Specific recovery of exhausted T cells against HTLV-1
| Project/Area Number |
23650606
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIDA Hisatoshi 北海道大学, 遺伝子病制御研究所, 教授 (00144395)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HTLV-1 / 消耗T細胞 / 免疫療法 / ターゲッティング / CTL |
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| Research Abstract |
We constructed the molecule that specifically recognizes antiHTLV-1 Tax CTL. The cells that express both this molecule and measles virus F proteinare able to fuse with Tax CTL. The vector that possesses both this molecule and F proteinon its surface may be expected to specifically introduce the genes into Tax CTL.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes.2011
Author(s)
Fofana IB, Colantonio AD, Reeves RK, Connole MA, Gillis JM, Hall LR, Sato S, Audin CR, Evans DT, Shida H, Johnson RP, Johnson WE
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Journal Title
J Immunol Methods.
Volume: 370
Pages: 75-85
Related Report
Peer Reviewed
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[Presentation] Protection against highly pathogenic SIV by BCG-SIV recombinant priming and attenuated replicating vaccinia-SIV recombinant boosting2012
Author(s)
Xianfeng Zhang, Hiromi Sakawaki, Tomoyuki Miura, Tatsuhiko Igarashi, Shigeo Horibata, Kaori Yokomizo, Kazuhiro Matsuo, Naoki Yamamoto, Ismael Ben Fofana, Welkin Johnson, Takashi Ohashi, Hisatoshi Shida
Organizer
AIDS VCCINE2012.
Place of Presentation
Convention Center,Boston, USA
Related Report
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[Presentation] Immunogenicity of Lc16M8〓 Vaccinia Prime/Sendai Virus Vector Boost Targeting the Envelope Glycoprotein of HIV-1 and Contribution of CD40Lm2011
Author(s)
Tomoyoshi Sobue, Shun-Ichi Makino, Xianfeng Zhang, Takashi Ohashi, Kazunori Kato, Tatsuo Shioda, Makoto Inoue, Mamoru Hasegawa, Hisatoshi Shida
Organizer
XV International Congress of Virology.
Place of Presentation
Sapporo Convention Center, Sapporo, Japan.
Related Report
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