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Analysis of the ability for memory-learning from a stand point of nutrrhythm and its basic research for prevention of senile dementia

Research Project

Project/Area Number 23650490
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionKagawa Nutrition University

Principal Investigator

HORIE Shuichi  女子栄養大学, 栄養学部, 教授 (60157063)

Co-Investigator(Renkei-kenkyūsha) FUKUSHIMA Mami  女子栄養大学, 栄養学部, 助教 (30286885)
HIRAISHI Sayuri  女子栄養大学, 栄養科学研究所, 助教 (20150659)
KAGAWA Yasuo  女子栄養大学, 栄養学部, 教授 (30048962)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords食行動 / 認知症 / 記憶学習能力 / 高脂肪食 / 時計遺伝子 / 脳機能 / 時間栄養学 / 制限給餌 / 野菜摂取 / 記憶学習
Research Abstract

We examined the effect of a high-fat (HF) diet on learning and memory functions in clock-mutant mice (clock) comparing its wild mice (wild) by measuring passive avoidance test (PAT) and by using Morris Water Maze apparatus. In the results, not only clockmice fed on the control diet, but also wild female mice fed on the HF diet were impaired the retention for PAT. It became obvious that female mice, with respect to memory retention, are more susceptible to HF diet and that entrainment of the peripheral circadian rhythm is essential for maintenance of learning and memory functions in mice.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2013 2012 2011 Other

All Journal Article (6 results) Presentation (16 results) (of which Invited: 1 results) Book (2 results) Remarks (2 results)

  • [Journal Article] 時間栄養学(栄養学と時間生物学のコラボレーション)2011

    • Author(s)
      堀江修一
    • Journal Title

      日本栄養士会雑誌

      Volume: 54(4) Pages: 32-35

    • Related Report
      2012 Final Research Report
  • [Journal Article] 時間栄養学(食事で体内時計を制御する1:肥満症の時間栄養学)2011

    • Author(s)
      堀江修一
    • Journal Title

      日本栄養士会雑誌

      Volume: 54(5) Pages: 33-36

    • Related Report
      2012 Final Research Report
  • [Journal Article] 時間栄養学(食事で体内時計を制御する2:血栓症の時間栄養学)2011

    • Author(s)
      堀江修一
    • Journal Title

      日本栄養士会雑誌

      Volume: 54(6) Pages: 36-39

    • Related Report
      2012 Final Research Report
  • [Journal Article] 時間栄養学 <連載第1回 栄養学と時間生物学のコラボレーション>2011

    • Author(s)
      堀江修一
    • Journal Title

      日本栄養士会雑誌

      Volume: 54(4) Pages: 32-35

    • Related Report
      2011 Research-status Report
  • [Journal Article] 時間栄養学 <連載第2回 食事で体内時計を制御する1:肥満症の時間栄養学>2011

    • Author(s)
      堀江修一
    • Journal Title

      日本栄養士会雑誌

      Volume: 54(5) Pages: 33-36

    • Related Report
      2011 Research-status Report
  • [Journal Article] 時間栄養学 <連載第3回 食事で体内時計を制御する2:血栓症の時間栄養学>2011

    • Author(s)
      堀江修一
    • Journal Title

      日本栄養士会雑誌

      Volume: 54(6) Pages: 36-39

    • Related Report
      2011 Research-status Report
  • [Presentation] 高脂肪食摂取マウスにおける血栓症関連因子の変動と運動負荷による影響2013

    • Author(s)
      中村紗佑里、堀江修一、平石さゆりら
    • Organizer
      第35回日本血栓止血学会
    • Place of Presentation
      山形
    • Year and Date
      2013-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂質食組成の差異に基づくマウスの脂質代謝の変動と血栓関連因子への影響2013

    • Author(s)
      中紗紗佑里、堀江修一、平石さゆりら
    • Organizer
      第133回日本薬学会
    • Place of Presentation
      神奈川
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂質食組成の差異に基づくマウスの脂質代謝の変動と血栓関連因子への影響2013

    • Author(s)
      中村紗佑里、紀室悠理、梶村佳世、平石さゆり、大石勝隆、堀江修一
    • Organizer
      第133回 日本薬学会
    • Place of Presentation
      神奈川
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高脂肪食摂取マウスにおける血栓症関連因子の変動と運動負荷による影響2013

    • Author(s)
      中村紗佑里、細野有希、平石さゆり、大石勝隆、堀江修一
    • Organizer
      第35回日本血栓止血学会
    • Place of Presentation
      山形
    • Related Report
      2012 Annual Research Report
  • [Presentation] 時間栄養学からみた食と睡眠2012

    • Author(s)
      堀江修一
    • Organizer
      第90回(公社)日本栄養・食糧学会関東支部大会(シンポジウム)
    • Place of Presentation
      埼玉
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Relation between a high-fat diet or the scheduled feeding and lung metastasis of melanoma B16BL6 in the mice2012

    • Author(s)
      堀江修一
    • Organizer
      第71回がん学会
    • Place of Presentation
      北海道
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 時間栄養学からみたマウスにおける抗血栓機能の変動2012

    • Author(s)
      堀江修一、平石さゆり、平岡真実ら
    • Organizer
      第13回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Nutrrhythm- dependent evaluation of high-fat deit on learning and memory in mice2012

    • Author(s)
      Shuichi HORIEet. Al
    • Organizer
      International Behavioral Neuroscience Society 21st Annual Meeting
    • Place of Presentation
      Hawaii、USA
    • Year and Date
      2012-06-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Nutrrhythm-dependent evaluation of high-fat deit on learning and memory in mice2012

    • Author(s)
      Shuichi HORIE、 Sayuri NAKAMURA、 Katsutaka OISHI
    • Organizer
      International Behavioral Neuroscience Society 21st Annual Meeting
    • Place of Presentation
      Kona, Hawaii
    • Related Report
      2012 Annual Research Report
  • [Presentation] 時間栄養学からみたマウスにおける抗血栓機能の変動2012

    • Author(s)
      堀江修一、平石さゆり、紀室悠理、平岡真実、大石勝隆
    • Organizer
      第13回Pharmaco-Hematology シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Relation between a high-fat diet or the scheduled feeding and lung metastasis of melanoma B16BL6 in the mice2012

    • Author(s)
      堀江修一
    • Organizer
      第71回癌学会
    • Place of Presentation
      北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] 時間栄養学からみた食と睡眠2012

    • Author(s)
      堀江修一
    • Organizer
      第90回(公社)日本栄養・食糧学会関東支部大会(シンポジウム)
    • Place of Presentation
      埼玉
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] マウス食餌中の脂肪酸組成の差異が血管内皮細胞の抗血栓性機能に及ぼす影響2011

    • Author(s)
      堀江修一、平石さゆり、平岡真実ら
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Augmentation of circadian PAI-1 expression in a ketogenic diet-fed PPARα-null mice : the possible involvement of PPARr activation in the induction2011

    • Author(s)
      Shuichi HORIEet.al
    • Organizer
      XXIIICongress of the Inter- national Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto、Japan
    • Year and Date
      2011-07-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Augmentation of circadian PAI-1 expression in a ketogenic diet-fed PPARα-null mice : the possible involvement of PPARγactivation in the induction2011

    • Author(s)
      S.HORIE, D.UCHIDA, N.OHKURA, K.OISHI
    • Organizer
      XXIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス食餌中の脂肪酸組成の差異が血管内皮細胞の抗血栓性機能に及ぼす影響2011

    • Author(s)
      堀江修一、平石さゆり、梶村佳世、平岡真実、大石勝隆
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Book] 栄養ケアと薬物療法、新臨床栄養学 栄養ケアマネジメント2011

    • Author(s)
      堀江修一
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 新臨床栄養学 栄養ケアマネジメント2011

    • Author(s)
      栄養ケアと薬物療法
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.eiyo.ac.jp/teachers/teacher.php?teacher_id=15

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.eiyo.ac.jp/teachers/teacher.php?teacher_id=15

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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