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Effect of candidate gene polymorphisms on the tendon extensibility related to sport performances

Research Project

Project/Area Number 23650386
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionThe University of Tokyo

Principal Investigator

KUBO Keitaro  東京大学, 大学院・総合文化研究科, 准教授 (70323459)

Co-Investigator(Renkei-kenkyūsha) CHINO Kentaro  東京大学, 大学院・総合文化研究科, 助教 (30443245)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsトレーニング科学 / 腱 / ヒト生体 / 先天的 / 障害 / コラーゲン
Research Abstract

In the present study, we aimed to investigate the effects of injury-associated polymorphisms within these four genes on the mechanical properties of human tendon structures in vivo. One hundred Japanese males participated in this experiment. The mechanical properties of tendon structures in knee extensors and plantar flexors were measured using ultrasonography. All subjects were genotyped for COL1A1, COL5A1, GDF5, and MMP3 single nucleotide polymorphisms. For COL1A1, all subjects had GG genotype. For COL5A1, maximal tendon elongation and strain of individuals with a CC genotype were significantly greater than individuals with other genotypes (combined TT and CT) for knee extensors, but not for plantar flexors. For GDF5 and MMP3, there were no differences in the mechanical properties of tendon structures in knee extensors and plantar flexors among the three genotypes.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Blood circulation of patellar and Achilles tendons during contractions and heating2012

    • Author(s)
      Kubo K, Ikebukuro T
    • Journal Title

      Med Sci Sports Exer

      Volume: 44 Issue: 11 Pages: 2111-2117

    • DOI

      10.1249/mss.0b013e31825fa82e

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Effects of duration of heating on blood circulation of human muscle and tendon in vivo2012

    • Author(s)
      Kubo K
    • Journal Title

      Gazzetta Medica Italiana

      Volume: 171 Pages: 731-737

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and mechanical properties of muscle and tendon in highly trained sprinters2011

    • Author(s)
      Kubo K, Ikebukuro T, Yata H, Tomita M, Okada M.
    • Journal Title

      J Appl Biomech

      Volume: 27 Pages: 336-344

    • URL

      http://journals.humankinetics.com/jab-back-issues/jab-volume-27-issue-4-november

    • Related Report
      2012 Final Research Report
  • [Journal Article] 重量挙げおよび陸上短距離選手における下肢筋群の筋厚と競技成績との関係2011

    • Author(s)
      池袋敏博,久保啓太郎,岡田純一,矢田秀昭,角田直也
    • Journal Title

      体力科学

      Volume: 60 Pages: 401-411

    • NAID

      10029340555

    • URL

      https://www.jstage.jst.go.jp/article/jspfsm/60/4/60_4_401/_pdf

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] 発育に伴う筋・腱特性の変化2011

    • Author(s)
      久保啓太郎
    • Journal Title

      体育の科学

      Volume: 61 Pages: 191-194

    • URL

      http://www.kyorin-shoin.co.jp/magazine.aspx?PID=Z1

    • Related Report
      2012 Final Research Report
  • [Journal Article] Morphological and mechanical properties of muscle and tendon in highly trained sprinters2011

    • Author(s)
      Kubo K, Ikebukuro T, Yata H, Tomita M, Okada M.
    • Journal Title

      Journal of Applied Biomechanics

      Volume: 27 Pages: 336-344

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト生体における腱組織の力学的特性に及ぼす遺伝子多型の影響2012

    • Author(s)
      久保啓太郎,池袋敏博,矢田秀昭,角田直也
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト生体における腱組織の力学的特性に及ぼす遺伝子多型の影響2012

    • Author(s)
      久保啓太郎
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 筋収縮の繰り返しおよび温熱刺激に伴う膝蓋腱およびアキレス腱における血液循環の部位差2010

    • Author(s)
      久保啓太郎,池袋敏博
    • Organizer
      第63回日本体育学会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://park.itc.u-tokyo.ac.jp/kubokeitaro/

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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