| Project/Area Number |
23650326
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Yamaguchi University |
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Principal Investigator |
INOUE Takao 山口大学, 大学院・医学系研究科, 学術研究員 (80513225)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Michiyasu 山口大学, 大学院・医学系研究科, 教授 (80196873)
FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
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| Co-Investigator(Renkei-kenkyūsha) |
NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
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| Research Collaborator |
HE Yeting 山口大学, 大学院・医学系研究科, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 局所脳冷却 / てんかん放電 / ローズベンガル / 脳虚血 / ペナンブラ / ニューロモデュレーション / ラット / ネコ / 光塞栓法 / 脳梗塞 / 脳波 / ペルチェ素子 / 急性期 |
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| Research Abstract |
We investigated whether FBC has a favorable effect on focal cerebral ischemia (FCI). Under general anesthesia, a small burr-hole was made and FCI was induced in the rat primary sensorimotor area (SI-MI) using photothrombosis. After that, FBC was performed. We report the novel finding that epileptiform discharges were suppressed in the ischemic border, the infarct area was reduced and neurobehaviour was preserved by FBC.
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