A study of thermodynamics and Information processing in the transcription factory
| Project/Area Number |
23651201
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IHARA Sigeo 東京大学, 先端科学技術研究センター, 特任教授 (30345136)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Yoshihiro 東京大学, 先端科学技術研究センター, 特任助教 (80436592)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | モデル化 / シミュレーション / 転写過程 / 散逸構造 / ゲノム科学 |
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| Research Abstract |
RNA polymerase II (RNAPII) molecule is responsible for transcription that is a central cellular process. To reveal the principles of transcription, we have derived a mathematical model for RNAPII from the high-resolution molecular biological data. Cellular automaton simulations show that the cooperative motions of RNAPII molecules that represented by the injection timing of TSS, the barriers of the roadblocks due to the chromatin modifications that represented by the velocity gap, and the chromatin loop positions represented by the jump probabilities of RNAPII affect the dynamical and thermo-dynamical properties of transcription factory.
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Report
(3 results)
Research Products
(19 results)
