Effect of candidate gene polymorphisms on the tendon extensibility related to sport performances
| Project/Area Number |
23650386
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBO Keitaro 東京大学, 大学院・総合文化研究科, 准教授 (70323459)
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| Co-Investigator(Renkei-kenkyūsha) |
CHINO Kentaro 東京大学, 大学院・総合文化研究科, 助教 (30443245)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | トレーニング科学 / 腱 / ヒト生体 / 先天的 / 障害 / コラーゲン |
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| Research Abstract |
In the present study, we aimed to investigate the effects of injury-associated polymorphisms within these four genes on the mechanical properties of human tendon structures in vivo. One hundred Japanese males participated in this experiment. The mechanical properties of tendon structures in knee extensors and plantar flexors were measured using ultrasonography. All subjects were genotyped for COL1A1, COL5A1, GDF5, and MMP3 single nucleotide polymorphisms. For COL1A1, all subjects had GG genotype. For COL5A1, maximal tendon elongation and strain of individuals with a CC genotype were significantly greater than individuals with other genotypes (combined TT and CT) for knee extensors, but not for plantar flexors. For GDF5 and MMP3, there were no differences in the mechanical properties of tendon structures in knee extensors and plantar flexors among the three genotypes.
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Report
(3 results)
Research Products
(10 results)
