| Project/Area Number |
23650411
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Tohoku University |
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Principal Investigator |
MIZUTA Kentaro 東北大学, 大学院・歯学研究科, 講師 (40455796)
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| Co-Investigator(Kenkyū-buntansha) |
MASAKI Eiji 東北大学, 大学院・歯学研究科, 教授 (40221577)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 硫化水素 / 気管支喘息 / 気道リモデリング / 気管平滑筋 |
|---|
| Research Abstract |
We examined whether hydrogen sulfide inhibits contraction and MAP kinase phosphorylation in airway smooth muscle. NaSH, a donor of hydrogen sulfide, significantly inhibited acethylcholine-stimulated guinea pig airway smooth muscle contraction. In addition, NaSH inhibited ERK phosphorylation in human airway smoothmuscle cells.
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