Screening of novel anticancer target molecules using vertebrate embryos
| Project/Area Number |
23650590
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | がん細胞の特性 / 胚発生 / アフリカツメガエル / 神経堤細胞 / 集団移動 / 可塑性 / トランスジェニック / ツメガエル |
|---|
| Research Abstract |
In order to identify novel anticancer chemicals, we developed new strategies to screen chemicals which modifies collective invasion of cranial neural crest cells of Xenopus embryos. From this screening, several chemicals were selected which also affects collective invasion of human cancer cells in vitro. We also established transgenic Xenopus which are available for monitoring the adult gut epithelial stem cells by genetically labeling with fluorescence.
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Report
(3 results)
Research Products
(30 results)
