Novel anticancer agents targeting tumor-promoting non-coding RNA
| Project/Area Number |
23650599
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KONDO Shigetada 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任助教 (40304513)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ノンゴーディングRNA / 悪性腫瘍 / ノンコーディングＲＮＡ / VEGF / 腫瘍血管新生 / 機能性RNA / ノンコーティングRNA / 血管新阻害剤 |
|---|
| Research Abstract |
I have investigated the direct effects of antiangiogenic agents on tumor cells, and revealed that treatment of cancer cells with vascular endothelial growth factor (VEGF)-targeting agents, including avastin and VEGF receptor multi kinase inhibitor, induced novel protein-non-coding RNAs. Overexpression of these non-coding RNAs made tumor cells resistant to anticancer drug- and hypoxia-induced apoptosis. In this research project, I developed two efficient siRNAs targeting novel tumor-promoting non-conding RNAs (ncRNAs). I evaluated efficacy ofthose siRNA on tumor cells and xenograft tumors. Knockdown of ncRNAs increased apoptosis of tumor cells by cytotoxic anticancer drugs (5-FU, cisplatin, etoposide). Furthermore, knockdown of ncRNAs in xenograft tumors enhanced antitumor effects of those cytotoxic anticancer agnets.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle Atrophy -Associated Ubiquitin Ligase Cbl-b2013
Author(s)
Abe T, Kohno S, Yama T, Ochi A, Suto T, Hirasaka K, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Choi I, Mukai R, Terao J, Nikawa T
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Journal Title
Int J Endocrinol
Volume: 2013
Pages: 907565-907565
DOI
Related Report
Peer Reviewed
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[Journal Article] An Intracellular Fragment of Osteoactivin Formed by Ectodomain Shedding Translocated to the Nucleoplasm and Bound to RNA Binding Proteins2012
Author(s)
Utsunomiya K, Owaki K, Okumura Y, Yano M, Oto T, Suzuki E, Tamura S, Abe T, Kohno S, Ohno A, Hirasaka K, Teshima-Kondoh S, Nikawa T
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Journal Title
Biosci Biotechnol Biochem
Volume: 76(12)
Pages: 2225-2229
Related Report
Peer Reviewed
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