Development and characterization of cancer stem cells from iPS cells
| Project/Area Number |
23650598
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
SENO Masaharu 岡山大学, 自然科学研究科, 教授 (90243493)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTANI Akifumi 岡山大学, 大学院・自然科学研究科, 助教 (50598331)
KUDOH Takayuki 岡山大学, 大学院・自然科学研究科, 助教 (00346412)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 幹細胞 / iPS細胞 / がん幹細胞 / 微小環境 / 分化 / 培養上清 / がん細胞培養上清 / 血管内皮細胞 / がん幹細胞ニッチ / 自己複製 / エクソソーム / マウスiPS細胞 / ヒトiPS細胞 |
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| Research Abstract |
It is widely recognized that cancer stem cells (CSCs) are responsible for initiation, metastasis, and recurrence of cancer. The lack of suitable model of CSCs was one of the limiting factors for the progress of CSC research while, for complete cure of cancer, CSCs are considered most important therapeutic targets. In this study, we have succeeded in establishing model cell lines of CSCs, into which was converted from iPS cells cultured under the cancerous conditions.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells2014
Author(s)
Chen L, Mizutani A, Kasai T, Yan T, Jin G, Vaidyanath A, El-Aarag BY, Liu Y, Kudoh T, Salomon DS, Fu L, Seno M
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Journal Title
Am J Cancer Res
Volume: 15; 4(1)
Pages: 80-8
URL
Related Report
Peer Reviewed
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[Journal Article] Cancer stem cells maintain a hierarchy of differentiation by creating their niche.2013
Author(s)
Matsuda S, Yan T, Mizutani A, Sota T, Hiramoto Y, Prieto-Vila M, Chen L, Satoh A, Kudoh T, Kasai T, Murakami H, Fu L, Salomon DS, Seno M
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Journal Title
Int J Cancer
Volume: 00
Issue: 1
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells.2013
Author(s)
Chen L, Mizutani A, Kasai T, Yan T, Jin G, Vaidyanath A, El-Aarag BY, Liu Y, Kudoh T, Salomon DS, Fu L, Seno M.
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Journal Title
American Journal of Cancer Research
Volume: 15
Pages: 80-88
Related Report
Peer Reviewed
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[Journal Article] A Model of Cancer Stem Cells Derived from Mouse Induced Pluripotent Stem Cells2012
Author(s)
Chen L, Kasai T, Li Y, Sugii Y, Jin G, Okada M, Vaidyanath A, Mizutani A, Satoh A, Kudoh T, Hendrix MJ, Salomon DS, Fu L, Seno M.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Enhanced intemalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand2011
Author(s)
Vaidyanath A, Hashizume T, Nagaoka T, Takeyasu N, Satoh H, Chen L, Wang J, Kasai T, Kudoh T, Satoh A, Fu L, Seno M
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Journal Title
J Cell Mol Med
Volume: 15
Issue: 11
Pages: 2525-2538
DOI
Related Report
Peer Reviewed
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[Presentation] Development and characterization of cancer stem cell model from mouse iPS cells2012
Author(s)
Chen L, Matsuda S, Kasai T, Sugii Y, Okada M, Igarashi K, Satoh A, Kudoh T, Fu L, Seno M
Organizer
American Association for Cancer Research, AACR annual meeting 2012
Place of Presentation
シカゴ
Related Report
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