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Functional analysis of circulating-microRNA in metabolic state of between distant organs

Research Project

Project/Area Number 23650484
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionNagasaki University

Principal Investigator

MORI Ryoichi  長崎大学, 大学院・医歯薬学総合研究科, 講師 (30509310)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsカロリー制限 / 分泌型 microRNA / 次世代シークエンシング / 老化 / 代謝 / 肥満 / 全反射蛍光顕微鏡 / 生細胞ライブイメージング / 分泌型 miRNA / 次世代シークエンサー
Research Abstract

Blood contains large numbers of circulating miRNAs (c-miRNAs). However, it is not clear whether obesity- or calorie restriction alter the expression levels of c-miRNAs compared with wild-type mice. To elucidate the physiological significance of c-miRNAs, the expression levels of several c-miRNAs were observed to change, suggesting that these c-miRNAs are involved in aging and metabolic disorders. Thus, identification of c-miRNAs in the blood could be useful for diagnosis and for the identification of therapeutic targets in lifestyle disease patients.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (24 results) Book (2 results)

  • [Journal Article] Reporter bioassay systems for the phenotypic screening of candidate drugs2012

    • Author(s)
      Chiba T, Tsuchiya T, Mori R,Shimokawa I
    • Journal Title

      Sensors

      Volume: 12 Issue: 2 Pages: 1648-1656

    • DOI

      10.3390/s120201648

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Release of tumor necrosis factor-alpha from macrophages is mediated by small GTPase Rab372011

    • Author(s)
      Mori R, Ikematsu K, Kitaguchi T, Kim SE, Okamoto M, Chiba T, Miyawaki A, Shimokawa I, Tsuboi T
    • Journal Title

      European Journal of Immunology

      Volume: 41 Issue: 11 Pages: 3230-3239

    • DOI

      10.1002/eji.201141640

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] マクロファージからのサイトカイン分泌に関与する低分子量 G タンパク質 Rab ファミリーの機能解析2011

    • Author(s)
      森 亮一、間所 俊介、Kim Sang Eun、小松 利光、千葉 卓哉、坪井 貴司、下川 功
    • Journal Title

      Biomedical Gerontology

      Volume: 35 Pages: 33-36

    • NAID

      10029692166

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] Acute stress response modified by modest inhibition of growth hormone axis : apotential machinery of the anti-aging effect of calorie restriction2011

    • Author(s)
      Komatsu T, Trindade LS, Chiba T, Hayashi H, Henmi T, Ushiroda Y, Mori R, Shimokawa I
    • Journal Title

      Mechanisms of Ageing and Development

      Volume: 132 Issue: 3 Pages: 103-109

    • DOI

      10.1016/j.mad.2011.01.002

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Identification of differentially expressed circulating microRNA-complexed with argonaute2 in blood plasma of calorie restriction and high fat diet-induced obese mice by next generation sequencing2012

    • Author(s)
      Ryoichi Mori
    • Organizer
      The 2nd Pusan-Nagasaki Joint Seminar on Aging Research
    • Place of Presentation
      Pusan(Koria)
    • Year and Date
      2012-02-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代シーケンサーを用いたカロリー制限及び肥満マウス血漿中に存在する microRNA の網羅的同定2012

    • Author(s)
      森 亮一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県)
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定及び機能解析2012

    • Author(s)
      森 亮一
    • Organizer
      第42回日本創傷治癒学会
    • Place of Presentation
      かでる2.7(北海道)
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of Argonute2-circulating microRNA complexes in blood plasma of calorie-restricted and high fat diet-induced obese mice2012

    • Author(s)
      Ryoichi Mori
    • Organizer
      The 4th EMBO meeting
    • Place of Presentation
      Nice(France)
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of Argonute2-circulating microRNA complexes in blood plasma of calorie-restricted and high fat diet-induced obese mice2012

    • Author(s)
      森 亮一
    • Organizer
      第4回日本RNAi研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of Argonute2-circulating microRNA complexes in blood plasma of calorie-restricted and high fat diet-induced obese mice2012

    • Author(s)
      Ryoichi Mori
    • Organizer
      International Symposium of Asian Association of Aging Research 2012 in Fukuoka - Biology of Aging and Disorders-
    • Place of Presentation
      Tsukushi Kaikan(Fukuoka)
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定及び機能解析2012

    • Author(s)
      森 亮一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代シーケンサーを用いたカロリー制限及び肥満マウス血漿中に存在する microRNA の網羅的同定2012

    • Author(s)
      森 亮一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定及び機能解析2012

    • Author(s)
      森 亮一
    • Organizer
      第42回日本創傷治癒学会
    • Place of Presentation
      かでる2.7(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of Argonute2-circulating microRNA complexes in blood plasma of calorie-restricted and high fat diet-induced obese mice2012

    • Author(s)
      Ryoichi Mori
    • Organizer
      The 4th EMBO meeting
    • Place of Presentation
      Nice(France)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of Argonute2-circulating microRNA complexes in blood plasma of calorie-restricted and high fat diet-induced obese mice2012

    • Author(s)
      森 亮一
    • Organizer
      第4回日本 RNAi 研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of Argonute2-circulating microRNA complexes in blood plasma of calorie-restricted and high fat diet-induced obese mice2012

    • Author(s)
      Ryoichi Mori
    • Organizer
      International Symposium of Asian Association of Aging Research 2012 in Fukuoka - Biology of Aging and Disorders-
    • Place of Presentation
      Tsukushi Kaikan(Fukuoka)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定及び機能解析2012

    • Author(s)
      森 亮一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] dentification of differentially expressed circulating microRNA-complexed with argonaute2 in blood plasma of calorie restriction and high fat diet-induced obese mice by next generation sequencing2012

    • Author(s)
      森 亮一
    • Organizer
      The 2nd Pusan-Nagasaki Joint Seminar on Aging Research
    • Place of Presentation
      Pusan, Koria
    • Related Report
      2011 Research-status Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定2011

    • Author(s)
      森 亮一
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定2011

    • Author(s)
      森 亮一
    • Organizer
      第3回日本RNAi研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Related Report
      2012 Final Research Report
  • [Presentation] マクロファージのサイトカイン分泌に関与する低分子量 G蛋白質 Rab familyの機能解析2011

    • Author(s)
      森 亮一
    • Organizer
      第34回日本基礎老化学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular mechanisms for TNFα secretion from macrophages2011

    • Author(s)
      Ryoichi Mori
    • Organizer
      Gordon Research Conferences -Tissue Repair & Regeneration
    • Place of Presentation
      New Hampshire(USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] マクロファージにおける tumor necrosis factor-αの分泌は低分子量 G蛋白質 Rab37によって制御される2011

    • Author(s)
      森 亮一
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Final Research Report
  • [Presentation] マクロファージにおける tumor necrosis factor-α の分泌は低分子量 G 蛋白質 Rab37 によって制御される2011

    • Author(s)
      森 亮一
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Molecular mechanisms for TNFα secretion from macrophages2011

    • Author(s)
      森 亮一
    • Organizer
      Gordon Research Conferences -Tissue Repair & Regeneration
    • Place of Presentation
      New Hampshire, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] マクロファージのサイトカイン分泌に関与する低分子量 G 蛋白質 Rab family の機能解析2011

    • Author(s)
      森 亮一
    • Organizer
      第34回日本基礎老化学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定2011

    • Author(s)
      森 亮一
    • Organizer
      第3回日本 RNAi 研究会
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Presentation] 皮膚創傷治癒過程における炎症反応特異的 microRNA の同定2011

    • Author(s)
      森 亮一
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Book] レスベラトロールの基礎と応用第7章 サーチュインと老化、寿命2012

    • Author(s)
      下川 功、千葉 卓哉、森 亮一
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] レスベラトロールの基礎と応用 第7章 サーチュインと老化(分担)2012

    • Author(s)
      下川 功
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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