)
      Nabilah Ibrahim, Hideyuki Hasegawa, Hiroshi Kanai
    • Organizer
      6th International Symposium on Medical, Bio- and Nano-Electronics in Sendai
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] Suppression of Point Spread Function from Ultrasonic Echoes for Speckle Reduction in the Ultrasonography2012

    • Author(s)
      Sho Kageyama, Hideyuki Hasegawa, Hiroshi Kanai
    • Organizer
      6th International Symposium on Medical, Bio- and Nano-Electronics in Sendai
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] Accurate Ultrasonic Measurement of Surface Roughness of Carotid Arterial Wall Using Arterial Longitudinal Displacement2012

    • Author(s)
      Yoshifumi Nagai, Hideyuki Hasegawa, Hiroshi Kanai
    • Organizer
      6th International Symposium on Medical, Bio- and Nano-Electronics in Sendai
    • Place of Presentation
      Sendai
    • Related Report
      2011 Research-status Report
  • [Presentation] Expansion of Region of Accurate Estimation of Surface Roughness for Application to Carotid Luminal Surface2011

    • Author(s)
      北村浩典,長谷川英之,金井浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] Direct Measurement of Bekki-Nozaki(BN)Amplitude Holes in Nonlinear Waves on Cardiac Interventricular Septum(IVS)Wall2011

    • Author(s)
      金井浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] 局所心筋収縮弛緩特性計測のための2次元心臓壁運動の高フレームレート計測 High Frame Rate Measurement of Two-dimensional Heart Wall Motion for Assessment of Regional Myocardial Contraction and Relaxation2011

    • Author(s)
      本庄泰徳,長谷川英之,金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト動脈壁微小振動速度波形に含まれる進行波・反射波成分の可視化 Visualization of forward and reflected components in minute vibration velocity waveform of human arterial wall2011

    • Author(s)
      本江和恵,長谷川英之,金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] 厚み変化速度三次元分布計測による左心室内の心筋の収縮・弛緩の可視化 Visualizing Myocardial Contraction and Relaxation by Measuring 3D Distribution of Strain Rate in Heart Wall2011

    • Author(s)
      渡辺博文,長谷川英之,金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] 超音波後方散乱特性の時間変化計測による心筋厚み変化速度推定 Estimation of rate of change in thickness of myocardium by measuring time variation of ultrasonic integrated backscatter during a cardiac cycle2011

    • Author(s)
      志田 光,長谷川英之,金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] Detection of Boundaries of Carotid Arterial Wall by Analyzing Ultrasonic RF Signals2011

    • Author(s)
      Nabilah Ibrahim,Hideyuki Hasegawa,Hiroshi Kanai
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] 頸動脈壁内膜面への適用を目指した表面粗さ高精度推定における計測範囲の拡張 Expansion of Region of Accurate Estimation of Surface Roughness for Application to Carotid Luminal Surface2011

    • Author(s)
      北村浩典,長谷川英之,金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] 心室中隔壁上の非線形波動におけるBekki-Nozakiホールの直接測定 Direct Measurement of Bekki-Nozaki (BN) Amplitude Holes in Nonlinear Waves on Cardiac Interventricular Septum(IVS)Wall2011

    • Author(s)
      金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] 内皮機能評価のための橈骨動脈壁粘弾性特性変化の高精度計測 Accurate Measurement of Transient Change in Viscoelasticity of Radial Arterial Wall for Evaluation of Endothelial Function2011

    • Author(s)
      池下和樹,長谷川英之,金井 浩
    • Organizer
      The 32nd Symposium on Ultrasonic Electronics
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Book] American Institute of Physics2012

    • Author(s)
      Hideyuki Hasegawa, Jun Yamaguchi, Hiroshi Kanai
    • Publisher
      Nonlinear Acoustics
    • Related Report
      2012 Final Research Report
  • [Book] Imperial College Press2012

    • Author(s)
      Hideyuki Hasegawa, Hiroshi Kanai
    • Publisher
      Nano-Biomedical Engineering 2012
    • Related Report
      2012 Final Research Report
  • [Book] Nonlinear Acoustics2012

    • Author(s)
      Hideyuki Hasegawa, Jun Yamaguchi, Hiroshi Kanai
    • Publisher
      American Institute of Physics
    • Related Report
      2012 Annual Research Report
  • [Book] Nano-Biomedical Engineering 20122011

    • Author(s)
      Hideyuki Hasegawa, Hiroshi Kanai
    • Publisher
      Imperial College Press
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.ecei.tohoku.ac.jp/hkanai/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi