Functional analysis of circulating-microRNA in metabolic state of between distant organs
| Project/Area Number |
23650484
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORI Ryoichi 長崎大学, 大学院・医歯薬学総合研究科, 講師 (30509310)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | カロリー制限 / 分泌型 microRNA / 次世代シークエンシング / 老化 / 代謝 / 肥満 / 全反射蛍光顕微鏡 / 生細胞ライブイメージング / 分泌型 miRNA / 次世代シークエンサー |
|---|
| Research Abstract |
Blood contains large numbers of circulating miRNAs (c-miRNAs). However, it is not clear whether obesity- or calorie restriction alter the expression levels of c-miRNAs compared with wild-type mice. To elucidate the physiological significance of c-miRNAs, the expression levels of several c-miRNAs were observed to change, suggesting that these c-miRNAs are involved in aging and metabolic disorders. Thus, identification of c-miRNAs in the blood could be useful for diagnosis and for the identification of therapeutic targets in lifestyle disease patients.
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Report
(3 results)
Research Products
(30 results)
