| Project/Area Number |
23650632
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cancer epidemiology and prevention
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
OTAKE Yosuke 独立行政法人国立がん研究センター, 中央病院, 医員 (20385644)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Yutaka 独立行政法人国立がん研究センター, 中央病院, 科長 (90501859)
MURAMATSU Yukio 独立行政法人国立がん研究センター, がん予防・検診研究センター, 部長 (40501870)
MATSUDA Takahisa 独立行政法人国立がん研究センター, 中央病院, 医長 (30508049)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 大腸腺腫性ポリープ / 大腸癌 / advanced neoplasia / コホート研究 / 大腸内視鏡検査 / non-referral strategy / 大腸微小腺腫性ポリープ |
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| Research Abstract |
In this longitudinal study, we assess the incidence of advanced neoplasia detected during follow-up colonoscopies in patients who were found to have diminutive (<5 mm) adenomatous polyps during initial screening colonoscopies but were not referred for removal. Advanced neoplasia was defined as low-grade dysplasia more than 10 mm, adenoma with a high-grade dysplasia component, or carcinoma. Advanced neoplasia was detected in 20 (2.8%; 95% CI 1.6 to 4.0) of 713 such patients during follow-up colonoscopies over a median interval of 61 months. Only one patient with advanced neoplasia needed surgical treatment, however, such lesions in remaining 19 patients were curatively treated by endoscopic resection. Risk of advanced neoplasia was not increased even when diminutive adenomatous polyps had been untreated at screening. Our non-referral strategy was considered to be acceptable, provided such patients undergo recommended follow-up colonoscopies.
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