| Project/Area Number |
23650628
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
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| Keywords | 抗がん物質検索・ケミカルバイオロジー / がん転移モデル / がん転移 / anoikis / 細胞外マトリクス / CEACAMファミリー / 抗体 |
|---|
| Research Abstract |
The aim of this project is to make a novel metastatic model in cancer for searching the anti-metastatic agent, that works by preventing the interaction between tumor cells and the target organ. The reduction of cell number interacting with collagen IV, an extracellular matrix, was observed in this model using HLC-1 cells with less amount of CEACAM6 on the cellular surface generated by shRNA, meanings that this model system might be a useful tool for searching a novel metastatic inhibitor.
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