Role of endoplasmic reticulum stress response in lifestyle diseases caused by unhealthy diet
| Project/Area Number |
23650481
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OYADOMARI Seiichi 徳島大学, 疾患プロテオゲノム研究センター, 教授 (90502534)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 体内時計 / 小胞体ストレス応答 / PERK / eIF2αリン酸 / 食生活リズム / eIF2αリン酸化 |
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| Research Abstract |
Dysfunction of the circadian clock not only causes jet lag but also exacerbates metabolic diseases. Inadequate food intake leads to disturb circadian rhythm but little is known about the molecular mechanism of this relationship. Our study show thathepatic PERK-eIF2alpha signaling is activated by food intake and can regulate the expression of circadian factor genes. We postulate that the ER stress response could serve to link physiologic perception of the environment to the circadian oscillatory apparatus.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses2011
Author(s)
Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, HasegawaY, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H
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Journal Title
Circulation
Volume: 124
Issue: 7
Pages: 830-839
DOI
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Peer Reviewed
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[Presentation] 小胞体ストレスと糖尿病2011
Author(s)
親泊 政一
Organizer
第84回日本内分泌学会学術総会
Place of Presentation
神戸国際会議場 (兵庫県)(招待講演)
Year and Date
2011-04-21
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