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Establishment of spatio-temporal analysis for low-dose-rateradiation-induced damage accumulation in tissue stem cells

Research Project

Project/Area Number 23651051
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research Institution一般財団法人電力中央研究所 (2012)
Central Research Institute of Electric Power Industry (2011)

Principal Investigator

OTSUKA Kensuke  一般財団法人電力中央研究所, 原子力技術研究所, 主任研究員 (50371703)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords放射線 / 組織 / 細胞 / 癌 / 発生 / 分化 / 遺伝子 / 幹細胞 / 低線量 / 腸管 / 組織・細胞 / 発生・分化 / ターンオーバー / 障害蓄積性
Research Abstract

Radiation-induced turnover of tissue stem cells was evaluated by genetic lineagetracing of intestinal tissue stem cells (Lgr5+ stem cells). X-rays induced loss of Lgr5+stem cells and reduced Lgr5 gene expression in the colon but not in the duodenum. Lossof colonic Lgr5+ stem cells seemed to be compensated by de novo production of Lgr5+ stemcells. These findings are important evidences to understand radiation-inducedcarcinogenesis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Ionizing Radiation Leads to the Replacement and de novo Production of Colonic Lgr5+ Stem Cells2013

    • Author(s)
      Kensuke Otsuka
    • Journal Title

      Radiation Research

      Volume: 179 Issue: 6 Pages: 637-646

    • DOI

      10.1667/rr3253.1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Evaluation of theradiation-induced turnover ofintestinal stem cells2012

    • Author(s)
      Kensuke Otsuka
    • Organizer
      Annual Meetingof Radiation Research Society
    • Place of Presentation
      Rio Mar Resort Hotel (アメリカ)
    • Year and Date
      2012-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of theradiation-induced turnover ofintestinal stem cells2012

    • Author(s)
      大塚健介
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of theradiation-induced turnover ofintestinal stem cells by Lgr5 lineagetagging system2011

    • Author(s)
      大塚健介
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of radiation-induced turnover of intestinal stem cells by Lgr5-lineage tagging system2011

    • Author(s)
      大塚 健介
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 腸管組織の幹細胞ターンオーバー2011

    • Author(s)
      大塚 健介
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      神戸商工会議所会館(兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Evaluation of the radiation-induced turnover of intestinal stem cells

    • Author(s)
      大塚 健介
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of the radiation-induced turnover of intestinal stem cells

    • Author(s)
      Kensuke Otsuka
    • Organizer
      Annual Meeting of Radiation Research Society
    • Place of Presentation
      Rio Mar Resort Hotel(アメリカ)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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