| Project/Area Number |
23650438
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MINAMISAWA Susumu 横浜市立大学, 医学(系)研究科(研究院) (40257332)
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| Co-Investigator(Renkei-kenkyūsha) |
QIBIN Jiao 早稲田大学, 理工学術院, 助手 (20581127)
NAGANO Yasuharu 新潟医療福祉大学, 健康科学部健康スポーツ学科, 講師 (00548282)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 廃用性筋萎縮 / 後肢懸垂 / 鍼通電療法 / Atrogin-1 / MuRF1 / atrogin-1 / 鍼通電 / 筋萎縮 / マウスモデル / 健康増進 |
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| Research Abstract |
To clarify the mechanism of preventing skeletal muscle atrophy, we adopted the skeletal muscle atrophy models with the hind limb suspension or the novel spiral wire immobilization. By acupuncture interventions, we found that acupuncture treatments improved the expression levels of target genes such as Atrogin-1 and MuRF1 of E3 ubiquitin ligases. Furthermore, cDNA microarray analysis clarified new candidate genes involved in acupuncture treatment to prevent skeletal muscle atrophy, including CCL21 and matrix metal proteinases.
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