• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A method for observation of multi-cellular mechanics by fluorescent microscopy

Research Project

Project/Area Number 23651099
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nanomaterials/Nanobioscience
Research InstitutionHokkaido University

Principal Investigator

KAWABATA Kazushige  北海道大学, 大学院・先端生命科学研究院, 教授 (20261274)

Co-Investigator(Kenkyū-buntansha) MIZUTANI Takeomi  北海道大学, 大学院・先端生命科学研究院, 助教 (40451405)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsイメージング / 力学測定 / 細胞集団
Research Abstract

We tried to establish methods to measure strain within cytoskeletons or strain between cells. These methods will help us to study mechanical interaction between cytoskeletons or multi-cellular movement.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (16 results) (of which Invited: 2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Tempo-Spatial Change of Cellular Stiffness and Geometry in the Process of Developing Epithelial Cell-Cell Adhesion Measured by Atomic Force Microscopy2013

    • Author(s)
      R. Tanaka, T. Mizutani, H. Haga, K. Kawabata
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain2013

    • Author(s)
      Ishihara S, Yasuda M, Nishioka T, Mizutani T, Kawabata K, Shirato H, Haga H
    • Journal Title

      FEBS Lett

      Volume: 587(6) Issue: 6 Pages: 732-736

    • DOI

      10.1016/j.febslet.2013.01.055

    • NAID

      120005228631

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal correlates of multiple top-down signals during covert tracking of moving objects in macaque prefrontal cortex2012

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      J. Cogn. Neurosci

      Volume: 24 Issue: 01 Pages: 2043-2056

    • DOI

      10.4236/cellbio.2012.11001

    • NAID

      120005090600

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice2012

    • Author(s)
      N.Seito, et al.
    • Journal Title

      Arthritis & Rheumatism

      Volume: (印刷中) Issue: 8 Pages: 2579-88

    • DOI

      10.1002/art.34463

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷武臣
    • Journal Title

      M&M2012材料力学カンファレンス論文集

    • Related Report
      2012 Final Research Report
  • [Journal Article] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷 武臣
    • Journal Title

      M&M2012材料力学カンファレンス論文集

      Volume: M&M2012

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Active fluctuation in the cortical cytoskeleton observed by high-speed live-cell scanning probe microscopy2011

    • Author(s)
      K.Tamura, T.Mizutani, H.Haga, K.Kawabata
    • Journal Title

      Acta Biomater.

      Volume: 7 Issue: 10 Pages: 3766-3772

    • DOI

      10.1016/j.actbio.2011.06.013

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Tempo-spatial Change of Cellular Stiffness in the Process of Developing Epithelial Cell-cell Adhesion Measured by Atomic Force Microscopy2012

    • Author(s)
      R. Tanaka, T. Mizutani, H. Haga, K. Kawabata
    • Organizer
      20th International Colloquium on Scanning Probe Microscopy
    • Place of Presentation
      Okinawa Kariyushi Urban Resort Naha(那覇市)
    • Year and Date
      2012-12-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷武臣
    • Organizer
      M&M2012材料力学カンファレンス
    • Place of Presentation
      愛媛大学(松山市).
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of microtubule deformation by live cell imaging and image analysis2012

    • Author(s)
      R. Tanaka, T. Mizutani, H. Haga, K. Kawabata
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(名古屋市).
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 画像解析を用いた細胞内外の力学量計測2012

    • Author(s)
      水谷武臣
    • Organizer
      第四回「光塾」
    • Place of Presentation
      北海道大学(札幌市).
    • Year and Date
      2012-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞骨格に発生した不均一な歪み:ライブセルイメージングと画像解析による力学量測定法の提案2012

    • Author(s)
      田中良昌、水谷武臣、芳賀永、川端和重
    • Organizer
      2011年度日本生物物理学会北海道支部例会
    • Place of Presentation
      旭川市民文化会館(旭川市)
    • Year and Date
      2012-03-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of microtubule deformation by live cell imaging and image analysis2012

    • Author(s)
      Ryosuke Tanaka
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tempo-spatial Change of Cellular Stiffness in the Process of Developing Epithelial Cell-cell Adhesion2012

    • Author(s)
      Ryosuke Tanaka
    • Organizer
      20th International Colloquium on Scanning Probe Microscopy
    • Place of Presentation
      Okinawa Kariyushi Urban Resort Naha(沖縄県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 画像解析を用いた細胞内外の力学量計測2012

    • Author(s)
      水谷 武臣
    • Organizer
      第四回「光塾」
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 2次元と3次元環境下での細胞と細胞骨格の力学計測2012

    • Author(s)
      水谷 武臣
    • Organizer
      M&M2012 材料力学カンファレンス
    • Place of Presentation
      愛媛大学(松山市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生命体における巨視的構造の力学的構築2012

    • Author(s)
      川端 和重
    • Organizer
      2012年度日本冷凍空調学会年次大会
    • Place of Presentation
      北海道工業大学(札幌市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生命体におけるボトムアップ型の巨視的構造の構築2012

    • Author(s)
      川端和重
    • Organizer
      日本設計工学会(招待講演)
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞骨格に発生した不均一な歪み:ライブセルイメージングと画像解析による力学量測定法の提案2012

    • Author(s)
      田中良昌、水谷武臣、芳賀永、川端和重
    • Organizer
      2011年度日本生物物理学会北海道支部例会
    • Place of Presentation
      旭川市民文化会館(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Imaging for Cellular Mechanics: Dynamic Behavior of Cytoskeletal Networks and Cellular Contractile Force2011

    • Author(s)
      T. Mizutani
    • Organizer
      The Fifth Shanghai International Conference on Biophysics and Molecular Biology
    • Place of Presentation
      Huashia Hotel (China)
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞の時空間ダイナミクス計測:ライブセルイメージングから細胞骨格の力学バランスと細胞が発生する力をみる2011

    • Author(s)
      水谷武臣
    • Organizer
      九州大学共同利用研究会
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Cellular Mechanics: Dynamic Behavior of Cytoskeletal Networks and Cellular Contractile Force2011

    • Author(s)
      Takeomi Mizutani
    • Organizer
      The Fifth Shanghai International Conference on Biophysics and Molecular Biology(招待講演)
    • Place of Presentation
      Huashia Hotel (China)
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞の時空間ダイナミクス計測:ライブセルイメージングから細胞骨格の力学バランスと細胞が発生する力をみる2011

    • Author(s)
      水谷武臣
    • Organizer
      九州大学共同利用研究会
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2011 Research-status Report
  • [Book] 細胞のかたちと動きIV:細胞の形と細胞骨格2011

    • Author(s)
      川端和重、新宮(川端)弘子
    • Total Pages
      192
    • Publisher
      サイエンス社
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://altair.sci.hokudai.ac.jp/g3/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 細胞ダイナミクス科学研究室

    • URL

      http://altair.sci.hokudai.ac.jp/g3/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://altair.sci.hokudai.ac.jp/g3/member/kawj.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi