| Project/Area Number |
23650616
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOSHO Katsuhiko 札幌医科大学, 医学部, 助教 (10597339)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道扁平上皮癌 / DNA / メチル化 / microRNA / 背景粘膜 / 粘膜内癌 / DNAメチル化 / MCA microarray / LINE-1 |
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| Research Abstract |
The aim of this study was to profile methylation changes and identify methylated genes and to clarify the role of genome-wide hypomethylation in esophageal squamous cell carcinoma(ESCC).The degree of genome-wide CpG islands methylation increased from the normal healthy epithelium,through the ESCC-background non-neoplastic epithelium,to the carcinoma tissues.CpG island hypermethylation of tumor-related genes,especially that of the LRFN5 gene,and genome-wide hypomethylation appear to play important roles in ESCC pathogenesis irrespective of drinking and/or smoking habits.
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