| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
To quantify the efficacy of physiotherapy after the central nervous system injury, we evaluate gene expression changes between before and after rehabilitation/disuse by combining selective nuclear/cellular sorting of motor neurons and transcriptome analysis using next-generation sequencer. After the complete transection of spinal cord at mid-thoracic level, we collected motor neurons located in the level of lumbar intumescence with laser micro dissection at three months after injury, and performed gene expression analysis. This method will contribute to identify the possible biomarkers for establishment of efficient rehabilitation programs.
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