| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Recently, the cancer therapy and cancer prevention are very important in the medical field for the Japanese aging society. The SDHC gene which is encoding one of mitochondrial complex II subunit has been emphasized as a cancer regulatory gene. We focused on the effects of SDHC gene mutation on the tumorigenesis and carcinogenesis, and analyzed the energy metabolic and epigenetically histone modification changes in SDHC-mutated benign and malignant tumor process of spontaneous transformed cells.
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