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Supramolecular Assembly of Amphiphilic Mesogenic Compounds InducingApoptosis in a Human Solid Cancer Cell Line

Research Project

Project/Area Number 23651229
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Chemical biology
Research InstitutionHirosaki University

Principal Investigator

YOSHIZAWA Atsushi  弘前大学, 大学院・理工学研究科, 教授 (30322928)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords医薬品探索 / 液晶 / 分子認識 / がん / アポトーシス / 抗腫瘍効果 / 肺がん / 細胞死 / 癌 / 超分子化学
Research Abstract

We investigated anti-cancer activity of mesogenic compounds possessing a hydroxyl group. The compounds were tested against A549 human lung adenocarcinoma cell line. Three ring heterocyclic derivatives containing a phenol unit showed significant suppression of the cell growth. The cell cycle analysis indicates that these compounds induce apoptosis. To determine the influence of these derivatives on normal cells, they were tested against WI-38 human lung fibroblast cell line under the same condition. Very interestingly, suppression of the normal cells was found to be dependent on the core structure of the mesogenic moiety. Some compounds induces apoptosis selectively against the tumor cell without suppressing the normal cell.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (9 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Liquid crystal-related compound induces cell cycle arrest at G2/M phase and apoptosis in human non-small cancer cell line A5492013

    • Author(s)
      Takuya Wakasaya
    • Journal Title

      International Journal of Oncology

      Volume: 42 Issue: 4 Pages: 1205-1211

    • DOI

      10.3892/ijo.2013.1804

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 創薬化学における液晶2013

    • Author(s)
      福士由佳子,吉澤篤
    • Journal Title

      液晶

      Volume: 16 Pages: 21-29

    • NAID

      10030212423

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive effects of liquid crystal compounds on the growth of U937 human leukemic monocyte lymphoma cells2012

    • Author(s)
      I.Kashiwakura, et al.
    • Journal Title

      Cancer Cell Int

      Volume: 12 Issue: 1 Pages: 1-7

    • DOI

      10.1186/1475-2867-12-3

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 創薬化学における液晶2012

    • Author(s)
      福士由佳子、吉澤 篤
    • Journal Title

      液晶

      Volume: 16 Pages: 21-29

    • NAID

      10030212423

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 液晶性化合物によるヒト肺がん細胞株A549の増殖抑制効果と構造-活性相関2013

    • Author(s)
      福士紗織
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 液晶性化合物のがん増殖抑制におけるクラウンエーテルの効果2013

    • Author(s)
      田中里奈
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 液晶性化合物によるヒト肺がん細胞株A549の増殖抑制効果と構造-活性相関2013

    • Author(s)
      福士紗織
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜 横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 液晶性化合物のがん増殖抑制におけるクラウンエーテルの効果2013

    • Author(s)
      田中里奈
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜 横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 液晶性化合物によるA549ヒト肺がん細胞へのアポトーシス誘導2012

    • Author(s)
      福士紗織
    • Organizer
      2012年日本液晶学会討論会
    • Place of Presentation
      千葉大学西千葉キャンパス(千葉市)
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト肺癌細胞株に対するクラウンエーテル含有液晶性化合物の抗腫瘍効果2012

    • Author(s)
      田中里奈
    • Place of Presentation
      千葉大学西千葉キャンパス(千葉市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 液晶性化合物による A549 ヒト肺がん細胞へのアポトーシス誘導2012

    • Author(s)
      福士紗織
    • Organizer
      2012年日本液晶学会討論会
    • Place of Presentation
      千葉大学西千葉キャンパス 千葉市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト肺癌細胞株に対するクラウンエーテル含有液晶性化合物の抗腫瘍効果2012

    • Author(s)
      田中里奈
    • Organizer
      2012年日本液晶学会討論会
    • Place of Presentation
      千葉大学西千葉キャンパス 千葉市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 末端ヒドロキシ基を持つ液晶性化合物の相転移挙動と薬理活性作用2011

    • Author(s)
      福士由佳子、吉野浩教、石川純也、鷺坂将伸、柏倉幾郎、吉澤 篤
    • Organizer
      2011年日本液晶学会討論会
    • Place of Presentation
      東京都市大学世田谷キャンパス
    • Related Report
      2011 Research-status Report
  • [Book] 液晶の創薬分野への展開2013

    • Author(s)
      吉澤篤
    • Publisher
      エース出版
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.st.hirosaki-u.ac.jp/~lclab/

    • Related Report
      2012 Final Research Report
  • [Remarks] 吉澤鷺坂研究室ホームページ

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.st.hirosaki-u.ac.jp/~lclab/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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