| Project/Area Number |
23650333
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KUBO Toshikazu 京都府立医科大学, 医学系研, 教授 (20178031)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Yuji 京都府立医科大学, 医学研究科, 講師 (50347449)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 変形性関節症 / heat shock protein 70 / 温熱療法 / 微弱電流刺激 / ユビキチン化タンパク / HSP70 / グルタミン |
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| Research Abstract |
We demonstrated mild electrical stimulation (MES) in combination with heat shock (HS) treatment induce heat shock protein 70 (HSP70) in chondrocytes and articular cartilage and enhances cartilage matrix metabolism.The increase of HSP70 protein in chondrocytes is also thought to be due to inhibition of the ubiquitin-proteasome system by MES, resulting in inhibition of HSP70 protein degradation and accumulation of HSP70 protein. MES in combination with HS can be a novel physical therapy for osteoarthritis by inducing HSP70 in articular cartilage.
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