Rational design of synthetic signaling activators by subcellular targeting of protein ligands
| Project/Area Number |
23651214
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagaoka University of Technology |
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Principal Investigator |
TSUKIJI Shinya 長岡技術科学大学, 産学融合トップランナー養成センター, 特任准教授 (40359659)
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|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生物活性分子の設計 / 合成 / シグナル伝達 / アゴニスト / 合成リガンド / 細胞内局在 / キナーゼ / 脂質 / 細胞運動 |
|---|
| Research Abstract |
In this work, we have designed and created synthetic self-localizing ligands that spontaneously localize to specific organelles or membrane regions in living cells. Using the ligands and protein engineering, we have developed a new cell control method that allows conditional induction of protein translocation and cell signaling in mammalian cells.
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Report
(3 results)
Research Products
(26 results)
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[Book] 未来材料2013
Author(s)
築地真也, 浜地格
Publisher
局在性リガンドによ る細胞内情報伝達誘導システム
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