Liver regeneration is dependent on sugar chain
Project/Area Number |
23651196
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Medical genome science
|
Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
GU Jianguo 東北薬科大学, 薬学部, 教授 (40260369)
|
Co-Investigator(Kenkyū-buntansha) |
FUKUDA Tomohiko 東北薬科大学, 薬学部, 准教授 (40433510)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | α1,6フコース / Fut8 / liver regeneration / 糖鎖 / 肝再生 / 増殖因子受容体 / 肝がん / 糖転移酵素 / Fut8欠損マウス / 細胞増殖 |
Research Abstract |
The expression of alpha1,6-fucosyltransferase (Fut8) and its products (alpha1,6-fucosylated N-glycans) are known to be elevated in both liver and serum during the process of hepatocarcinogenesis (HCC). However, the regulatory mechanism of high Fut8 expression in HCC progression remains poorly understood. In fact, cell proliferation plays a crucial role in the process of liver regeneration. Therefore, to examine effects of Fut8 on cell growth in vivo, we performed a partial hepatectomy on wild type and Fut8 knockout mice to induce liver regeneration. Interestingly, the speed of liver regeneration in Fut8 knockout mice was significantly slower than that in wild-type mice. Interestingly, an oral administration of L-fucose significantly accelerated liver regeneration of the Fut8-hetero mice, but did not affect the sham mice. These results further suggest that Fut8 and its products are important for cell proliferation in liver regeneration.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] α1, 6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells : the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling2013
Author(s)
Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J
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Journal Title
FASEB J
Volume: 27
Pages: 3947-3958
Related Report
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[Journal Article] α1,6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells: the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling.2013
Author(s)
Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J.
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Journal Title
FASEB J
Volume: 27
Issue: 10
Pages: 3947-3958
DOI
Related Report
Peer Reviewed
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[Journal Article] Core fucosylation of mu heavy chains regulates the assembly of precursor B cell receptors and its intracellular signaling2012
Author(s)
Li, W., Liu, Q., Pang, Y., Jin, J., Wang, H., Cao, H., Li, Z., Wang, X., Ma, B., Chi, Y., Wang, R., Kondo, A., Gu, J. and Taniguchi, N
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Journal Title
J Biol Chem
Volume: 287
Pages: 2500-2508
Related Report
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