| Project/Area Number |
23651045
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
KOMATSU Kenshi 京都大学, 放射線生物研究センター, 教授 (80124577)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 感受性 / 小頭症 / 放射線 / 大脳神経幹細胞 / 中心体 / アポトーシス / NBS1 / apical / basal |
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| Research Abstract |
The incidence of radiation microcephaly is 10-fold higher than that of radiation carcinogenesis. We showed her that radiation induces the apoptosis in basal neuro-progenitor cells, and develops radiation microcephaly. Simultaneously, apoptosis was observed in apical neuro-progenitor cells, which produce basal neuro-progenitor cells by cell proliferation through attachment of centrosomes to apical layers. These evidences suggest that proliferation is critical to develop radiation apososis, because defect in maintaining centrosomes induces the microcephaly in a patient with Nijmege breakage syndrome.
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