The role of DNA damage induced chromatin dynamics in the establishment and maintenance of pluripotency of stem cells
Project/Area Number |
23651047
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Risk sciences of radiation/Chemicals
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Research Institution | Kyoto University |
Principal Investigator |
IKURA Masae 京都大学, 放射線生物研究センター, 研究員 (40535275)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | TIP60ヒストンアセチル化酵素 / ヒストンH2AX / 細胞の多能性 / iPS細胞 / DNA損傷応答 |
Research Abstract |
We have previously shown that TIP60 histone acetyltransferase complex regulates histone H2AX eviction upon DNA damage, which facilitate DNA damage response signaling. In this study, we tested whether chromatin dynamics via H2AX regulated by TIP60 is involved in the establishment or maintenance of pluripotency of stem cells including iPS cells. As a result, we found that TIP60 is not involved in the establishment of pluripotency of iPS cells.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions (2011)2011
Author(s)
Takaku, M., Tsujita, T., Horikoshi, N., Takizawa, Y., Qing, Y., Hirota, K., Ikura, M., Ikura, T., Takeda, S., Kurumizaka, H.
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Journal Title
Biochemistry
Volume: 50
Pages: 6797-6805
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[Presentation] SMN-GEMIN2 complex stimulates the RAD51-mediated recombination reactions
Author(s)
Takaku, M., Tsujita, T., Horikoshi, N., Takizawa, Y., Qing, Y., Hirota, K., Ikura, M., Ikura, T., Takeda, S., Kurumizaka, H.
Organizer
第34回日本分子生物学会年会
Place of Presentation
横浜
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