The accurate determination of gene loci by genome-wide approach
| Project/Area Number |
23651195
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | クロマチン / 転写 / RNA ポリメラーゼII / 発現プロファイリング / リン酸化 / RNAポリメラーゼII |
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| Research Abstract |
Cellular function is regulated by the balance of stringently regulated amounts of mRNA. Previous reports revealed that RNA polymerase II (RNAPII), which transcribes mRNA, c an be classified into the pausing state and the active transcription state according to the phosphorylation state of RPB1, the catalytic subunit of RNAPII. We examined the correlation between the phosphorylation of RNAPII and mRNA expression levels using acombined analysis by ChIPseq and RNAseq. We could visualized the recruitment of various phosphorylated RNAPIIs. Our analysis indicated that the complexity of quantitative regulation of mRNA levels could be classified into three categories according to thephosphorylation state of RNAPII.
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] Chd2 interacts with H3.3 to determine myogenic cell fate2012
Author(s)
Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y
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Journal Title
EMBO J
Volume: 31
Issue: 13
Pages: 2994-3007
DOI
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Peer Reviewed
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[Presentation] 選択的なヒストンバリアントH3.3の取り込みによる造血細胞分化運命決定機構の解明
Author(s)
小田原 淳, 植野 和子, 成相 直樹, 林 正康, 前原 一満, 原田 哲仁, 宮脇 恒太, 河野 健太郎, 島 隆宏, 吉見 智彦, 立花 太郎, 赤司 浩一, 長崎 正朗, 大川 恭行
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡国際会議場・マリンメッセ福岡（福岡）
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