Establishment of radiation-carcinogenesis system using culturedthyroid follicular cells
| Project/Area Number |
23651048
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUZUKI Keiji 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (00196809)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線 / がん / 甲状腺 / 発がん / 幹細胞 |
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| Research Abstract |
We have isolated an immortalized cells derived from human thyroid follicles. These cells transcribe the PAX-8 gene but do not express any stem cell marker. After gamma-irradiation, cells were maintained at confluence to check focus formation. We observed dose-dependent foci formation, however, foci-derived cells lack transformed phenotypes, indicating that malignant conversion still requires additional genetic alterations
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction2011
Author(s)
Suzuki K, Mitsutake N, Saenko V, Suzuki M, Matsuse M, Ohtsuru A, Kumagai A, Uga T, Yano H, Nagayama Y, Yamashita S
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Journal Title
NAID
Related Report
Peer Reviewed
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