The effects of mitochondrial complex II regulation onTumorigenesis
| Project/Area Number |
23650602
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | がん制御遺伝子 / エネルギー代謝 / ミトコンドリア / 酸化ストレス / 微小環境 / エピジェネティクス / ヒストン / 活性酸素 / 低酸素シグナル / メチル化 |
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| Research Abstract |
Recently, the cancer therapy and cancer prevention are very important in the medical field for the Japanese aging society. The SDHC gene which is encoding one of mitochondrial complex II subunit has been emphasized as a cancer regulatory gene. We focused on the effects of SDHC gene mutation on the tumorigenesis and carcinogenesis, and analyzed the energy metabolic and epigenetically histone modification changes in SDHC-mutated benign and malignant tumor process of spontaneous transformed cells.
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Report
(3 results)
Research Products
(44 results)
