| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In order to further sophisticate biotin-streptavidin system that is used as a universal binding pair in chemical biology, we screened a large library of approximately 160,000 compounds for novel ligands to streptavidin. As a result, we succeeded in obtaining new ligands that have affinities to the protein in the order of 1 μM. Moreover, we analyzed their binding mechanisms in detail by X-ray crystallography and computer simulation.
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