A new molecular-based rehabilitation for neurodegenerative disease by in situ application of proteoglycan
| Project/Area Number |
23650319
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INOUE Katarzyna 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90302877)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Miki 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (70191533)
ZEREDO Jorge 東京医科歯科大学, 医歯(薬)学総合研究科, 非常勤講師 (10363459)
KUMEI Yasuhiro 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (30161714)
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| Co-Investigator(Renkei-kenkyūsha) |
YANAGISHITA Masaki 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (70132793)
HASEGAWA Katsuya 独立行政法人 宇宙航空研究開発機構, 宇宙科学研究所, 開発員 (30425780)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リハビリテーション医学 / プロテオグライカン |
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| Research Abstract |
Many neurodegenerative diseases are often caused due to abnormal formation of protein aggregates by transglutaminase 2 (TG2). Heparan sulfate proteoglycan (HSPG) has been also suggested to play critical role in many neurodegenerative diseases. Putative interaction of TG2 with HSPG has been suggested. The purpose of this study was to determine the role of HSPG species expressed by glial cells in cell-surface trafficking and biological activity of TG2 related to pathogenesis of neurodegeneration using an in vitro approach. Subcellular fractionation and immunocytochemical analyses showed that TG2-specific compartments were also specific for HSPGs suggesting possible interaction between those molecules. Understanding the bases of molecular interaction between TG2 and HSPGs and the precise role of HSPGs in regulation of biological activity of TG2 will help to identify the pathogenic mechanism of neurodegenerative diseases and to develop targeted rational therapy.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities2012
Author(s)
Hara-Yokoyama M., Kukimoto-Niino M., Terasawa K., Harumiya S., Podyma-Inoue K. A., Hino N., Sakamoto K., Itoh S., Hashii N., Hiruta Y., Kawasaki N., Mishima-Tsumagari C., Kaitsu Y., Matsumoto T., Wakiyama M., Shirouzu M., Kasama T., Ta
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Journal Title
Structure
Volume: 20
Issue: 9
Pages: 1585-1595
DOI
Related Report
Peer Reviewed
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