| Project/Area Number |
23651130
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Konan University |
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Principal Investigator |
MIYOSHI Daisuke 甲南大学, フロンティアサイエンス学部, 准教授 (50388758)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | DNAデバイス / DNA ナノテクノロジー / 金属有機構造体 / DNA / 四重らせん構造 / 金属‐有機構造体 / ナノ構造体 / DNAナノテクノロジー / G-ワイヤー / グラフェン / ビピリジン |
|---|
| Research Abstract |
To achieve practical application of bottom-up nanotechnology, designability and functionality are required. Here, we used nucleic acids as designable nanostructure scaffolds and metal complexes as functional materials. Especially, to fabricate metal complexes on DNA nanostructures, we focused on G-quadruplex, which has large aromatic planner surface. It was found that long guanine-rich DNAs fold to form a beads-on-a-string structure, making us possible to design a G-quadruplex array. Moreover, some anionic ligands such as copper phthalocyanine are suitable to bind G-quadruplex specifically. These results allow us to design nucleic acid-metal-organic nanostructure based on nucleic acid designability and metal complex functionality.
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