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Development of positron emitter labeled agents for boron neutron capture therapy

Research Project

Project/Area Number 23650610
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Tumor diagnosis
Research InstitutionTohoku University

Principal Investigator

FUKUDA Hiroshi  東北大学, 加齢医学研究所, 教授 (30125645)

Co-Investigator(Kenkyū-buntansha) IWATA Ren  東北大学, サイクロトロンラジオアイソ トープセンター, 教授 (60143038)
FURUMOTO Shozo  東北大学, 大学院医学系研究科, 准教授 (00375198)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords分子イメージング / BNCT / がん / パラボロノフェニルアラニン(BPA) / PET / F-18 BPA / BNCT / BPA / PET
Research Abstract

In this study, we tried to establish a new practical method for synthesis of4-borono-2-fluoro-L-phenylalanine (FBPA) via nucleophilic substitution reaction with fluoride to apply it to preparation of 18F-FBPA. The strategy was that bromonitrobenzaldehyde was used as starting material and phenylalanine scaffold was constructed after nucleophilic a fluorination. We evaluated the reactions that compose the synthetic pathway. However, it turned out to be difficult to synthesize FBPA through the synthesis pathway especially due to the difficulty in introducing boronic acid group into the aryl ring.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (7 results)

  • [Journal Article] In vitro and in vivo characterization of 2-Deoxy-2- [^<18>F]Fluoro-D-Mannose as a tumor- imaging agent for positron emission tomography2013

    • Author(s)
      Furumoto S, Shinbo R, Iwata R, Ishikawa R, Yanai K, Yoshioka T, Fukuda H
    • Journal Title

      J. Nucl. Med.

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo characterization of 2-Deoxy-2-[18F]Fluoro-D-Mannose as a tumor-imaging agent for positron emission tomography2013

    • Author(s)
      Furumoto S
    • Journal Title

      J. Nucl. Med.

      Volume: accepted

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactivity of electrochemically concentrated anhydrous [^<18>F]Fluoride formicrofluidic radiosynthesis of 18F-labeled compounds2012

    • Author(s)
      Wong R, Iwata R, Saiki H, Furumoto S, Ishikawa Y, Ozeki E.
    • Journal Title

      Appl. Radiat. Isot

      Volume: 70 Pages: 193-199

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of [^<11>C]interleukin 8 using a cell-free translation system and L-[^<11>C] methionine2012

    • Author(s)
      Harada R, Furumoto S, Yoshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Yanai K.
    • Journal Title

      Nucl. Med. Biol

      Volume: 39 Pages: 155-160

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid biochemical synthesis of ^<11>C-labeled single chain variable fragment antibody forimmuno-PET by cell-free protein synthesis2012

    • Author(s)
      Matsuda T, Furumoto S, Higuchia K, Yokoyama J, Zhang M-R, Yanai K, Iwata R, Kigawa T.
    • Journal Title

      Bioorg. Med. Chem

      Volume: 20 Pages: 6579-6582

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple preparation and purification of ethanol-free solutions of 3'-deoxy-3'-[^<18>F] fluorothymidine ([^<18>F]FLT) by means of disposable solid-phase extraction cartridges2012

    • Author(s)
      Pascali1 C., Bogni A., Fugazza L., Cucchi C., Crispu O., Laera L., Iwata R., Maiocchi G., Crippa F., Bombardieri E.
    • Journal Title

      Nucl. Med. Biol

      Volume: 39 Pages: 540-550

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clairvivo PETを用いた小動物PET研究の実際2012

    • Author(s)
      古本祥三,田代学,岩田錬,谷内一彦
    • Journal Title

      RadFan

      Volume: 10 Pages: 59-62

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reactivity of electrochemically concentrated anhydrous [^<18>F]fluoride for microfluidic radiosynthesis of ^<18>F-labeled compounds2012

    • Author(s)
      Wong R., Iwata R., Saiki H., Furumoto S., Ishikawa Y., Ozeki E.
    • Journal Title

      Appl. Radiat. Isot

      Volume: 70 Issue: 1 Pages: 193-199

    • DOI

      10.1016/j.apradiso.2011.09.022

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simple preparation and purification of ethanol-free solutions of 3'-deoxy-3'- [^<18>F]fluorothymidine ([^<18>F]FLT) by means of disposable solid-phase extraction cartridges2012

    • Author(s)
      Pascali1 C., Bogni A., Fugazza L., Cucchi C., Crispu O., Laera L., Iwata R., Maiocchi G., Crippa F.,Bombardieri E.
    • Journal Title

      Nucl. Med. Biol

      Volume: 39 Issue: 4 Pages: 540-550

    • DOI

      10.1016/j.nucmedbio.2011.10.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clairvivo PETを用いた小動物PET研究の実際.2012

    • Author(s)
      古本祥三
    • Journal Title

      RadFan

      Volume: 10(12) Pages: 59-62

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Synthesis of [^(11)C]interleukin 8 using a cell-free translation system and l-[^(11)C]methionine2012

    • Author(s)
      Harada R, Furumoto S, Y oshikawa T, Ishikawa Y, Shibuya K, Okamura N, Iwata R, Y anai K
    • Journal Title

      Nucl Med Biol

      Volume: 39 Issue: 1 Pages: 155-160

    • DOI

      10.1016/j.nucmedbio.2011.07.005

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【分子イメージング薬剤の標的選択的動態制御】薬物動態評価のPET分子イメージング2011

    • Author(s)
      古本祥三,谷内一彦
    • Journal Title

      Drug Delivery System

      Volume: 26 Pages: 401-409

    • NAID

      130001274712

    • Related Report
      2012 Final Research Report
  • [Presentation] Bevacizumab increases anaerobic glycolysis on tumor2012

    • Author(s)
      Yoshioka T, Furumoto S., and Fukuda H
    • Organizer
      The 2012 SNM Annual Meeting
    • Place of Presentation
      マイアミ,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] PETイメージングによる薬物動態と薬効の評価2012

    • Author(s)
      古本祥三,谷内一彦
    • Organizer
      第28回日本DDS学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Bevacizumab increases anaerobic glycolysis on tumor2012

    • Author(s)
      Yoshioka T
    • Organizer
      The 2012 SNM Annual Meeting
    • Place of Presentation
      Miami, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ^<18>F-フロロデオキシマンノースの腫瘍イメージング剤としての特性評価2011

    • Author(s)
      古本祥三,新保亮,石川洋一,谷内一彦,岩田錬,福田寛
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of 2-[^<18>F]fluoro-2-deoxy-D-mannose([^<18>F]FDM) as a tumor imaging agent2011

    • Author(s)
      Furumoto S., Ryo Shinbo, Youichi Ishikawa, Kazuhiko Yanai, Ren Iwata, Fukuda H.
    • Organizer
      the 19th International Symposium on Radiopharmaceutical Sciences 2011
    • Place of Presentation
      アムステルダム,オランダ
    • Related Report
      2012 Final Research Report
  • [Presentation] 18F-フロロデオキシマンノースの腫瘍イメージング剤としての特性評価2011

    • Author(s)
      古本祥三、新保亮、石川洋一、谷内一彦、岩田錬、福田寛
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] Characterization of 2-[18F]fluoro-2-deoxy-D-mannose ([18F]FDM) as a tumor imaging agent2011

    • Author(s)
      Shoso Furumoto, Ryo Shinbo, Youichi Ishikawa, Kazuhiko Yanai, Ren Iwata, Hiroshi Fukuda
    • Organizer
      19th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      VU University Medical Center
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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