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Nanoplasmonic gene gun

Research Project

Project/Area Number 23650310
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionKeio University

Principal Investigator

TERAKAWA Mitsuhiro  慶應義塾大学, 理工学部, 講師 (60580090)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords低侵襲治療システム / レーザー医療 / レーザードラッグデリバリー / 増強局在近接場光
Research Abstract

We proposed and demonstrated nanosphere propulsion by using femtosecond-laser excited enhanced near-field. Velocity, angle, and diameter of propelled nanospheres were investigated and high spatial controllability of the propulsion was demonstrated based on the FDTD calculation and experiments. Little structural change was observed after the propulsion, indicating the potentiality to the drug propulsion with less damage effect to the embedded molecules.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (11 results)

  • [Journal Article] Gold nanosphere propulsion by using femtosecond laser-excited enhanced near field2014

    • Author(s)
      T. Shinohara, M. Terakawa
    • Journal Title

      Applied Physics A(オンライン先行公刊)

      Volume: 116 Issue: 3 Pages: 1025-1031

    • DOI

      10.1007/s00339-014-8328-0

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced near-field properties of a gap of TiO_2 nanosphere pairs for 3D photocatalytic optical trap2012

    • Author(s)
      T. Honda, M. Terakawa, M. Obara
    • Journal Title

      Proceedings of SPIE 8274

      Volume: 8274 Pages: 82740Z-82740Z

    • DOI

      10.1117/12.907207

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Spatial and size distribution of gold nanospheres propelled by femtosecond laser-excited enhanced near field2014

    • Author(s)
      篠原拓也
    • Organizer
      International Workshop on the Fabrication and Application of Microstructured Optical Devices
    • Place of Presentation
      横浜
    • Year and Date
      2014-02-28
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] The shape of nanospheres propelled by femtosecond laser-excited enhanced near field2014

    • Author(s)
      篠原拓也
    • Organizer
      SPIE Photonics West 2014
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2014-02-03
    • Related Report
      2013 Final Research Report
  • [Presentation] The shape of nanospheres propelled by femtosecond laser-excited enhanced near field2014

    • Author(s)
      T. Shinohara, M. Terakawa
    • Organizer
      SPIE Photonics West
    • Place of Presentation
      米国、サンフランシスコ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Calculational studies on controllability of nanosphere propulsion by using femtosecond laserexcited enhanced near field2013

    • Author(s)
      篠原拓也
    • Organizer
      Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR 2013)
    • Place of Presentation
      京都
    • Year and Date
      2013-07-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Calculational studies on controllability of nanosphere propulsion by using femtosecond laser-excited enhanced near field2013

    • Author(s)
      T. Shinohara, K. Hirano, G. Obara, M. Terakawa
    • Organizer
      2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR 2013)
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] フェムト秒レーザ励起局在増強近接場光生成プラズマによる微粒子推進2012

    • Author(s)
      篠原拓也
    • Organizer
      第73回応用物理学会学術講演会
    • Place of Presentation
      松山
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] レーザー励起局在増強近接場光による粒子推進を目指した光増強場解析2012

    • Author(s)
      篠原拓也
    • Organizer
      第12回レーザー学会東京支部研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhanced near-field properties of a gap of TiO_2 nanosphere pairs for 3D photocatalytic optical trap2012

    • Author(s)
      本多俊之
    • Organizer
      Photonics West 2012
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-01-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Toshiyuki Honda, Mitsuhiro Terakawa, Minoru Obara2012

    • Author(s)
      Enhanced near-field properties of a gap of TiO2 nanosphere pairs for 3D photocatalytic optical trap
    • Organizer
      SPIE Photonics West 2012
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 篠原拓也、小原豪、寺川光洋2012

    • Author(s)
      レーザー励起局在増強近接場光による粒子推進を目指した光増強場解析
    • Organizer
      第12回レーザー学会東京支部研究会
    • Place of Presentation
      東海大学高輪キャンパス, 東京
    • Related Report
      2011 Research-status Report
  • [Presentation] フェムト秒レーザ励起局在増強近接場光生成プラズマによる微粒子推進

    • Author(s)
      篠原拓也,小原豪,寺川光洋
    • Organizer
      第73回応用物理学会学術講演会
    • Place of Presentation
      愛媛県松山市
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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