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Mechanizme analysis of accumulation of PFOS in blood

Research Project

Project/Area Number 23651053
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionKyushu University

Principal Investigator

OSHIMA Yuji  九州大学, 農学研究院, 教授 (70176874)

Co-Investigator(Kenkyū-buntansha) 島崎 洋平  九州大学, 農学研究院 (40363329)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsPFOS 結合タンパク質 / 魚類 / 血液 / PFOS / 結合タンパク質
Research Abstract

Perfluorooctane sulfonate (PFOS) was known to accumulate in blood of fish, bird and mammals. PFOS might bind with unknown substance in blood, however the mechanism is unclear. Thus, we performed to purify a PFOS binding substance from fish blood and confirmed its affinity to PFOS. As results, PFOS binding protein was successfully purified from the plasma of PFOS administered-puffer fish (Takifugu rubripes) from the 65-70% ammonium sulfate precipitation. N-terminal analysis strongly suggested that PFOS-binding protein was an apolipoprotein A-I in T. rubripes. In accorded this, PFOS was confirmed to bind with the 65-70% ammonium sulfate fraction prepared from non-PFOS treated T. rubripes. Those results indicated that PFOS was bind to apolipoprotein A-I. Thus, this may suggest disorder of physiological function because apolipoprotein A-I may play an important role in lipid metabolism in fish.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (1 results)

All 2013

All Presentation (1 results)

  • [Presentation] 魚類におけるPFOSの体内動態及び血液蓄積機構の解明2013

    • Author(s)
      牟田朱美・本田匡人・島崎洋平・大嶋雄治
    • Organizer
      日本水産学会平成25年度秋季大会
    • Place of Presentation
      三重県津市
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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