Is hydrogen sulfide effective for asthma treatment?
Project/Area Number |
23650411
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Applied health science
|
Research Institution | Tohoku University |
Principal Investigator |
MIZUTA Kentaro 東北大学, 大学院・歯学研究科, 講師 (40455796)
|
Co-Investigator(Kenkyū-buntansha) |
MASAKI Eiji 東北大学, 大学院・歯学研究科, 教授 (40221577)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 硫化水素 / 気管支喘息 / 気道リモデリング / 気管平滑筋 |
Research Abstract |
We examined whether hydrogen sulfide inhibits contraction and MAP kinase phosphorylation in airway smooth muscle. NaSH, a donor of hydrogen sulfide, significantly inhibited acethylcholine-stimulated guinea pig airway smooth muscle contraction. In addition, NaSH inhibited ERK phosphorylation in human airway smoothmuscle cells.
|
Report
(3 results)
Research Products
(28 results)