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Disease-specific intestinal nutrient sensing mechanismand the development of special nutrition foods

Research Project

Project/Area Number 23650482
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

YAMAMOTO Hironori  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60314861)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords特殊栄養食品 / 栄養センシング / 生活習慣病 / 腸管遺伝子 / トランスクリプトーム / 栄養素センシング
Research Abstract

In this study, we established disease-specific intestinal nutrient sensing mechanism and a basis for the development of special nutritious food. I identified renal disease-specific nutrient sensor genes and gene database using DNA microarray analysis. In addition, administration of phosphorus restricted diet to renal failure animal model, found that to prevent the development of ectopic calcification and calcium metabolism abnormality, also effective in the prevention of renal anemia.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (14 results)

  • [Journal Article] Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats2012

    • Author(s)
      Tan Vu Van, et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 51 Issue: 1 Pages: 27-32

    • DOI

      10.3164/jcbn.11-96

    • NAID

      130004879287

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病時におけるビタミン D 代謝異常の解明とリン制限食の治療効果2013

    • Author(s)
      田尻真梨、山本浩範、中橋乙起、香川知博、竹谷豊、佐々木一、武田英二
    • Organizer
      第16回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都国際会議場、(京都府)
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性腎不全時のリン制限食を用いた栄養療法は、腎性貧血の発症進展を予防する2012

    • Author(s)
      中尾真理、山本浩範、中橋乙起、阿部航太郎、竹谷豊、武田英二
    • Organizer
      第245回徳島医学会学術集会
    • Place of Presentation
      徳島県医師会館、(徳島県)
    • Year and Date
      2012-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Dietary Phosphate Restriction Prevents Renal Anemia in Chronic Kidny Disease Model Rats2012

    • Author(s)
      Nakao M, Yamamoto H, Nakahashi O, Kozai M, Taketani Y, Takeda E
    • Organizer
      The American Society of Nephrology (ASN) Meeting, Kidney week 2012
    • Place of Presentation
      SanDiego Convention Center (サンディエゴ、アメリカ合衆国)
    • Related Report
      2012 Final Research Report
  • [Presentation] THE EXPRESSION PROFILING OF INTESTINAL NUTRIENT TRANSPORTER GENES IN RATS WITH RENAL FAILURE2012

    • Author(s)
      Yamamoto H, Kikuchi H, Nakao M, Nakahashi O, Tanaka S, Taketani Y, Takeda E
    • Organizer
      the XVI International Congress on Nutrition and Metabolism in Renal Disease 2012 the First World Renal Nutrition Week
    • Place of Presentation
      Hilton Hawaiian Village(ホノルル ハワイ、アメリカ合衆国)
    • Related Report
      2012 Final Research Report
  • [Presentation] CKD モデルラットにおける血管内皮機能障害に対する炭酸ランタンの効果2012

    • Author(s)
      上田遥香、Abuduli Maerjianghan、山本浩範、竹谷豊、武田英二
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜、(神奈川県)
    • Related Report
      2012 Final Research Report
  • [Presentation] リン制限食による腎性貧血改善効果2012

    • Author(s)
      中尾真理、山本浩範、中橋乙起、池田翔子、香西美奈、田中更沙、竹谷豊、武田英二
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学、(宮城県)
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性腸疾患の発症および治癒過程におけるリン摂取量の重要性2012

    • Author(s)
      十河未来、山本浩範、香西美奈、中橋乙起、池田翔子、大谷彩子、竹谷豊、武田英二
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学、(宮城県)
    • Related Report
      2012 Final Research Report
  • [Presentation] リン制限食による腎性貧血の改善効果2012

    • Author(s)
      中尾真理、山本浩範、中橋乙起、池田翔子、香西美奈、田中更紗、竹谷豊、武田英二
    • Organizer
      第15回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都国際会議場、(京都府)
    • Related Report
      2012 Final Research Report
  • [Presentation] THE EXPRESSION PROFILING OF INTESTINAL NUTRIENT TRANSPORTER GENES IN RATS WITH RENAL FAILURE2012

    • Author(s)
      Yamamoto H et al
    • Organizer
      XVI International Congress on Nutrition and Metabolism in Renal Disease 2012 the First World Renal Nutrition Week
    • Place of Presentation
      Hilton Hawaiian Village, Honolulu, Hawaii (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dietary Phosphate Restriction Prevents Renal Anemia in Chronic Kidny Disease Model Rats2012

    • Author(s)
      Nakao M et al
    • Organizer
      ASN Kidney week 2012
    • Place of Presentation
      SanDiego Convention Center, SanDiego (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of Phosphate Homeostasis by Steroid/thyroid Hormones and Its Receptors2011

    • Author(s)
      Yamamoto H, Masuda M, Kozai M, Taketani Y, Miyamoto K, Takeda E
    • Organizer
      The International Conference on Food Factors 2011 (ICoFF 2011)
    • Place of Presentation
      台北国際会議中心、(台北、台湾)
    • Related Report
      2012 Final Research Report
  • [Presentation] Flavonoid Derivatives Prevent Disuse Muscle Atrophy2011

    • Author(s)
      Mukai R, Kawamura T, Nemoto H, Nikawa T, Yamamoto H, Takeda E, Terao J
    • Organizer
      The International Conference on Food Factors 2011 (ICoFF 2011)
    • Place of Presentation
      台北国際会議中心、(台北、台湾)
    • Related Report
      2012 Final Research Report
  • [Presentation] Dietary quercetin and onion powder could prevent immobilization induced bone loss in rats2011

    • Author(s)
      Yamamoto H, Tsuji M, Mukai R, Inakuma T, Terao J, Takeda E
    • Organizer
      第5回ポリフェノールと健康国際会議(ICPH)
    • Place of Presentation
      Hotel Melia、Sitges、Barcelona(スペイン)
    • Related Report
      2012 Final Research Report
  • [Presentation] リン制限食による腎性貧血の改善効果

    • Author(s)
      中尾真理
    • Organizer
      第15回日本病態栄養学会年次学術集会
    • Place of Presentation
      国際会館(京都府)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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