| Project/Area Number |
23650324
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kobe University |
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Principal Investigator |
FUJINO Hidemi 神戸大学, 大学院・保健学研究科, 教授 (20278998)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Akihiko 京都大学, 大学院・人間環境学研究科, 教授 (90184548)
MURAKAMI Shinichiro 姫路獨協大学, 医療保健学部, 准教授 (30454763)
KONDO Hiroyo 名古屋女子大学, 家政学部, 講師 (50333183)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 筋萎縮 / 運動 / 悪液質 / サイトカイン / カヘキシー / 炎症性サイトカイン / マイオカイン / リハビリテーション / 筋特異的リガーゼ |
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| Research Abstract |
The purpose of this study is to investigate the effects of exercise on muscle wasting caused by disuse and cancer. Cachexia resulted in the reduction of muscle cross-sectional area and metabolic enzyme, and the overexpression of TNF-α and atrogin-1/MAFbx. Exercise training attenuates muscle atrophy and the overexpression of TNF-α and atrogin-1/MAFbx. Thus, exercise training attenuates muscle wasting associated with some catabolic conditions. These results provide further evidence for the effects of exercise on muscle wasting. It was found that not only resistance exercise protocols, but also chronic endurance exercises could attenuate skeletal muscle wasting induced by disuse and cancer through down-regulation of TNF-α and indirect down-regulation of atrogin-1/MAFbx gene expression.
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