Integrative Analysis of Structure and Extracellular Environment in Disuse Atrophic Skeletal Muscle
| Project/Area Number |
23650343
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Masamitsu 広島国際大学, 保健医療学部, 教授 (20198097)
OZAWA Junya 広島国際大学, 総合リハビリテーション学部, 准教授 (00435059)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 廃用性 / 筋萎縮 / 原子間力顕微鏡 / 筋細胞 / 骨格筋 / 心筋 / 細胞内カルシウム計測 / PassiveStiffness / 単離骨格筋細胞 / 収縮蛋白 / 廃用性萎縮 / Passive Stiffness / 受動的力学的特性 / 初代培養標本 / 免疫蛍光染色 |
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| Research Abstract |
Currently our country is facing a serious problem that the super-aging society. It is quite ideal that all elder people spend their life without being suffering from any physical and social discomfort. However, number of elder people have poor activity of daily life due to disuse syndrome, due to aging, paralysis with cerebral vascular diseases, chronic obstructive pulmonary disease, sarcopenia with fracture, congestive heart failure, and so on. Muscle atrophy is a condition that occurs not only in elder people, but also young healthy people in case of astronauts who is exposed to the microgravity environment, and cast immobilization due to fracture. Thus, it is important to reveal the mechanism of muscle atrophy and mechanical properties of atrophied muscle. In this study, we performed experiments of passive transvers stiffness of muscle cells with an atomic force microscope and x-ray diffraction of muscle tissue in synchrotron radiation facility.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Increased passive stiffness of cardiomyocytes in the transverse direction and residual actin and myosin cross-bridge formation in hypertrophied rat hearts induced by chronic β-adrenergic stimulation2013
Author(s)
Sumita Yoshikawa W, Nakamura K, Miura D, Shimizu J, Hashimoto K, Kataoka N, Toyota H, Okuyama H, Miyoshi T, Morita H, Fukushima Kusano K, Matsuo T, Takaki M, Kajiya F, Yagi N, Ohe T, Ito H. Circ J
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Journal Title
Epub
Volume: 77(3)
Pages: 741-8
NAID
Related Report
Peer Reviewed
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