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Synthetic approaches to investigate artificial living systems by RNA self-replicating ribozymes

Research Project

Project/Area Number 23651203
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field System genome science
Research InstitutionKyoto University

Principal Investigator

SAITO Hirohide  京都大学, 白眉センター, 准教授 (20423014)

Co-Investigator(Kenkyū-buntansha) NOMURA Shin-ichiro  東北大学, 工学(系)研究科(研究員院), 准教授 (50372446)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsRNA / 人工細胞モデル / 生命の起源 / 合成生物学 / 人工細胞 / RNP / バイオエンジニアリング / リポソーム / 実験進化
Research Abstract

One of the main goals in science is to solve the problem of origin of life: How evolvable living systems have emerged from chemical molecules such as nucleic acids? RNA can function both as an informational molecule and as a catalyst in living organisms. This duality is the premise of the RNA world hypothesis in the origin of life theory. Specially, it is believed that RNA ribozyme that facilitates self-replicating reaction is one of the most essential molecules in primitive life. To verify whether RNA has the potential for self-replication, we constructed a new RNA self-assembling ribozyme that could have conducted an evolvable RNA self-replication reaction. The artificially designed, in vitro selected ligase ribozyme was employed as a prototype for a self-assembling ribozyme. We propose that our system implies the significance of RNA tertiary motifs in the early RNA molecular evolution of the RNA world. Furthermore, we designed the synthetic RNA sequence for making higher-order membrane like structure. Giant membrane structure might be observed by using fluorescence microscopy. Their forming condition should be investigated and the result should be reported as a research article. These results may provide a possible RNA world in which both replicator and the compartment could be made by RNA. This concept might provide an alternative way to investigate the problem of the origin of life.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (67 results)

All 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (48 results) (of which Invited: 6 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Condensation of an Additive-Free Cell Extract to Mimic the Conditions of Live Cells2013

    • Author(s)
      Kei Fujiwara, Shin-ichiro M. Nomura
    • Journal Title

      PLoS ONE

      Volume: 8(1)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Directed evolution ot a syntnetic RNA-protein module to create a new translational switch2013

    • Author(s)
      原知明、齊藤博英、井上丹
    • Journal Title

      Chemical Communications

      Volume: 49 Issue: 37 Pages: 3833-3835

    • DOI

      10.1039/c3cc38688k

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生命システムの理解と制御を目指す合成生物学-その現状と課題-2012

    • Author(s)
      齊藤 博英
    • Journal Title

      生物学史研究  2012年2月号

      Volume: 86 Pages: 45-56

    • Related Report
      2011 Research-status Report
  • [Journal Article] Self-Replication Reactions Dependent on Tertiary Interaction Motifs in an RNA Ligase Ribozyme2011

    • Author(s)
      Rei Ohmori, Hirohide Saito, Yochiya Ikawa,YoshihikoFujita,Tan Inoue
    • Journal Title

      J Mol Evol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and in situ insertion of a site-specific fluorescently labeled membrane protein into cell-sized liposomes2011

    • Author(s)
      Takuma Ohtsuka, Satoshi Neki, Tamotsu Kanai, Kazunari Akiyoshi, Shin-ichiro M. Nomura, Takashi Ohtsuki
    • Journal Title

      Analytical Biochemistry

      Volume: 418 Pages: 97-101

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthetic human cell fate regulation by protein-driven RNA swiches2011

    • Author(s)
      *Hirohide Saito, Yoshihiko Fujita, Shunnichi Kashida, Karin Hayashi, and Tan Inoue
    • Journal Title

      Nature Communications

      Volume: 2 Issue: 1 Pages: 160-160

    • DOI

      10.1038/ncomms1157

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthetic RNA-protein complex shaped like an equilateral triangle2011

    • Author(s)
      Hirohisa Ohno, Tetsuhiro Kobayashi, Rinko Kabata, Kei Endo, Takuma Iwasa, Shige Yoshimura, Kunio Takeyasu, Tan Inoue, and *Hirohide Saito
    • Journal Title

      Nature Nanotechnology

      Volume: 6 Issue: 2 Pages: 116-120

    • DOI

      10.1038/nnano.2010.268

    • NAID

      120005600989

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-Replication Reactions Dependent on Tertiary Interaction Motifs in an RNA Ligase Ribozyme2011

    • Author(s)
      Rei Ohmori, Hirohide Saito, Yochiya Ikawa,Yoshihiko Fujita,Tan Inoue
    • Journal Title

      Journal of Molecular Evolution

      Volume: 73 Issue: 3-4 Pages: 221-229

    • DOI

      10.1007/s00239-011-9471-2

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Light-Regulated mRNA Condensation by a Photosensitive Surfactant Works as a Series Photoswitch of Translation Activity in the Presence of Small RNAs2011

    • Author(s)
      Sergii Rudiuk, Hirohide Saito, Tomoaki Hara, Tan Inoue, Kenichi Yoshikawa, Damein Baigl
    • Journal Title

      Biomacromolecules

      Volume: 12 Issue: 11 Pages: 3945-3951

    • DOI

      10.1021/bm200962s

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 翻訳をON/OFFする人工RNAスイッチ―シンセティック・バイオロジーの新技術2011

    • Author(s)
      齊藤 博英、井上 丹
    • Journal Title

      化学 2011年5月号 (Vo.66 No5)

      Volume: 66 Pages: 46-50

    • NAID

      40018802656

    • Related Report
      2011 Research-status Report
  • [Journal Article] Three-dimensionally designed protein-responsive RNA devices for cell signaling regulation

    • Author(s)
      Shunnichi Kashida, *Tan Inoue, and *Hirohide Saito
    • Journal Title

      Nucleic Acids Research

      Volume: 40(18) Pages: 9369-9378

    • NAID

      120004920410

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Feedback Control of Protein Expression in Mammalian Cells by Tunable Synthetic Translational Inhibition

    • Author(s)
      James A. Stapleton, Kei Endo, Yoshihiko Fujita, Karin Hayashi, Masahiro Takinoue, *Hirohide Saito, and Tan Inoue
    • Journal Title

      ACS Synthetic Biology

      Volume: 1(3) Pages: 83-88

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthetic human cell fate regulation by protein-driven RNA swiches

    • Author(s)
      Hirohide Saito, Yoshihiko Fujita, Shunnichi Kashida, Karin Hayashi, and *Tan Inoue
    • Journal Title

      Nature Communications

      Volume: 2 Pages: 160-160

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic RNA-protein complex shaped like an equilateral triangle

    • Author(s)
      Hirohisa Ohno, Tetsuhiro Kobayashi, Rinko Kabata, Kei Endo, Takuma Iwasa, Shige Yoshimura, Kunio Takeyasu, *Tan Inoue, and *Hirohide Saito
    • Journal Title

      Nature Nanotechnology

      Volume: 6(2) Pages: 116-120

    • NAID

      120005600989

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Molecular robotics for artificial cell-model construction2013

    • Author(s)
      Shin-ichiro M. NOMURA, Yusuke SATO, Kei FUJIWARA, Shogo HAMADA, SatoshiMURATA
    • Organizer
      AROB18(18th Int. Sympo. on Artificial Life and Robotics)
    • Place of Presentation
      韓国 Daejeon
    • Year and Date
      2013-01-30
    • Related Report
      2012 Final Research Report
  • [Presentation] RNA-たんぱく質複合体を用いたナノバイオエンジニアリング2013

    • Author(s)
      齊藤 博英
    • Organizer
      精密工学会 超精密加工専門委員会 第65回研究会
    • Place of Presentation
      大阪
    • Year and Date
      2013-01-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Synthetic RNA-protein complexes to control mammalian cell fate2013

    • Author(s)
      Hirohide Saito
    • Organizer
      Winter q-bio international meeting Oafu
    • Place of Presentation
      Hilton Hawaiian Village in Waikiki (Hawaii,U.S.A)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "超分子マイクロクローラの構築"2013

    • Author(s)
      小松 大貴,藤原 慶,浜田 省吾,村田 智,野村 M. 慎一郎
    • Organizer
      自律分散システム研究会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "Adsorption of DNA ring onto Liposome"2012

    • Author(s)
      Yumiko Kumagai, Shogo Hamada, Shin-ichiro M. Nomura, Satoshi Murata
    • Organizer
      生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "Artificial Panspermia by molecular robotics"2012

    • Author(s)
      M. Endo, K. Fujiwara, S. Hamada, S. Murata, Shin-ichiro. M. Nomura
    • Organizer
      生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "Construction of a remote control molecule crawler prototype"2012

    • Author(s)
      Daiki Komatsu, Kei Fujiwara, Shin-ichiro M. Nomura
    • Organizer
      生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "Prototype molecular robots working on cellular membrane"2012

    • Author(s)
      Yusuke Sato, K. Fuziwara, S. Hamada, S. Murata, Shin-ichiro. M. Nomura
    • Organizer
      生物物理学会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "細胞膜上で動作するプロトタイプ分子ロボット"2012

    • Author(s)
      佐藤 佑介, 藤原 慶, 浜田 省吾, 村田 智, 野村 M. 慎一郎
    • Organizer
      細胞をつくる研究会5.0
    • Place of Presentation
      東京工業大学すずかけ台キャンパス(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 人工RNAを用いる新しい遺伝子操作技術2012

    • Author(s)
      齊藤 博英
    • Organizer
      ヒト多機能性幹細胞の培養・解析の標準化レクチャーシリーズ第6回(招待講演)
    • Place of Presentation
      独立行政法人理化学研究所 神戸研究所 発生・再生科学総合研究センター(神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 人工RNAスイッチ・ナノ構造体を活用した細胞運命制御システムの構築とイメージングへの可能性 "Synthetic RNA switches and nanostructure for controlling sell function"2012

    • Author(s)
      齊藤 博英
    • Organizer
      Center for Molecular Imaging Science Seminar(招待講演)
    • Place of Presentation
      独立行政法人理化学研究所 神戸研究所 分子イメージング科学研究センター(神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] iPSとYAC: 両末端から生命-likeシステムの構築に迫る方法はあるか?2012

    • Author(s)
      齊藤 博英
    • Organizer
      2011年度"Yet Another Artificial-Cells"研究会
    • Place of Presentation
      東京工業大学(横浜市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 超純水と超音波による簡便なcell-free翻訳溶液調製2012

    • Author(s)
      藤原 慶、野村 M. 慎一郎
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 分子ロボティクスにおける RNA-タンパク質 複合体の可能性2011

    • Author(s)
      齊藤博英、大野博久、井上丹
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 人工RNA-タンパク質ナノ構造体を活用したバイオエンジニアリング2011

    • Author(s)
      齊藤 博英
    • Organizer
      第8回分子複合医薬研究会(招待講演)
    • Place of Presentation
      産業技術総合研究所 関西センター(大阪府池田市)
    • Related Report
      2011 Research-status Report
  • [Presentation] RNAシンセティックバイオロジーとアストロバイオロジーの接点2011

    • Author(s)
      齊藤 博英
    • Organizer
      第4回アストロバイオロジーワークショップ(招待講演)
    • Place of Presentation
      神戸大学(神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 人工RNA-タンパク質複合型ナノシステムによる細胞機能制御2011

    • Author(s)
      齊藤 博英
    • Organizer
      第17回創剤フォーラム若手研究会 核酸工学・核酸医薬の新展開(招待講演)
    • Place of Presentation
      京都大学(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 人工RNAとiPS細胞を用いた精密な細胞運命制御にむけて2011

    • Author(s)
      齊藤 博英
    • Organizer
      CiRA MINI-SYMPOSIUM 2011
    • Place of Presentation
      京都大学(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mammalian mRNA engineering for controlling transgene expression in response to an intracellular protein2011

    • Author(s)
      Kei Endo,Tan Inoue,and Hirohide Saito
    • Organizer
      「細胞を創る」研究会4.0
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] RNA/RNP molecular design and functional RNP nanostructure for controlling cell function2011

    • Author(s)
      Eriko Osada,Yoshihiko Fujita,Rie Furushima,Hirohisa Ohno,Tan Inoue, and Hirohide Saito
    • Organizer
      「細胞を創る」研究会4.0
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthetic RNA/RNP biology-based approaches to regulate cellular functions2011

    • Author(s)
      Hirohide Saito,Yoshihiko Fujita,Kei Endo,Hirohisa Ohno,Shunnichi Kashida,Eriko Osada, and Tan Inoue
    • Organizer
      「細胞を創る」研究会4.0(招待講演)
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Design and synthesis of RNA/RNP-based molecules and systems2011

    • Author(s)
      齊藤 博英
    • Organizer
      ERATO International Symposium on Synthesizing life and biological systems(招待講演)
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 人工RNAスイッチ・ナノ構造体を基盤とする細胞操作・運命制御システムの開発2011

    • Author(s)
      齊藤 博英
    • Organizer
      第5回物質科学フロンティアセミナー「新時代の物質創製を目指して -光、金属、生命を操る-」(招待講演)
    • Place of Presentation
      名古屋大学(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 生命の起源と宇宙の接点~生命は宇宙から降ってきた?2011

    • Author(s)
      大野 博久、齊藤 博英
    • Organizer
      第7回お寺で宇宙学(招待講演)
    • Place of Presentation
      浄慶寺(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] RNPシンセティック・バイオロジー2011

    • Author(s)
      齊藤 博英、藤田 祥彦、樫田 俊一、大野 博久、遠藤 慧、井上 丹
    • Organizer
      第63回日本生物工学会大会
    • Place of Presentation
      東京農工大学(東京都小金井市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 分子デザイン型人工RNA-タンパク質複合体を活用した細胞機能制御技術の開発2011

    • Author(s)
      長田 江里子、齊藤 博英
    • Organizer
      第10回産学官連携推進会議
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 分子ロボティクスにおけるRNA-タンパク質複合体の可能性2011

    • Author(s)
      齊藤 博英、大野 博久、井上 丹
    • Organizer
      第84回日本生化学会大会(招待講演)
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 人工RNAスイッチを活用した細胞機能・運命制御2011

    • Author(s)
      齊藤 博英
    • Organizer
      遺伝子・デリバリー研究会 第11回夏期セミナー(招待講演)
    • Place of Presentation
      三翠園ホテル(高知県高知市)
    • Related Report
      2011 Research-status Report
  • [Presentation] RNA-Protein複合体の分子デザインが拓く新世界2011

    • Author(s)
      齊藤 博英
    • Organizer
      ERATO伊藤グライコトリロジープロジェクトシンポジウム(招待講演)
    • Place of Presentation
      独立行政法人理化学研究所 和光研究所(埼玉県和光市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 冷静と情熱のあいだ:RNAシンセティックバイオロジーの現状と未来2011

    • Author(s)
      齊藤 博英
    • Organizer
      生化学若い研究者の会 初夏セミナー(招待講演)
    • Place of Presentation
      奈良女子大学(奈良県奈良市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthetic approaches to construct RNA protein complexes-based nanostructures and translational regulatory system2011

    • Author(s)
      齊藤 博英、大野 博久、樫田 俊一、遠藤 慧、James A Stapleton、藤田 祥彦、井上 丹
    • Organizer
      第16回RNA Society Meeting(招待講演)
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 超純水と超音波で調製した無細胞タンパク質合成系2011

    • Author(s)
      藤原 慶、野村 M. 慎一郎
    • Organizer
      無細胞生命科学研究会
    • Place of Presentation
      兵庫県立大学(兵庫県姫路市)
    • Related Report
      2011 Research-status Report
  • [Presentation] An ion-sensing device consists of genetically-tuned bacteria.2011

    • Author(s)
      Kei FUJIWARA, Keita AOI, Shin-ichiro M. NOMURA
    • Organizer
      International Symposium on SYNTHESIZING LIFE AND BIOLOGICAL SYSTEMS(細胞を創る研究会4.0合同開催)
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Cloud liposomes squeezed up from multi-linked pore structures.2011

    • Author(s)
      Shin-ichiro M. NOMURA, Kei FUJIWARA, Keita AOI
    • Organizer
      International Symposium on SYNTHESIZING LIFE AND BIOLOGICAL SYSTEMS(細胞を創る研究会4.0合同開催)
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2011 Research-status Report
  • [Presentation] A bacterial ion-sensing device without electrodes.2011

    • Author(s)
      Fujiwara Kei, Aoi Keita, Nomura M. Shin-ichiro
    • Organizer
      第49回日本生物物理学会年会
    • Place of Presentation
      兵庫県立大学(兵庫県姫路市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 細胞サイズリポソームは超分子ロボット構築に有効なデバイスであるか2011

    • Author(s)
      野村 M. 慎一郎、藤原慶、青井啓太
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthetic RNA-protein technologies for controlling translation in mammalian cells

    • Author(s)
      齊藤 博英
    • Organizer
      第12回日本蛋白質科学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 人工RNAシステムを活用した遺伝子操作・細胞運命制御技術体系の創出

    • Author(s)
      齊藤 博英、遠藤 慧
    • Organizer
      第14回日本RNA学会年会
    • Place of Presentation
      東北大学百周年記念会館 川内萩ホール(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子ロボティクスにおける感覚機能の実装にむけて

    • Author(s)
      齊藤 博英
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞内シグナル回路をデザインするRNAテクノロジー

    • Author(s)
      齊藤 博英
    • Organizer
      第5回北陸合同バイオ若手シンポジウム
    • Place of Presentation
      福井県民ホール(福井県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 人工RNAスイッチによる自律的な細胞運命制御システムの構築に向けて

    • Author(s)
      齊藤 博英
    • Organizer
      定量生物学の会 第5回年会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Synthetic RNA-Protein Complexes for Controlling Cell Signaling

    • Author(s)
      齊藤 博英
    • Organizer
      生体機能関連部会国際シンポジウム
    • Place of Presentation
      東京工業大学蔵前会館(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 〔第10回日本分子生物学会三菱化学奨励賞受賞講演〕機能性RNAの分子デザインによる翻訳・細胞運命制御システム構築の研究Translational regulation and cell fate control by constructing functional RNA molecules

    • Author(s)
      齊藤 博英
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] RNA-たんぱく質複合体を用いたナノバイオエンジニアリング

    • Author(s)
      齊藤 博英
    • Organizer
      精密工学会 超精密加工専門委員会 第65回研究会
    • Place of Presentation
      メルパルク大阪(大阪府)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Artificial Cell-models consist of Giant Liposome equipping Membrane Proteins

    • Author(s)
      Shin-ichiro M. Nomura
    • Organizer
      German-Japanese International Workshop “Structure and Control of Interfaces”
    • Place of Presentation
      Magnus-Haus Berlin(Berlin,Germany )
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular robotics for artificial cell-model construction

    • Author(s)
      Shin-ichiro M. NOMURA, Yusuke SATO, Kei FUJIWARA, Shogo HAMADA, Satoshi MURATA
    • Organizer
      AROB18(18th Int. Sympo. on Artificial Life and Robotics) Daejeon
    • Place of Presentation
      Daejeon Convention Center(Daejeon, KOREA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "人工細胞研究における分子ロボティクスアプローチ"

    • Author(s)
      野村 M. 慎一郎,藤原 慶
    • Organizer
      農芸化学会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] "細胞に近い高分子濃度を持つ無添加細胞抽出液の調製"

    • Author(s)
      藤原 慶, 柳澤 美穂, 野村 M. 慎一郎
    • Organizer
      農芸化学会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Book] 人工細胞モデルとコミュニケーション能(細胞を創る・生命システムを創る)2011

    • Author(s)
      野村M. 慎一郎 (竹内昌治、上田泰己・編)
    • Total Pages
      220
    • Publisher
      羊土社
    • Related Report
      2011 Research-status Report
  • [Book] Synthetic RNA-Protein Nanostructures and Their Potential Applications Review: RNA Nanotechnology and Therapeutics

    • Author(s)
      ed. Guo, P.
    • Publisher
      CRC press(in press)
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.cira.kyoto-u.ac.jp/saito/

    • Related Report
      2012 Final Research Report
  • [Remarks] 京都大学 iPS細胞研究所 齊藤博英研究室

    • URL

      http://www.cira.kyoto-u.ac.jp/saito/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] RNA-蛋白質相互作用モチーフを利用した蛋白質翻訳量調整システム2012

    • Inventor(s)
      齊藤博英、遠藤 慧、井上 丹
    • Industrial Property Rights Holder
      齊藤博英、遠藤 慧、井上 丹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-16
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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