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Specific recovery of exhausted T cells against HTLV-1

Research Project

Project/Area Number 23650606
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor immunology
Research InstitutionHokkaido University

Principal Investigator

SHIDA Hisatoshi  北海道大学, 遺伝子病制御研究所, 教授 (00144395)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsHTLV-1 / 消耗T細胞 / 免疫療法 / ターゲッティング / CTL
Research Abstract

We constructed the molecule that specifically recognizes antiHTLV-1 Tax CTL. The cells that express both this molecule and measles virus F proteinare able to fuse with Tax CTL. The vector that possesses both this molecule and F proteinon its surface may be expected to specifically introduce the genes into Tax CTL.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating Vaccinia prime Sendai virus boost regimen and boosting by CD40Lm.2012

    • Author(s)
      Xianfeng Zhang, Tomoyoshi Sobue, Mao Isshiki, Shun-ichi Makino, Makoto Inoue, Kazunori Kato, Tatsuo Shioda, Takashi Ohashi, Jun Komano, Hideji Hanabusa Hisatoshi Shida
    • Journal Title

      Plos One

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of nucleocytoplasmic RNA transport during thelife cycle of retroviruses.2012

    • Author(s)
      Hisatoshi Shida
    • Journal Title

      Frontiers in Microbiology.

      Volume: 3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.2011

    • Author(s)
      Fofana IB, Colantonio AD, Reeves RK, Connole MA, Gillis JM, Hall LR, Sato S, Audin CR, Evans DT, Shida H, Johnson RP, Johnson WE
    • Journal Title

      J Immunol Methods.

      Volume: 370 Pages: 75-85

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus2011

    • Author(s)
      Mina Hikichi, Minoru Kidokoro, Takeshi Haraguchi, Hideo Iba, Hisatoshi Shida, Hideaki Tahara, Takafumi Nakamura
    • Journal Title

      Reduces Viral Pathogenicity without Impairing its Antitumor Efficacy. Mol. Ther.

      Volume: 19 Pages: 1107-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear and Cytoplasmic Effects of Human CRM1 on HIV-12011

    • Author(s)
      Mika Nagai-Fukataki, Takashi Ohashi, Iwao Hashimoto, Tominori Kimura, Yoshiyuki Hakata, Hisatoshi Shida
    • Journal Title

      Production in Rat Cells. Genes to Cells

      Volume: 16 Pages: 203-216

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear and Cytoplasmic Effects of Human CRM1 on HIV-1 Production in Rat Cells. Genes to Cells2011

    • Author(s)
      Mika Nagai-Fukataki, Takashi Ohashi, Iwao Hashimoto, Tominori Kimura, Yoshiyuki Hakata, Hisatoshi Shida
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 203-216

    • Related Report
      2011 Research-status Report
  • [Presentation] 弱毒ワクシニアプライム、センダイウイルスブーストエイズワクチン法の免疫評価およびhCD40Lmアジュバント効果の検討。2012

    • Author(s)
      張険峰
    • Organizer
      日本エイズ学会
    • Place of Presentation
      横浜慶応義塾大学日吉キャンパス
    • Year and Date
      2012-11-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Protection against highly pathogenic SIV by BCG-SIV recombinant priming and attenuated replicating vaccinia-SIV recombinant boosting2012

    • Author(s)
      Xianfeng Zhang, Hiromi Sakawaki, Tomoyuki Miura, Tatsuhiko Igarashi, Shigeo Horibata, Kaori Yokomizo, Kazuhiro Matsuo, Naoki Yamamoto, Ismael Ben Fofana, Welkin Johnson, Takashi Ohashi, Hisatoshi Shida
    • Organizer
      AIDS VCCINE2012.
    • Place of Presentation
      Convention Center,Boston, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Enhancement of CD40Lm on Vaccine Elicited Anti-HIV-1 Immunity2011

    • Author(s)
      Xianfeng Zhang, Tomoyoshi Sobue, Hisatoshi Shida
    • Organizer
      6th IAS Conference on HIV Pathogenesis, Treatment and Prevention.
    • Place of Presentation
      Rome, Italy.
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunogenicity of Lc16M8〓 Vaccinia Prime/Sendai Virus Vector Boost Targeting the Envelope Glycoprotein of HIV-1 and Contribution of CD40Lm2011

    • Author(s)
      Tomoyoshi Sobue, Shun-Ichi Makino, Xianfeng Zhang, Takashi Ohashi, Kazunori Kato, Tatsuo Shioda, Makoto Inoue, Mamoru Hasegawa, Hisatoshi Shida
    • Organizer
      XV International Congress of Virology.
    • Place of Presentation
      Sapporo Convention Center, Sapporo, Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunogenicity of LC16m8〓 Vaccinia Virus/Sendai Virus Vector Expressing the gp160 of HIV-1 and Effect of CD40Lm2011

    • Author(s)
      H. Shida
    • Organizer
      AIDS VCCINE 2011
    • Place of Presentation
      Intercontinental hotel, Bangkok Thailand
    • Related Report
      2012 Final Research Report
  • [Presentation] ラットT細胞へのHIV-1感染におけるCSA,As203の増強効果

    • Author(s)
      宮崎かや、張険峰、大橋貴、志田壽利
    • Organizer
      第25回日本エイズ第学会学術総会
    • Place of Presentation
      ハイアットリージェンシー東京 東京
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/molvir

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] ワクシニアウイルスベクターおよびセンダイウイルスベクターからなるプライム/ブーストワクチン用ウイルスベクター2013

    • Inventor(s)
      志田壽利、祖父江友芳、加藤和則、井上誠、長谷川護
    • Industrial Property Rights Holder
      国立大学法人北海道大学、北海道公立大学法人札幌医科大学、ディナベック株式会社
    • Filing Date
      2013-04-17
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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