Development of Sono-cytometry by High Frequency Ultrasound

• Project/Area Number: 23650300
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: SAIJO Yoshifumi 東北大学, 大学院・医工学研究科, 教授 (00292277)
• Co-Investigator(Kenkyū-buntansha): KANAI Hiroshi 東北大学, 大学院・工学研究科, 教授 (10185895) ; HAYASE Toshiyuki 東北大学, 流体科学研究所, 教授 (30135313)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 高周波数超音波 / サイトメトリー / マイクロ流路 / ニューラルネットワーク

Research Abstract

Microfluidic circulation with suspension of micro-molecules was observed by high speed CCD camera. High frequency ultrasound of 120 MHz was emitted to the model and the spectrum of the reflected ultrasound was analyzed by neural network. The dimensions and structures of the micro-molecules were evaluated by the method. Application of the blood flow or lymph flow to the method in living subjects may realize in vivo “sono-cytometry" in the near future.

Research Products

• [Journal Article] High-resolution ultrasound imaging of human skin in vivo by using three-dimensional ultrasound microscopy (2012)
  • Author(s): Kumagai K, Koike H, Nagaoka R, Sakai S, Kobayashi K, Saijo Y
  • Journal Title: Ultrasound Med Biol Volume: Vol. 38, No. 10 Issue: 10 Pages: 1833-8
  • DOI: 10.1016/j.ultrasmedbio.2012.05.012
  • Peer Reviewed
• [Journal Article] Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders (2012)
  • Author(s): Hagiwara Y, Ando A, Onoda Y, Takemura T, Minowa T, Hanagata N, Tsuchiya M, Watanabe T, Chimoto E, Suda H, Takahashi N, Sugaya H, Saijo Y, Itoi E
  • Journal Title: Osteoarthritis Cartilage Volume: Vol. 20, No. 3 Issue: 3 Pages: 241-9
  • DOI: 10.1016/j.joca.2011.12.008
  • Peer Reviewed
• [Journal Article] Comparison of articular cartilage images assessed by high-frequency ultrasound microscope and scanning acoustic microscope (2012)
  • Author(s): Hagiwara Y, Saijo Y, Ando A, Onoda Y, Suda H, Chimoto E, Hatori K, Itoi E
  • Journal Title: Int Orthop Volume: Vol. 6, No. 1 Issue: 1 Pages: 185-90
  • DOI: 10.1007/s00264-011-1263-1
  • Peer Reviewed
• [Journal Article] Echogenicity in transrectal ultrasound is determined by sound speed of prostate tissue components (2012)
  • Author(s): Tanoue H, Hagiwara Y, Kobayashi K, Saijo Y
  • Journal Title: Conf Proc 34th IEEE Eng Med Biol Soc Volume: 1 Pages: 460-463
  • DOI: 10.1109/embc.2012.6345967
  • Peer Reviewed
• [Journal Article] Evaluation of vortex flow in left ventricle by echo-dynamography and phase contrast magnetic resonance angiography (2012)
  • Author(s): Kojima T, Kameyama T, Nakajima H, Khmyrova E, Kurokawa T, Saijo Y
  • Journal Title: Conf Proc 34th IEEE Eng Med Biol Soc Volume: 1 Pages: 2676-2679
  • DOI: 10.1109/embc.2012.6346515
  • Peer Reviewed
• [Journal Article] Imaging of sebaceous glands of human skin by three-dimensional ultrasound microscopy and its relation to elasticity (2011)
  • Author(s): Kumagai K, Koike H, Kudo Y, Nagaoka R, Kubo K, Kobayashi K, Saijo Y
  • Journal Title: Conf Proc 33rd IEEE Eng Med Biol Soc Volume: 1 Pages: 7199-7202
  • DOI: 10.1109/iembs.2011.6091819
  • Peer Reviewed
• [Journal Article] Ultrasonic tissue characterization of prostate biopsy tissues by ultrasound speed microscope (2011)
  • Author(s): Tanoue H, Hagiwara Y, Kobayashi K, Saijo Y
  • Journal Title: Conf Proc 33rd IEEE Eng Med Biol Soc Volume: 1 Pages: 8499-8402
  • DOI: 10.1109/iembs.2011.6092097
  • Peer Reviewed
• [Presentation] Feasibility of echo-dynamography in comparison of blood flow vectors obtained fromechocardiography and phase contrast magnetic resonance angiography (2013)
  • Author(s): Saijo Y, Kojima T, Khmyrova E, Omori A, Nakajima H, Kurokawa T, Tabuchi H, Kameyama T, Tanaka M.
  • Organizer: Asian Pacific Society of Cardiology2013 Congress (19th APCC or APSC2013)
  • Place of Presentation: Pattaya, Thailand
• [Presentation] Feasibility of echo-dynamography in comparison of blood flow vectors obtained from echocardiography and phase contrast magnetic resonance angiography (2013)
  • Author(s): Saijo Y, Kojima T, Khmyrova E, Omori A, Nakajima H, Kurokawa T, Tabuchi H, Kameyama T, Tanaka M
  • Organizer: Asian Pacific Society of Cardiology 2013 Congress
  • Place of Presentation: Pattaya, Thailand
• [Presentation] 超音波ドプラデータに基づく心臓内渦流の可視化 (2012)
  • Author(s): 小島貴則,中島博行,黒川貴史,大森愛子,西條芳文
  • Organizer: 第15回日本栓子検出と治療学会
  • Place of Presentation: 大阪
• [Presentation] 細動脈を模擬した生体ファントムの作製 (2012)
  • Author(s): 小松洋介,長岡亮,太田信,船本健一,早瀬敏幸,金井浩,西條芳文
  • Organizer: 第15回日本栓子検出と治療学会
  • Place of Presentation: 大阪
• [Presentation] Application of acoustic microscopy for prostate biopsy tissues. Key Note Lecture (2012)
  • Author(s): Saijo Y.
  • Organizer: 8th International Symposium on Ultrasonic Biomedical Microscanning
  • Place of Presentation: St- Paulin, Quebec, Canada
• [Presentation] 心エコーとMRIのハイブリッドイメージングによる左室内渦流の三次元評価 (2012)
  • Author(s): 西條芳文,小島貴則,亀山剛義,中島博行,田渕晴名,田中元直
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 金沢
• [Presentation] Recent development on biomedical acoustic microscopy (2012)
  • Author(s): Saijo Y.
  • Organizer: International Conference on Sensing, Imaging and Signal Processing
  • Place of Presentation: Santa Barbara, CA, USA.
• [Presentation] High resolution biomedical imaging - Multimodal ultrasound microscope and combination with optics (2012)
  • Author(s): Saijo Y.
  • Organizer: Invited Paper in The Acoustics2012 Hong Kong conference consisting a joint meeting of the 163rd meeting of the Acoustical Society of America (ASA), the 8th meeting of the Acoustical Society of China (ASC), the 11th Western Pacific Acoustics Conference (WESPAC) and the Hong Kong Institute of Acoustics (HKIOA) organized by the Hong Kong Institute of Acoustics
  • Place of Presentation: Hong Kong, China
• [Presentation] Evaluation of tissue components, biomechanics and blood flow by high frequency ultrasound (2012)
  • Author(s): Saijo Y.
  • Organizer: Invited Lecture in American Institute of Ultrasound in Medicine (AIUM)2012 Annual Convention
  • Place of Presentation: Phoenix, AZ, USA.
• [Presentation] High resolution biomedical imaging - Multimodal ultrasound microscope and combination with optics (2012)
  • Author(s): Saijo Y
  • Organizer: The Acoustics 2012 Hong Kong conference consisting a joint meeting of the 163rd meeting of the Acoustical Society of America (ASA)
  • Place of Presentation: Hong Kong, China
  • Invited
• [Presentation] Application of acoustic microscopy for prostate biopsy tissues (2012)
  • Author(s): Saijo Y
  • Organizer: 8th International Symposium on Ultrasonic Biomedical Microscanning
  • Place of Presentation: St-Paulin, Quebec, Canada
  • Invited
• [Presentation] Recent development on biomedical acoustic microscopy (2012)
  • Author(s): Saijo Y
  • Organizer: International Conference on Sensing, Imaging and Signal Processing
  • Place of Presentation: Santa Barbara, CA, USA
  • Invited
• [Presentation] Evaluation of tissue components, biomechanics and blood flow by high frequency ultrasound. (2012)
  • Author(s): Saijo Y
  • Organizer: 2012 AIUM Annual Convention(招待講演)
  • Place of Presentation: Phoenix, AZ, USA
• [Presentation] IVUS is still alive. (2011)
  • Author(s): Saijo Y
  • Organizer: 2011 IEEE International Ultrasonics Symposium(招待講演)
  • Place of Presentation: Orlando, MI, USA
• [Book] Color dependence of photoacoustic micro imaging. Andrzej Nowicki, Jerzy Litniewski, Tamara Kujawska eds (2012)
  • Author(s): Saijo Y, Koike H, Izumi T, Miida Y, Matsuura Y, Hozumi N
  • Publisher: Acoustical Imaging Vol 31, Springer
• [Book] Tribikram Kundu ed. Ultrasonic and Electromagnetic NDE for Structure and Material Characterization: Engineering and Biomedical Applications CRC Press (2012)
  • Author(s): Saijo Y.
  • Publisher: Clinical applications of ultrasonic nondestructive evaluation
• [Book] Technological Advancements in Biomedicine for Healthcare Applications, IGI Global (2012)
  • Author(s): Saijo Y.
  • Publisher: Biomedical application of multimodal ultrasound microscope.Jinlong Wu ed
• [Book] Acoustical Imaging (2012)
  • Author(s): Saijo Y, Koike H, Izumi T, Miida Y, Matsuura Y, Hozumi N
  • Publisher: Color dependence of photoacoustic micro imaging
• [Book] Ultrasonic and Electromagnetic NDE for Structure and Material Characterization: Engineering and Biomedical Applications (2012)
  • Author(s): Saijo Y
  • Publisher: Clinical applications of ultrasonic nondestructive evaluation
• [Book] Technological Advancements in Biomedicine for Healthcare Applications (2012)
  • Author(s): Saijo Y
  • Publisher: Biomedical application of multimodal ultrasound microscope
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/
• [Remarks]
  • URL: http://www.ecei.tohoku.ac.jp/imaging/