Neuroprotective effects of focal brain cooling on acute cerebrovascular disease

• Project/Area Number: 23650326
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Yamaguchi University
• Principal Investigator: INOUE Takao 山口大学, 大学院・医学系研究科, 学術研究員 (80513225)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Michiyasu 山口大学, 大学院・医学系研究科, 教授 (80196873) ; FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
• Co-Investigator(Renkei-kenkyūsha): NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
• Research Collaborator: HE Yeting 山口大学, 大学院・医学系研究科, 大学院生
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 局所脳冷却 / てんかん放電 / ローズベンガル / 脳虚血 / ペナンブラ / ニューロモデュレーション / ラット / ネコ / 光塞栓法 / 脳梗塞 / 脳波 / ペルチェ素子 / 急性期

Research Abstract

We investigated whether FBC has a favorable effect on focal cerebral ischemia (FCI). Under general anesthesia, a small burr-hole was made and FCI was induced in the rat primary sensorimotor area (SI-MI) using photothrombosis. After that, FBC was performed. We report the novel finding that epileptiform discharges were suppressed in the ischemic border, the infarct area was reduced and neurobehaviour was preserved by FBC.

Research Products

• [Journal Article] Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective. (2013)
  • Author(s): Yeting He
  • Journal Title: Brain Res Volume: 1497 Pages: 53-60
  • DOI: 10.1016/j.brainres.2012.11.041
  • Peer Reviewed
• [Journal Article] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions (2011)
  • Author(s): Fujii M, et al
  • Journal Title: Epilepsia Volume: 53 Issue: 3 Pages: 489-493
  • DOI: 10.1111/j.1528-1167.2011.03388.x
  • Peer Reviewed
• [Presentation] 局所脳冷却は脳皮質虚血により誘発されるてんかん性放電を抑制する (2013)
  • Author(s): 賀業霆、井上貴雄、丸田雄一、木田裕之、岡史朗、野村貞宏、藤井正美、大和田祐二、山川俊貴、山川烈、鈴木倫保
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山(岡山コンベンションセンター)
  • Year and Date: 2013-01-17
• [Presentation] Epidural Focal Brain Cooling suppresses Neocortical Seizures in Cats and Non-human Primates (2012)
  • Author(s): Takao Inoue, Masami Fujii, Hiroyuki Kida, Toshitaka Yamakawa, Yuichi Maruta, Tatsuji Tokiwa, Yeting He, Sadahiro Nomura, Yuji Owada, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 66th Annual Meeting of American Epilepsy Society (AES2012)
  • Place of Presentation: San Diego (San Diego Convention Center), USA
  • Year and Date: 2012-12-03
• [Presentation] Local brain hypothermia suppresses perifocal epileptiform discharges induced by focal cerebral ischemia in rats (2012)
  • Author(s): Yeting He, Masami Fujii, Takao Inoue, Sadahiro Nomura, Yuichi Yuichi Maruta, Yuji Owada, Hiroyuki Kida, Toshitaka Yamakawa, Tatsuji Tokiwa, and Michiyasu Suzuki
  • Organizer: 66th Annual Meeting of American Epilepsy Society (AES2012)
  • Place of Presentation: San Diego (San Diego Convention Center), USA
  • Year and Date: 2012-12-03
• [Presentation] Protective effects of focal brain cooling on photochemically-induced cerebral infarction (2012)
  • Author(s): 賀業霆、井上貴雄、丸田雄一、木田浩之、岡史朗、野村貞宏、藤井正美、大和田祐二、山川烈、鈴木倫保
  • Organizer: 第24回脳循環代謝学会総会
  • Place of Presentation: 広島(リーガロイヤルホテル広島)
  • Year and Date: 2012-11-09
• [Presentation] Focal brain cooling suppresses periodic epileptiform discharges and lessens brain injury after focal cerebral ischemia in rats (2012)
  • Author(s): 賀業霆,藤井正美,井上貴雄,野村貞宏,木田裕之,丸田雄一,国次一郎,山川烈,鈴木倫保
  • Organizer: 第46回日本てんかん学会(JES2012)
  • Place of Presentation: 東京(都市センターホテル)
  • Year and Date: 2012-10-11
• [Presentation] 霊長類を用いた痙攣誘発てんかんモデルに対する局所脳冷却と運動機能への抑制効果 (2012)
  • Author(s): 井上貴雄,藤井正美,木田裕之,山川俊貴,丸田雄一,賀業霆,常盤達司,野村貞宏,大和田祐二,山川烈,鈴木倫保
  • Organizer: 第46回日本てんかん学会(JES2012)
  • Place of Presentation: 東京(都市センターホテル)
  • Year and Date: 2012-10-11
• [Presentation] Challenges and Opportunities for development of a focal cooling device for intractable epilepsy (2012)
  • Author(s): Takao Inoue, Masami Fujii, Tatsuji Tokiwa, Yuichi Maruta, Hiroyuki Kida, Yeting He, Toshitaka Yamakawa, Hirochika Imoto, Sadahiro Nomura, Kenichi Hirano, Masanori Niiyama, Hiromi Yamazaki, Yuji Owada, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: Korean Epilepsy Congress (KEC2012)
  • Place of Presentation: Incheon (Songdo Convensia), Korea
  • Year and Date: 2012-06-08
• [Presentation] 霊長類を用いたてんかん発作に対する局所脳冷却療法の確立 (2012)
  • Author(s): 井上貴雄、藤井正美、常盤達司、山川俊貴、丸田雄一、木田裕之、賀業霆、野村貞宏、山川烈、鈴木倫保
  • Organizer: 第21回脳神経外科手術と機器学会
  • Place of Presentation: 大阪(ホテル阪急インターナショナル)
  • Year and Date: 2012-03-30
• [Presentation] 局所脳冷却によるてんかん発作抑制のための至適冷却温度についての検討 (2012)
  • Author(s): 井上貴雄、藤井正美,賀業霆,丸田雄一,野村貞宏,常磐達司,山川俊貴,山川烈,鈴木倫保
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京(東京ステーションコンファレンス)
  • Year and Date: 2012-01-20
• [Presentation] 機能神経外科の新たなアプローチ:Thermal neuromodulation (2012)
  • Author(s): 藤井正美、井上貴雄、賀業霆、丸田雄一、井本浩哉、田中信宏、奥高行、藤岡裕士、米田浩、小泉博靖、野村貞宏、鈴木倫保、山川烈
  • Organizer: 日本脳神経外科学会 第71回学術総会
  • Place of Presentation: 大阪(大阪国際会議場)
• [Presentation] Epidural Focal Brain Cooling suppresses Neocortical Seizures in Cats and Non-human Primates (2012)
  • Author(s): Takao Inoue
  • Organizer: 66th Annual Meeting of American Epilepsy Soceity (AES2012)
  • Place of Presentation: San Diego Convention Center, USA
• [Presentation] 霊長類を用いたてんかん発作に対する局所脳冷却療法の確立 (2012)
  • Author(s): 井上貴雄、藤井正美、常盤達司、山川俊貴、丸田雄一、木田裕之、賀業霆、野村貞宏、山川烈、鈴木倫保
  • Organizer: 第21回脳神経外科手術と機器学会
  • Place of Presentation: ホテル阪急インターナショナル（大阪）
• [Presentation] 霊長類を用いた薬物誘発てんかんモデルに対する局所脳冷却の効果 (2012)
  • Author(s): 井上貴雄，藤井正美，常磐達司，木田裕之，賀業霆，山川俊貴，井本浩哉，丸田雄一，野村貞宏，山川烈，鈴木倫保
  • Organizer: 第19回九州山口てんかん外科研究会
  • Place of Presentation: タカクラホテル福岡（福岡）
• [Presentation] 局所脳冷却によるてんかん発作抑制のための至適冷却温度についての検討 (2012)
  • Author(s): 井上貴雄、藤井正美，賀業霆，丸田雄一，野村貞宏，常磐達司，山川俊貴，山川烈，鈴木倫保
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京ステーションコンファレンス（東京）
• [Presentation] 局所脳冷却を用いた難治性てんかん治療装置の開発と臨床応用の実現に向けた医工連携 (2012)
  • Author(s): 藤井正美，井上貴雄，山川俊貴，常磐達司，野村貞宏，山崎博実，斎藤俊，大和田祐二，山川烈，鈴木倫保
  • Organizer: 第35回日本てんかん外科学会
  • Place of Presentation: 東京ステーションコンファレンス（東京）
• [Presentation] Effect of focal brain cooling on epileptic seizures and neurological functions (2011)
  • Author(s): Yeting He, Masami Fujii, Takao Inoue, Yuichi Maruta, Sadahiro Nomura, Tatsuji Tatsuji Tokiwa, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 5th Asian Epilepsy Surgery Congress (AESC 2011)
  • Place of Presentation: Hong Kong(Hong Kong Academy of Medicine)
  • Year and Date: 2011-11-10
• [Presentation] Development of a focal cerebral cooling system for the treatment of intractable epilepsy An experimental study in cats and non-human primates (2011)
  • Author(s): Takao Inoue, Masami Fujii, Yeting He, Yuichi Maruta, Hiroyuki Kida, Sadahiro Nomura, Tatsuji Tokiwao, Toshitaka Yamakawa, Kenichi Hirano, Masanori Niiyama, Hiromi Yamazaki, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: IEEE SMC
  • Place of Presentation: Anchorage (Hilton Anchorage), USA.
  • Year and Date: 2011-10-10
• [Presentation] Alternative treatment of intractable epilepsy with focal brain cooling A review of our past studies (2011)
  • Author(s): Masami Fujii, Takao Inoue, Yeting Yeting He, Yuichi Maruta, Hirochika Imoto, Hiroyasu Koizumi, Sadahiro Nomura, Tatsuji Tokiwa, Satoshi Ishizuka, Toshitaka Yamakawa, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: IEEE SMC
  • Place of Presentation: Anchorage (Hilton Anchorage), Alaska USA.
  • Year and Date: 2011-10-10
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling (2011)
  • Author(s): Masami Fujii, Takao Inoue, Yeting He, Hirochika Imoto, Nobuyuki Tanaka, T Oku, Yuichi Maruta, Hiroyasu Koizumi, Sadahiro Nomura, Yuji Owada, Takashi Saito, Toshitaka Yamakawa, Tatsuji Tatsuji Tokiwa, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome (Rome Marriott Park Hotel), Italy.
  • Year and Date: 2011-08-31
• [Presentation] Consortium of Advanced Epilepsy Treatment (CADET) "Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates" (2011)
  • Author(s): Takao Inoue, Yeting He, Masami Fujii, Hiroshi Fujioka, Tatsuji Tokiwa, Hiroyuki Hiroyuki Kida, Hirochika Imoto, Yuichi Maruta, Sadahiro Nomura, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome, Italy (Rome Marriott Park Hotel).
  • Year and Date: 2011-08-29
• [Presentation] Cooling of the epileptic focus suppresses seizures with minimal influence on neurological functions (2011)
  • Author(s): Masami Fujii, Takao Inoue, Sadahiro Nomura, Yuichi Yuichi Maruta, Yeting He, Tatsuji Tatsuji Tokiwa, Toshitaka Yamakawa, Yuji Owada, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 65th American Epilepsy Society Annual Meeting
  • Place of Presentation: Baltimore (Baltimore Convention Center), USA.
• [Presentation] 新治療法開発の手がかりを求めて大脳局所冷却療法 (2011)
  • Author(s): 藤井正美,井上貴雄,賀業霆,井本浩哉,丸田雄一,小泉博靖,野村貞宏,常盤達司,山川俊貴,山川烈,鈴木倫保
  • Organizer: 第45回日本てんかん学会
  • Place of Presentation: 新潟(新潟コンベンションセンター)
• [Presentation] Effect of focal brain cooling on epileptic seizures and neurological functions (2011)
  • Author(s): Yeting He, Masami Fujii, Takao Inoue, Yuichi Maruta, Sadahiro Nomura, Tatsuji Tokiwa, Takeshi Yamakawa, and Michiyasu Suzuki
  • Organizer: 5th Asian Epilepsy Surgery Congress (AESC 2011)
  • Place of Presentation: 香港（中国）
• [Presentation] Development of a focal cerebral cooling system for the treatment of intractable epilepsy -An experimental study in cats and non-human primates- (2011)
  • Author(s): T Inoue, M Fujii, Y He, Y Maruta, H Kida, S Nomura, T Tokiwa, T Yamakawa, K Hirano, M Niiyama, H Yamazaki, T Yamakawa, and M Suzuki
  • Organizer: IEEE SMC 2011(2011 IEEE International Conference on Systems, Man, and Cybernetics
  • Place of Presentation: アンカレッジ（米国）
• [Presentation] Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates (2011)
  • Author(s): Takao Inoue, Yeting He, Masami Fujii, Hiroshi Fujioka, Tatsuji Tokiwa, Hiroyuki Kida, Hirochika Imoto, Yuichi Maruta, Sadahiro Nomura, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 29th International Epilepsy Congres,
  • Place of Presentation: ローマ（イタリア）
• [Presentation] Cooling of the epileptic focus suppresses seizures with minimal influence on neurological functions (2011)
  • Author(s): Masami Fujii, Takao Inoue, Sadahiro Nomura, Yuichi Maruta, Yeting He, Tatsuji Tokiwa, Toshitaka Yamakawa, Yuji Owada, Takeshi Yamakawa, Michiyasu Suzuki
  • Organizer: 65th American Epilepsy Society Annual Meeting
  • Place of Presentation: ボルチモア（米国）
• [Presentation] Alternative treatment of intractable epilepsy with focal brain cooling -A review of our past studies- (2011)
  • Author(s): M Fujii, T Inoue, Y He, Y Maruta, H Imoto, H Koizumi, So Nomura, T Tokiwa, S Ishizuka, T Yamakawa, T Yamakawa, and M Suzuki
  • Organizer: IEEE SMC 2011(2011 IEEE International Conference on Systems, Man, and Cybernetics)
  • Place of Presentation: アンカレッジ（米国）
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling (2011)
  • Author(s): M Fujii, T Inoue, Y He, H Imoto, N Tanaka, T Oku, Y Maruta, H Koizumi, S Nomura, Y Owada, T Saito, T Yamakawa, T Tokiwa, T Yamakawa, and M Suzuki
  • Organizer: 29th International Epilepsy Congres
  • Place of Presentation: ローマ（イタリア）
• [Presentation] 新治療法開発の手がかりを求めて 大脳局所冷却療法 (2011)
  • Author(s): 藤井正美，井上貴雄，賀 業霆，井本 浩哉，丸田 雄一，小泉 博靖 野村 貞宏，常盤達司， 山川俊貴，山川烈，鈴木倫保
  • Organizer: 第45回日本てんかん学会(JES2011)
  • Place of Presentation: 朱鷺メッセ：新潟コンベンションセンター（新潟）
• [Presentation] Local brain hypothermia suppresses perifocal epileptiform discharges induced by focal cerebral ischemia in rats
  • Author(s): Yeting He
  • Organizer: 66th Annual Meeting of American Epilepsy Soceity (AES2012)
  • Place of Presentation: San Diego Convention Center, USA
• [Presentation] Challenges and Opportunities for development of a focal cooling device for intractable epilepsy
  • Author(s): Takao Inoue
  • Organizer: Korean Epilepsy Congress (KEC2012)
  • Place of Presentation: Songdo Convensia, Korea
  • Invited
• [Presentation] 局所脳冷却は脳皮質虚血により誘発されるてんかん性放電を抑制する
  • Author(s): 賀業霆
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山コンベンションセンター、岡山
• [Presentation] Protective effects of focal brain cooling on photochemically-induced cerebral infarction
  • Author(s): 賀業霆
  • Organizer: 第24回脳循環代謝学会総会
  • Place of Presentation: リーガロイヤルホテル広島、広島
• [Presentation] 機能神経外科の新たなアプローチ：Thermal neuromodulation
  • Author(s): 藤井正美
  • Organizer: 日本脳神経外科学会 第71回学術総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] Focal brain cooling suppresses periodic epileptifrom discharges and lessens brain injury after focal cerebral ischemia in rats
  • Author(s): 賀業霆
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 都市センターホテル、東京
• [Presentation] 霊長類を用いた痙攣誘発てんかんモデルに対する局所脳冷却と運動機能への抑制効果
  • Author(s): 井上貴雄
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 都市センターホテル、東京