| Project/Area Number |
23650601
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Keio University |
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Principal Investigator |
SAYA Hideyuki 慶應義塾大学, 医学部, 教授 (80264282)
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
|---|
| Keywords | 癌 / 遺伝子 / 細胞・組織 / 病理学 / シグナル伝達 |
|---|
| Research Abstract |
The step which cancer cells establish their metastatic lesions in other remote organs is dependent on the survival activity of cancer cells and the microenvironment of the secondary lesion. This project was conducted to clarify the molecular mechanism of the interaction between cancer cells and the premetastatic niche. We injected human breast cancer cells into mouse heart and obtained the brain metastasis lesions followed by the RNA-seq analysis of mRNA derived from both mouse cells and human cells. This experiments allowed us to identify the specific gene sets which may play a role in colonization of cancer cells in the secondary lesion.
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