Characterization of genetic factors that modify the risk of cancer and could be useful for the development of new cancer prevantion drugs

• Project/Area Number: 23650624
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Clinical oncology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: DAIGO YATARO 滋賀医科大学, 医学部, 教授 (30345029)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 分子標的治療

Research Abstract

Cancer is the most common cause of death in Japan, and its incidence is increasing worldwide. To identify genetic factors that modify the risk of human cancer and could be therapeutic targets for the development of new anti-cancer drugs, we conducted a genome-wide association study in a Japanese lung cancer population and identified some susceptibility genes for lung cancer. We established cell lines stably expressing these risk factor genes and examined their mechanism in cancer progression to make a new drug screening system. The results could contribute to new drug design targeting genetic variation that may influence susceptibility to human cancer.

Research Products

• [Journal Article] Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis (2014)
  • Author(s): T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura
  • Journal Title: International journal of oncology Volume: 45(1) Issue: 1 Pages: 147-56
  • DOI: 10.3892/ijo.2014.2418
  • Peer Reviewed / Open Access
• [Journal Article] A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses. (2013)
  • Author(s): Daigo Y, Takano A, Teramoto K, Chung S, Nakamura Y.
  • Journal Title: Clin Pharmacol Ther Volume: 94 Issue: 2 Pages: 218-223
  • DOI: 10.1038/clpt.2013.90
  • Peer Reviewed
• [Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. (2013)
  • Author(s): Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
  • Journal Title: Mol Cancer Res Volume: 11 Issue: 8 Pages: 937-951
  • DOI: 10.1158/1541-7786.mcr-12-0685-t
  • Peer Reviewed
• [Journal Article] Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition. (2013)
  • Author(s): Kogure M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, Kobayashi T, Daigo Y, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.
  • Journal Title: Cancer Letters Volume: 336 Issue: 1 Pages: 76-84
  • DOI: 10.1016/j.canlet.2013.04.009
  • Peer Reviewed
• [Journal Article] A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population (2012)
  • Author(s): Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, Ohnami S, Shimada Y, Ashikawa K, Saito A, Watanabe S, Tsuta K, Kamatani N, Yoshida T, Nakamura Y, Yokota J, Kubo M, Kohno T
  • Journal Title: Nature Genetics Volume: 44 Issue: 8 Pages: 900-903
  • DOI: 10.1038/ng.2353
  • Peer Reviewed
• [Journal Article] Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis (2012)
  • Author(s): T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura
  • Journal Title: Cancer research Volume: 72(16) Issue: 16 Pages: 4110-8
  • DOI: 10.1158/0008-5472.can-12-0159
  • Peer Reviewed
• [Journal Article] Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of aurora kinase B (2012)
  • Author(s): Hyun-Soo Cho, Shinya Hayami, Gouji Toyokawa, Kazuhiro Maejima, Yuka Yamane, Takehiro Suzuki, Naoshi Dohmae, Masaharu Kogure, Daechun Kang, David E, Neal, Bruce, A. J. Ponder, Hiroki Yamaue, Yusuke Nakamura, Ryuji Hamamoto
  • Journal Title: Nature Communications Volume: 3 Issue: 1 Pages: 1072-1072
  • DOI: 10.1038/ncomms2074
  • Peer Reviewed
• [Journal Article] Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis (2012)
  • Author(s): M. H. Nguyen, K. Ueda, Y. Nakamura, and Y. Daigo
  • Journal Title: International journal of oncology Volume: 41(4) Issue: 4 Pages: 1285-96
  • DOI: 10.3892/ijo.2012.1589
  • Peer Reviewed
• [Journal Article] Regulation of histone modification and chromatin structure by the p53-PADI4 pathway (2012)
  • Author(s): Tanikawa C, Espinosa M, Suzuki A, Masuda K, Yamamoto K, Tsuchiya E, Ueda K, Daigo Y, Nakamura Y, Matsuda K.
  • Journal Title: Nat Commun. Volume: 3 Issue: 1 Pages: 676-676
  • DOI: 10.1038/ncomms1676
  • Peer Reviewed
• [Presentation] がんの分子病態研究に基づいた個別化医療開発 (2013)
  • Author(s): 醍醐 弥太郎
  • Organizer: 第761回千葉県がんセンター集談会
  • Place of Presentation: 千葉
  • Year and Date: 2013-12-17
• [Presentation] がんの分子病態研究に基づいた個別化医療開発 (2013)
  • Author(s): 醍醐弥太郎
  • Organizer: 第761回千葉県がんセンター研究所集談会
  • Place of Presentation: 千葉県がんセンター (千葉県）
  • Invited
• [Presentation] Genome-wide association study of lung cancer : Variation in TP63 gene confers the risk of lung adenocarcinoma (2012)
  • Author(s): Yataro Daigo, Daiki Miki, Yusuke Nakamura
  • Organizer: 103th AACR Annual meeting
  • Place of Presentation: McCormick Place Convention Center (Chicago, USA)
  • Year and Date: 2012-04-02
• [Presentation] Genome-wide association study of lung cancer: Variation in TP63 gene confers the risk of lung adenocarcinoma (2012)
  • Author(s): Yataro Daigo, Daiki Miki, Yusuke Nakamura
  • Organizer: 103th AACR Annual meeting
  • Place of Presentation: McCormick Place Convention Center (Chicago, USA)
• [Presentation] VARIATION IN TP63 GENE CONFERS THE RISK OF LUNG ADENOCARCINOMA INTHE EAST ASIAN POPULATION (2011)
  • Author(s): Yataro Daigo, Yusuke Nakamura
  • Organizer: THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP
  • Place of Presentation: 京都
  • Year and Date: 2011-10-25
  • Invited
• [Presentation] Genome-wide association study of lung cancer : Association of variation in TP63 with lung adenocarcinoma susceptibility (2011)
  • Author(s): Yataro Daigo, Yusuke Nakamura
  • Organizer: 日本癌学会第70回総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
  • Invited
• [Presentation] VARIATION IN TP63 GENE CONFERS THE RISK OF LUNG ADENOCARCINOMA INTHE EAST ASIAN POPULATION. (2011)
  • Author(s): Yataro Daigo, Yusuke Nakamura
  • Organizer: THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP(招待講演)
  • Place of Presentation: 京都
• [Presentation] Genome-wide association study of lung cancer: Association of variation in TP63 with lung adenocarcinoma susceptibility. (2011)
  • Author(s): Yataro Daigo, Yusuke Nakamura
  • Organizer: 日本癌学会第70回総会(招待講演)
  • Place of Presentation: 名古屋
• [Book] 呼吸 (2013)
  • Author(s): 醍醐 弥太郎
  • Total Pages: 106
  • Publisher: 呼吸研究
• [Book] 呼吸 (2013)
  • Author(s): 醍醐弥太郎
  • Total Pages: 106
  • Publisher: 呼吸研究
• [Book] 日本臨床 (2012)
  • Author(s): 醍醐 弥太郎
  • Total Pages: 180
  • Publisher: 日本臨床社
• [Book] 日本臨床 (2012)
  • Author(s): 醍醐 弥太郎
  • Total Pages: 180
  • Publisher: 日本臨床社
• [Book] カレントセラピー (2011)
  • Author(s): 醍醐 弥太郎
  • Total Pages: 90
  • Publisher: ライフメディコム社
• [Book] カレントセラピー (2011)
  • Author(s): 醍醐弥太郎
  • Total Pages: 90
  • Publisher: ライフメディコム社