| Project/Area Number |
23650610
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUDA Hiroshi 東北大学, 加齢医学研究所, 教授 (30125645)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Ren 東北大学, サイクロトロンラジオアイソ トープセンター, 教授 (60143038)
FURUMOTO Shozo 東北大学, 大学院医学系研究科, 准教授 (00375198)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 分子イメージング / BNCT / がん / パラボロノフェニルアラニン(BPA) / PET / F-18 BPA / ＢＮＣＴ / ＢＰＡ / ＰＥＴ |
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| Research Abstract |
In this study, we tried to establish a new practical method for synthesis of4-borono-2-fluoro-L-phenylalanine (FBPA) via nucleophilic substitution reaction with fluoride to apply it to preparation of 18F-FBPA. The strategy was that bromonitrobenzaldehyde was used as starting material and phenylalanine scaffold was constructed after nucleophilic a fluorination. We evaluated the reactions that compose the synthetic pathway. However, it turned out to be difficult to synthesize FBPA through the synthesis pathway especially due to the difficulty in introducing boronic acid group into the aryl ring.
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